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Fluorine in PDB 6mvo: Hcv NS5B 1A Y316 Bound to Compound 49Enzymatic activity of Hcv NS5B 1A Y316 Bound to Compound 49
All present enzymatic activity of Hcv NS5B 1A Y316 Bound to Compound 49:
2.7.7.48; Protein crystallography data
The structure of Hcv NS5B 1A Y316 Bound to Compound 49, PDB code: 6mvo
was solved by
S.P.Williams,
K.Kahler,
D.J.Price,
A.J.Peat,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 6mvo:
The structure of Hcv NS5B 1A Y316 Bound to Compound 49 also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Hcv NS5B 1A Y316 Bound to Compound 49
(pdb code 6mvo). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Hcv NS5B 1A Y316 Bound to Compound 49, PDB code: 6mvo: Jump to Fluorine binding site number: 1; 2; Fluorine binding site 1 out of 2 in 6mvoGo back to Fluorine Binding Sites List in 6mvo
Fluorine binding site 1 out
of 2 in the Hcv NS5B 1A Y316 Bound to Compound 49
Mono view Stereo pair view
Fluorine binding site 2 out of 2 in 6mvoGo back to Fluorine Binding Sites List in 6mvo
Fluorine binding site 2 out
of 2 in the Hcv NS5B 1A Y316 Bound to Compound 49
Mono view Stereo pair view
Reference:
P.Y.Chong,
J.B.Shotwell,
J.Miller,
D.J.Price,
A.Maynard,
C.Voitenleitner,
A.Mathis,
S.Williams,
J.J.Pouliot,
K.Creech,
F.Wang,
J.Fang,
H.Zhang,
V.W.Tai,
E.Turner,
K.M.Kahler,
R.Crosby,
A.J.Peat.
Design of N-Benzoxaborole Benzofuran GSK8175-Optimization of Human Pharmacokinetics Inspired By Metabolites of A Failed Clinical Hcv Inhibitor. J.Med.Chem. V. 62 3254 2019.
Page generated: Sun Dec 13 12:59:04 2020
ISSN: ISSN 0022-2623 PubMed: 30763090 DOI: 10.1021/ACS.JMEDCHEM.8B01719 |
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