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Fluorine in PDB 6nky: Ternary Complex Crystal Structure of K289M Variant of Dna Polymerase Beta with "Hot-Spot Sequence" with Beta-Gamma Chf Analogue of Dgtp

Enzymatic activity of Ternary Complex Crystal Structure of K289M Variant of Dna Polymerase Beta with "Hot-Spot Sequence" with Beta-Gamma Chf Analogue of Dgtp

All present enzymatic activity of Ternary Complex Crystal Structure of K289M Variant of Dna Polymerase Beta with "Hot-Spot Sequence" with Beta-Gamma Chf Analogue of Dgtp:
2.7.7.7;

Protein crystallography data

The structure of Ternary Complex Crystal Structure of K289M Variant of Dna Polymerase Beta with "Hot-Spot Sequence" with Beta-Gamma Chf Analogue of Dgtp, PDB code: 6nky was solved by V.K.Batra, S.H.Wilson, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 21.98 / 2.09
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 50.643, 80.158, 55.251, 90.00, 107.89, 90.00
R / Rfree (%) 19.9 / 25.6

Other elements in 6nky:

The structure of Ternary Complex Crystal Structure of K289M Variant of Dna Polymerase Beta with "Hot-Spot Sequence" with Beta-Gamma Chf Analogue of Dgtp also contains other interesting chemical elements:

Magnesium (Mg) 1 atom
Chlorine (Cl) 3 atoms
Sodium (Na) 3 atoms

Fluorine Binding Sites:

The binding sites of Fluorine atom in the Ternary Complex Crystal Structure of K289M Variant of Dna Polymerase Beta with "Hot-Spot Sequence" with Beta-Gamma Chf Analogue of Dgtp (pdb code 6nky). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Ternary Complex Crystal Structure of K289M Variant of Dna Polymerase Beta with "Hot-Spot Sequence" with Beta-Gamma Chf Analogue of Dgtp, PDB code: 6nky:

Fluorine binding site 1 out of 1 in 6nky

Go back to Fluorine Binding Sites List in 6nky
Fluorine binding site 1 out of 1 in the Ternary Complex Crystal Structure of K289M Variant of Dna Polymerase Beta with "Hot-Spot Sequence" with Beta-Gamma Chf Analogue of Dgtp


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Ternary Complex Crystal Structure of K289M Variant of Dna Polymerase Beta with "Hot-Spot Sequence" with Beta-Gamma Chf Analogue of Dgtp within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F408

b:37.2
occ:1.00
 F3B A:GFH408 0.0 37.2 1.0
C3B A:GFH408 1.3 31.9 1.0
PB A:GFH408 2.6 28.2 1.0
PG A:GFH408 2.6 33.7 1.0
O1B A:GFH408 2.8 30.6 1.0
O3G A:GFH408 2.8 29.3 1.0
NH2 A:ARG183 3.1 31.7 1.0
O A:HOH552 3.2 46.1 1.0
O A:HOH656 3.3 43.7 1.0
CB A:SER180 3.5 30.9 1.0
O2B A:GFH408 3.5 24.3 1.0
O2G A:GFH408 3.5 35.8 1.0
OG A:SER180 3.8 35.7 1.0
O1G A:GFH408 3.8 25.8 1.0
O3A A:GFH408 3.8 30.0 1.0
O A:HOH661 4.0 35.3 1.0
O A:HOH626 4.0 31.4 1.0
CZ A:ARG183 4.2 31.6 1.0
N A:SER180 4.3 31.5 1.0
CA A:SER180 4.4 30.6 1.0
NH1 A:ARG183 4.4 26.6 1.0
O A:HOH640 4.7 38.6 1.0
MG A:MG401 4.9 26.5 1.0

Reference:

V.K.Batra, S.H.Wilson. Ternary Complex Crystal Structure of K289M Variant of Dna Polymerase Beta with "Hot-Spot Sequence" with Beta-Gamma Chf Analogue of Dgtp To Be Published.
Page generated: Thu Aug 1 23:07:44 2024

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