Fluorine in PDB 6pcs: E. Coli 50S Ribosome Bound to Compound 40E

The binding sites of Fluorine atom in the E. Coli 50S Ribosome Bound to Compound 40E (pdb code 6pcs). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the E. Coli 50S Ribosome Bound to Compound 40E, PDB code: 6pcs:
Jump to Fluorine binding site number: 1; 2; 3;

Fluorine binding site 1 out of 3 in the E. Coli 50S Ribosome Bound to Compound 40E


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of E. Coli 50S Ribosome Bound to Compound 40E within 5.0Å range: probe atom residue distance (Å) B Occ I:F3001 b:63.5 occ:1.00 F36 I:O8S3001 0.0 63.5 1.0 C35 I:O8S3001 1.3 63.5 1.0 F37 I:O8S3001 2.2 63.5 1.0 F38 I:O8S3001 2.2 63.5 1.0 C34 I:O8S3001 2.3 63.5 1.0 O2' I:A2602 2.4 70.7 1.0 C39 I:O8S3001 2.9 63.5 1.0 C2' I:A2602 3.2 70.7 1.0 C33 I:O8S3001 3.5 63.5 1.0 N9 I:A2602 4.0 70.7 1.0 C1' I:A2602 4.1 70.7 1.0 C4 I:A2602 4.1 70.7 1.0 C40 I:O8S3001 4.2 63.5 1.0 N3 I:A2602 4.2 70.7 1.0 C3' I:A2602 4.5 70.7 1.0 C8 I:A2602 4.6 70.7 1.0 C32 I:O8S3001 4.6 63.5 1.0 C5 I:A2602 4.7 70.7 1.0 C2 I:A2602 4.9 70.7 1.0 C31 I:O8S3001 4.9 63.5 1.0 N7 I:A2602 5.0 70.7 1.0

Fluorine binding site 2 out of 3 in the E. Coli 50S Ribosome Bound to Compound 40E


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of E. Coli 50S Ribosome Bound to Compound 40E within 5.0Å range: probe atom residue distance (Å) B Occ I:F3001 b:63.5 occ:1.00 F37 I:O8S3001 0.0 63.5 1.0 C35 I:O8S3001 1.3 63.5 1.0 F38 I:O8S3001 2.2 63.5 1.0 F36 I:O8S3001 2.2 63.5 1.0 C34 I:O8S3001 2.4 63.5 1.0 C33 I:O8S3001 2.8 63.5 1.0 C39 I:O8S3001 3.7 63.5 1.0 C32 I:O8S3001 4.2 63.5 1.0 O2' I:A2602 4.5 70.7 1.0 C40 I:O8S3001 4.8 63.5 1.0

Fluorine binding site 3 out of 3 in the E. Coli 50S Ribosome Bound to Compound 40E


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of E. Coli 50S Ribosome Bound to Compound 40E within 5.0Å range: probe atom residue distance (Å) B Occ I:F3001 b:63.5 occ:1.00 F38 I:O8S3001 0.0 63.5 1.0 C35 I:O8S3001 1.3 63.5 1.0 F37 I:O8S3001 2.2 63.5 1.0 F36 I:O8S3001 2.2 63.5 1.0 C34 I:O8S3001 2.3 63.5 1.0 C39 I:O8S3001 2.9 63.5 1.0 C33 I:O8S3001 3.4 63.5 1.0 O2' I:A2602 3.8 70.7 1.0 C40 I:O8S3001 4.2 63.5 1.0 C32 I:O8S3001 4.6 63.5 1.0 C31 I:O8S3001 4.9 63.5 1.0

J.Pellegrino, Q.Li, D.J.Lee, A.A.Tran, R.Wang, J.E.Park, K.Ji, D.Chow, N.Zhang, A.F.Brilot, J.T.Biel, G.Van Zundert, K.Borrelli, D.Shinabarger, C.Wolfe, B.Murray, M.P.Jacobson, I.B.Seiple, J.S.Fraser. Synthesis and Mechanism of Action of Group A Streptogramin Antibiotics That Overcome Resistance To Be Published.