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Atomistry » Fluorine » PDB 6onv-6p3p » 6p1d | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 6onv-6p3p » 6p1d » |
Fluorine in PDB 6p1d: Crystal Structure of Egfr with Mutant-Selective Dihydrodibenzodiazepinone Allosteric InhibitorEnzymatic activity of Crystal Structure of Egfr with Mutant-Selective Dihydrodibenzodiazepinone Allosteric Inhibitor
All present enzymatic activity of Crystal Structure of Egfr with Mutant-Selective Dihydrodibenzodiazepinone Allosteric Inhibitor:
2.7.10.1; Protein crystallography data
The structure of Crystal Structure of Egfr with Mutant-Selective Dihydrodibenzodiazepinone Allosteric Inhibitor, PDB code: 6p1d
was solved by
D.E.Heppner,
M.J.Eck,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 6p1d:
The structure of Crystal Structure of Egfr with Mutant-Selective Dihydrodibenzodiazepinone Allosteric Inhibitor also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of Egfr with Mutant-Selective Dihydrodibenzodiazepinone Allosteric Inhibitor
(pdb code 6p1d). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the Crystal Structure of Egfr with Mutant-Selective Dihydrodibenzodiazepinone Allosteric Inhibitor, PDB code: 6p1d: Jump to Fluorine binding site number: 1; 2; 3; Fluorine binding site 1 out of 3 in 6p1dGo back to Fluorine Binding Sites List in 6p1d
Fluorine binding site 1 out
of 3 in the Crystal Structure of Egfr with Mutant-Selective Dihydrodibenzodiazepinone Allosteric Inhibitor
Mono view Stereo pair view
Fluorine binding site 2 out of 3 in 6p1dGo back to Fluorine Binding Sites List in 6p1d
Fluorine binding site 2 out
of 3 in the Crystal Structure of Egfr with Mutant-Selective Dihydrodibenzodiazepinone Allosteric Inhibitor
Mono view Stereo pair view
Fluorine binding site 3 out of 3 in 6p1dGo back to Fluorine Binding Sites List in 6p1d
Fluorine binding site 3 out
of 3 in the Crystal Structure of Egfr with Mutant-Selective Dihydrodibenzodiazepinone Allosteric Inhibitor
Mono view Stereo pair view
Reference:
D.J.H.De Clercq,
D.E.Heppner,
C.To,
J.Jang,
E.Park,
C.H.Yun,
M.Mushajiang,
B.H.Shin,
T.W.Gero,
D.A.Scott,
P.A.Janne,
M.J.Eck,
N.S.Gray.
Discovery and Optimization of Dibenzodiazepinones As Allosteric Mutant-Selective Egfr Inhibitors. Acs Med.Chem.Lett. V. 10 1549 2019.
Page generated: Fri Aug 2 00:03:24 2024
ISSN: ISSN 1948-5875 PubMed: 31749909 DOI: 10.1021/ACSMEDCHEMLETT.9B00381 |
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