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Fluorine in PDB 6oe3: Crystal Structure of Hiv-1 Reverse Transcriptase in Complex with 5-(2- (2-(2,4-Dioxo-3,4-Dihydropyrimidin-1(2H)-Yl)Ethoxy)Phenoxy)-7-Fluoro- 2-Naphthonitrile (JLJ635), A Non-Nucleoside InhibitorEnzymatic activity of Crystal Structure of Hiv-1 Reverse Transcriptase in Complex with 5-(2- (2-(2,4-Dioxo-3,4-Dihydropyrimidin-1(2H)-Yl)Ethoxy)Phenoxy)-7-Fluoro- 2-Naphthonitrile (JLJ635), A Non-Nucleoside Inhibitor
All present enzymatic activity of Crystal Structure of Hiv-1 Reverse Transcriptase in Complex with 5-(2- (2-(2,4-Dioxo-3,4-Dihydropyrimidin-1(2H)-Yl)Ethoxy)Phenoxy)-7-Fluoro- 2-Naphthonitrile (JLJ635), A Non-Nucleoside Inhibitor:
2.7.7.49; 2.7.7.7; 3.1.26.13; Protein crystallography data
The structure of Crystal Structure of Hiv-1 Reverse Transcriptase in Complex with 5-(2- (2-(2,4-Dioxo-3,4-Dihydropyrimidin-1(2H)-Yl)Ethoxy)Phenoxy)-7-Fluoro- 2-Naphthonitrile (JLJ635), A Non-Nucleoside Inhibitor, PDB code: 6oe3
was solved by
N.Bertoletti,
S.N.Kudalkar,
K.S.Anderson,
J.A.Cisneros Trigo,
W.L.Jorgensen,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 6oe3:
The structure of Crystal Structure of Hiv-1 Reverse Transcriptase in Complex with 5-(2- (2-(2,4-Dioxo-3,4-Dihydropyrimidin-1(2H)-Yl)Ethoxy)Phenoxy)-7-Fluoro- 2-Naphthonitrile (JLJ635), A Non-Nucleoside Inhibitor also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of Hiv-1 Reverse Transcriptase in Complex with 5-(2- (2-(2,4-Dioxo-3,4-Dihydropyrimidin-1(2H)-Yl)Ethoxy)Phenoxy)-7-Fluoro- 2-Naphthonitrile (JLJ635), A Non-Nucleoside Inhibitor
(pdb code 6oe3). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Crystal Structure of Hiv-1 Reverse Transcriptase in Complex with 5-(2- (2-(2,4-Dioxo-3,4-Dihydropyrimidin-1(2H)-Yl)Ethoxy)Phenoxy)-7-Fluoro- 2-Naphthonitrile (JLJ635), A Non-Nucleoside Inhibitor, PDB code: 6oe3: Fluorine binding site 1 out of 1 in 6oe3Go back to Fluorine Binding Sites List in 6oe3
Fluorine binding site 1 out
of 1 in the Crystal Structure of Hiv-1 Reverse Transcriptase in Complex with 5-(2- (2-(2,4-Dioxo-3,4-Dihydropyrimidin-1(2H)-Yl)Ethoxy)Phenoxy)-7-Fluoro- 2-Naphthonitrile (JLJ635), A Non-Nucleoside Inhibitor
Mono view Stereo pair view
Reference:
S.N.Kudalkar,
I.Ullah,
N.Bertoletti,
H.K.Mandl,
J.A.Cisneros,
J.Beloor,
A.H.Chan,
E.Quijano,
W.M.Saltzman,
W.L.Jorgensen,
P.Kumar,
K.S.Anderson.
Structural and Pharmacological Evaluation of A Novel Non-Nucleoside Reverse Transcriptase Inhibitor As A Promising Long Acting Nanoformulation For Treating Hiv. Antiviral Res. V. 167 110 2019.
Page generated: Sun Dec 13 13:01:56 2020
ISSN: ISSN 0166-3542 PubMed: 31034849 DOI: 10.1016/J.ANTIVIRAL.2019.04.010 |
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