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Fluorine in PDB 6nvj: FGFR4 Complex with N-(2-((5-((2,6-Dichloro-3,5-Dimethoxybenzyl)Oxy) Pyrimidin-2-Yl)Amino)-3-Fluorophenyl)AcrylamideEnzymatic activity of FGFR4 Complex with N-(2-((5-((2,6-Dichloro-3,5-Dimethoxybenzyl)Oxy) Pyrimidin-2-Yl)Amino)-3-Fluorophenyl)Acrylamide
All present enzymatic activity of FGFR4 Complex with N-(2-((5-((2,6-Dichloro-3,5-Dimethoxybenzyl)Oxy) Pyrimidin-2-Yl)Amino)-3-Fluorophenyl)Acrylamide:
2.7.10.1; Protein crystallography data
The structure of FGFR4 Complex with N-(2-((5-((2,6-Dichloro-3,5-Dimethoxybenzyl)Oxy) Pyrimidin-2-Yl)Amino)-3-Fluorophenyl)Acrylamide, PDB code: 6nvj
was solved by
X.Lin,
J.B.Smaill,
C.J.Squire,
Y.Yosaatmadja,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 6nvj:
The structure of FGFR4 Complex with N-(2-((5-((2,6-Dichloro-3,5-Dimethoxybenzyl)Oxy) Pyrimidin-2-Yl)Amino)-3-Fluorophenyl)Acrylamide also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the FGFR4 Complex with N-(2-((5-((2,6-Dichloro-3,5-Dimethoxybenzyl)Oxy) Pyrimidin-2-Yl)Amino)-3-Fluorophenyl)Acrylamide
(pdb code 6nvj). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the FGFR4 Complex with N-(2-((5-((2,6-Dichloro-3,5-Dimethoxybenzyl)Oxy) Pyrimidin-2-Yl)Amino)-3-Fluorophenyl)Acrylamide, PDB code: 6nvj: Fluorine binding site 1 out of 1 in 6nvjGo back to Fluorine Binding Sites List in 6nvj
Fluorine binding site 1 out
of 1 in the FGFR4 Complex with N-(2-((5-((2,6-Dichloro-3,5-Dimethoxybenzyl)Oxy) Pyrimidin-2-Yl)Amino)-3-Fluorophenyl)Acrylamide
Mono view Stereo pair view
Reference:
X.Lin,
Y.Yosaatmadja,
M.Kalyukina,
M.J.Middleditch,
Z.Zhang,
X.Lu,
K.Ding,
A.V.Patterson,
J.B.Smaill,
C.J.Squire.
Rotational Freedom, Steric Hindrance, and Protein Dynamics Explain BLU554 Selectivity For the Hinge Cysteine of FGFR4. Acs Med.Chem.Lett. V. 10 1180 2019.
Page generated: Sun Dec 13 13:01:07 2020
ISSN: ISSN 1948-5875 PubMed: 31413803 DOI: 10.1021/ACSMEDCHEMLETT.9B00196 |
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