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Fluorine in PDB 6pda: Crystal Structure of Myst Acetyltransferase Domain in Complex with Inhibitor 74
Enzymatic activity of Crystal Structure of Myst Acetyltransferase Domain in Complex with Inhibitor 74
All present enzymatic activity of Crystal Structure of Myst Acetyltransferase Domain in Complex with Inhibitor 74:
2.3.1.48;
2.3.1.48;
Protein crystallography data
The structure of Crystal Structure of Myst Acetyltransferase Domain in Complex with Inhibitor 74, PDB code: 6pda
was solved by
S.J.Hermans,
M.W.Parker,
T.Thomas,
J.B.Baell,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 42.99 / 2.45 |
| Space group | P 21 21 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 45.925, 56.214, 122.279, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 17.7 / 22.6 |
Other elements in 6pda:
The structure of Crystal Structure of Myst Acetyltransferase Domain in Complex with Inhibitor 74 also contains other interesting chemical elements:
| Zinc | (Zn) | 1 atom |
| Sodium | (Na) | 1 atom |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of Myst Acetyltransferase Domain in Complex with Inhibitor 74
(pdb code 6pda). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Crystal Structure of Myst Acetyltransferase Domain in Complex with Inhibitor 74, PDB code: 6pda:
In total only one binding site of Fluorine was determined in the Crystal Structure of Myst Acetyltransferase Domain in Complex with Inhibitor 74, PDB code: 6pda:
Fluorine binding site 1 out of 1 in 6pda
Go back to
Fluorine Binding Sites List in 6pda
Fluorine binding site 1 out
of 1 in the Crystal Structure of Myst Acetyltransferase Domain in Complex with Inhibitor 74
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Crystal Structure of Myst Acetyltransferase Domain in Complex with Inhibitor 74 within 5.0Å range:
|
Reference:
D.L.Priebbenow,
D.J.Leaver,
N.Nguyen,
B.Cleary,
H.R.Lagiakos,
J.Sanchez,
L.Xue,
F.Huang,
Y.Sun,
P.Mujumdar,
R.Mudududdla,
S.Varghese,
S.Teguh,
S.A.Charman,
K.L.White,
D.M.Shackleford,
K.Katneni,
M.Cuellar,
J.M.Strasser,
J.L.Dahlin,
M.A.Walters,
I.P.Street,
B.J.Monahan,
K.E.Jarman,
H.Jousset Sabroux,
H.Falk,
M.C.Chung,
S.J.Hermans,
N.L.Downer,
M.W.Parker,
A.K.Voss,
T.Thomas,
J.B.Baell.
Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, As Potent Senescence-Inducing Anti-Cancer Agents. J.Med.Chem. 2020.
ISSN: ISSN 0022-2623
PubMed: 32118427
DOI: 10.1021/ACS.JMEDCHEM.9B02071
Page generated: Fri Aug 2 00:13:30 2024
ISSN: ISSN 0022-2623
PubMed: 32118427
DOI: 10.1021/ACS.JMEDCHEM.9B02071
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