Fluorine in PDB 6n3l: Identification of Novel, Potent and Selective GCN2 Inhibitors As First-in-Class Anti-Tumor Agents
Enzymatic activity of Identification of Novel, Potent and Selective GCN2 Inhibitors As First-in-Class Anti-Tumor Agents
All present enzymatic activity of Identification of Novel, Potent and Selective GCN2 Inhibitors As First-in-Class Anti-Tumor Agents:
2.7.11.1;
2.7.11.1;
Protein crystallography data
The structure of Identification of Novel, Potent and Selective GCN2 Inhibitors As First-in-Class Anti-Tumor Agents, PDB code: 6n3l
was solved by
I.D.Hoffman,
J.Fujimoto,
O.Kurasawa,
T.Takagi,
M.G.Klein,
G.Kefala,
S.C.Ding,
D.R.Cary,
R.Mizojiri,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 25.00 / 2.61 |
| Space group | C 2 2 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 83.886, 122.233, 120.674, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 22.3 / 29 |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Identification of Novel, Potent and Selective GCN2 Inhibitors As First-in-Class Anti-Tumor Agents
(pdb code 6n3l). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 6 binding sites of Fluorine where determined in the Identification of Novel, Potent and Selective GCN2 Inhibitors As First-in-Class Anti-Tumor Agents, PDB code: 6n3l:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6;
In total 6 binding sites of Fluorine where determined in the Identification of Novel, Potent and Selective GCN2 Inhibitors As First-in-Class Anti-Tumor Agents, PDB code: 6n3l:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6;
Fluorine binding site 1 out of 6 in 6n3l
Go back to
Fluorine Binding Sites List in 6n3l
Fluorine binding site 1 out
of 6 in the Identification of Novel, Potent and Selective GCN2 Inhibitors As First-in-Class Anti-Tumor Agents
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Identification of Novel, Potent and Selective GCN2 Inhibitors As First-in-Class Anti-Tumor Agents within 5.0Å range:
|
Fluorine binding site 2 out of 6 in 6n3l
Go back to
Fluorine Binding Sites List in 6n3l
Fluorine binding site 2 out
of 6 in the Identification of Novel, Potent and Selective GCN2 Inhibitors As First-in-Class Anti-Tumor Agents
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Identification of Novel, Potent and Selective GCN2 Inhibitors As First-in-Class Anti-Tumor Agents within 5.0Å range:
|
Fluorine binding site 3 out of 6 in 6n3l
Go back to
Fluorine Binding Sites List in 6n3l
Fluorine binding site 3 out
of 6 in the Identification of Novel, Potent and Selective GCN2 Inhibitors As First-in-Class Anti-Tumor Agents
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Identification of Novel, Potent and Selective GCN2 Inhibitors As First-in-Class Anti-Tumor Agents within 5.0Å range:
|
Fluorine binding site 4 out of 6 in 6n3l
Go back to
Fluorine Binding Sites List in 6n3l
Fluorine binding site 4 out
of 6 in the Identification of Novel, Potent and Selective GCN2 Inhibitors As First-in-Class Anti-Tumor Agents
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 4 of Identification of Novel, Potent and Selective GCN2 Inhibitors As First-in-Class Anti-Tumor Agents within 5.0Å range:
|
Fluorine binding site 5 out of 6 in 6n3l
Go back to
Fluorine Binding Sites List in 6n3l
Fluorine binding site 5 out
of 6 in the Identification of Novel, Potent and Selective GCN2 Inhibitors As First-in-Class Anti-Tumor Agents
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 5 of Identification of Novel, Potent and Selective GCN2 Inhibitors As First-in-Class Anti-Tumor Agents within 5.0Å range:
|
Fluorine binding site 6 out of 6 in 6n3l
Go back to
Fluorine Binding Sites List in 6n3l
Fluorine binding site 6 out
of 6 in the Identification of Novel, Potent and Selective GCN2 Inhibitors As First-in-Class Anti-Tumor Agents
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 6 of Identification of Novel, Potent and Selective GCN2 Inhibitors As First-in-Class Anti-Tumor Agents within 5.0Å range:
|
Reference:
J.Fujimoto,
O.Kurasawa,
T.Takagi,
X.Liu,
H.Banno,
T.Kojima,
Y.Asano,
A.Nakamura,
T.Nambu,
A.Hata,
T.Ishii,
T.Sameshima,
Y.Debori,
M.Miyamoto,
M.G.Klein,
R.Tjhen,
B.C.Sang,
I.Levin,
S.W.Lane,
G.P.Snell,
K.Li,
G.Kefala,
I.D.Hoffman,
S.C.Ding,
D.R.Cary,
R.Mizojiri.
Identification of Novel, Potent, and Orally Available GCN2 Inhibitors with Type I Half Binding Mode. Acs Med.Chem.Lett. V. 10 1498 2019.
ISSN: ISSN 1948-5875
PubMed: 31620240
DOI: 10.1021/ACSMEDCHEMLETT.9B00400
Page generated: Sun Dec 13 12:59:25 2020
ISSN: ISSN 1948-5875
PubMed: 31620240
DOI: 10.1021/ACSMEDCHEMLETT.9B00400
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