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Fluorine in PDB 6q2t: Human Sterol 14A-Demethylase (CYP51) in Complex with the Functionally Irreversible Inhibitor (R)-N-(1-(3-Chloro-4'-Fluoro-[1,1'-Biphenyl]- 4-Yl)-2-(1H-Imidazol-1-Yl)Ethyl)-4-(5-(3-Fluoro-5-(5-Fluoropyrimidin- 4-Yl)Phenyl)-1,3,4-Oxadiazol-2-Yl)Benzamide

Enzymatic activity of Human Sterol 14A-Demethylase (CYP51) in Complex with the Functionally Irreversible Inhibitor (R)-N-(1-(3-Chloro-4'-Fluoro-[1,1'-Biphenyl]- 4-Yl)-2-(1H-Imidazol-1-Yl)Ethyl)-4-(5-(3-Fluoro-5-(5-Fluoropyrimidin- 4-Yl)Phenyl)-1,3,4-Oxadiazol-2-Yl)Benzamide

All present enzymatic activity of Human Sterol 14A-Demethylase (CYP51) in Complex with the Functionally Irreversible Inhibitor (R)-N-(1-(3-Chloro-4'-Fluoro-[1,1'-Biphenyl]- 4-Yl)-2-(1H-Imidazol-1-Yl)Ethyl)-4-(5-(3-Fluoro-5-(5-Fluoropyrimidin- 4-Yl)Phenyl)-1,3,4-Oxadiazol-2-Yl)Benzamide:
1.14.13.70; 1.14.14.154;

Protein crystallography data

The structure of Human Sterol 14A-Demethylase (CYP51) in Complex with the Functionally Irreversible Inhibitor (R)-N-(1-(3-Chloro-4'-Fluoro-[1,1'-Biphenyl]- 4-Yl)-2-(1H-Imidazol-1-Yl)Ethyl)-4-(5-(3-Fluoro-5-(5-Fluoropyrimidin- 4-Yl)Phenyl)-1,3,4-Oxadiazol-2-Yl)Benzamide, PDB code: 6q2t was solved by L.Friggeri, T.Y.Hargrove, Z.Wawrzak, G.I.Lepesheva, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 28.10 / 2.80
Space group I 4
Cell size a, b, c (Å), α, β, γ (°) 117.664, 117.664, 157.842, 90.00, 90.00, 90.00
R / Rfree (%) 22.7 / 25.6

Other elements in 6q2t:

The structure of Human Sterol 14A-Demethylase (CYP51) in Complex with the Functionally Irreversible Inhibitor (R)-N-(1-(3-Chloro-4'-Fluoro-[1,1'-Biphenyl]- 4-Yl)-2-(1H-Imidazol-1-Yl)Ethyl)-4-(5-(3-Fluoro-5-(5-Fluoropyrimidin- 4-Yl)Phenyl)-1,3,4-Oxadiazol-2-Yl)Benzamide also contains other interesting chemical elements:

Iron (Fe) 2 atoms
Chlorine (Cl) 3 atoms

Fluorine Binding Sites:

The binding sites of Fluorine atom in the Human Sterol 14A-Demethylase (CYP51) in Complex with the Functionally Irreversible Inhibitor (R)-N-(1-(3-Chloro-4'-Fluoro-[1,1'-Biphenyl]- 4-Yl)-2-(1H-Imidazol-1-Yl)Ethyl)-4-(5-(3-Fluoro-5-(5-Fluoropyrimidin- 4-Yl)Phenyl)-1,3,4-Oxadiazol-2-Yl)Benzamide (pdb code 6q2t). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 9 binding sites of Fluorine where determined in the Human Sterol 14A-Demethylase (CYP51) in Complex with the Functionally Irreversible Inhibitor (R)-N-(1-(3-Chloro-4'-Fluoro-[1,1'-Biphenyl]- 4-Yl)-2-(1H-Imidazol-1-Yl)Ethyl)-4-(5-(3-Fluoro-5-(5-Fluoropyrimidin- 4-Yl)Phenyl)-1,3,4-Oxadiazol-2-Yl)Benzamide, PDB code: 6q2t:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9;

Fluorine binding site 1 out of 9 in 6q2t

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Fluorine binding site 1 out of 9 in the Human Sterol 14A-Demethylase (CYP51) in Complex with the Functionally Irreversible Inhibitor (R)-N-(1-(3-Chloro-4'-Fluoro-[1,1'-Biphenyl]- 4-Yl)-2-(1H-Imidazol-1-Yl)Ethyl)-4-(5-(3-Fluoro-5-(5-Fluoropyrimidin- 4-Yl)Phenyl)-1,3,4-Oxadiazol-2-Yl)Benzamide


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Human Sterol 14A-Demethylase (CYP51) in Complex with the Functionally Irreversible Inhibitor (R)-N-(1-(3-Chloro-4'-Fluoro-[1,1'-Biphenyl]- 4-Yl)-2-(1H-Imidazol-1-Yl)Ethyl)-4-(5-(3-Fluoro-5-(5-Fluoropyrimidin- 4-Yl)Phenyl)-1,3,4-Oxadiazol-2-Yl)Benzamide within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F602

b:0.8
occ:1.00
 F5 A:PJM602 0.0 0.8 1.0
C5 A:PJM602 1.4 0.5 1.0
C6 A:PJM602 2.4 0.2 1.0
C4 A:PJM602 2.4 0.6 1.0
CAV A:PJM602 2.6 0.4 1.0
CBQ A:PJM602 2.8 0.1 1.0
N3 A:PJM602 3.6 0.8 1.0
N1 A:PJM602 3.6 0.7 1.0
CZ2 A:TRP239 3.8 0.3 1.0
CBI A:PJM602 3.9 0.1 1.0
CZ A:PHE105 3.9 98.7 1.0
CH2 A:TRP239 4.0 91.1 1.0
CE2 A:PHE105 4.0 95.8 1.0
C2 A:PJM602 4.1 0.2 1.0
CAX A:PJM602 4.2 0.5 1.0
CE2 A:TRP239 4.3 0.2 1.0
FAC A:PJM602 4.4 92.3 1.0
CE A:MET381 4.7 0.6 1.0
CZ3 A:TRP239 4.7 96.4 1.0
CE1 A:PHE105 4.9 88.8 1.0
NE1 A:TRP239 4.9 0.6 1.0
SD A:MET100 4.9 70.0 1.0
CAU A:PJM602 4.9 0.9 1.0
C22 A:DXC609 5.0 0.9 1.0
CD2 A:TRP239 5.0 92.5 1.0

Fluorine binding site 2 out of 9 in 6q2t

Go back to Fluorine Binding Sites List in 6q2t
Fluorine binding site 2 out of 9 in the Human Sterol 14A-Demethylase (CYP51) in Complex with the Functionally Irreversible Inhibitor (R)-N-(1-(3-Chloro-4'-Fluoro-[1,1'-Biphenyl]- 4-Yl)-2-(1H-Imidazol-1-Yl)Ethyl)-4-(5-(3-Fluoro-5-(5-Fluoropyrimidin- 4-Yl)Phenyl)-1,3,4-Oxadiazol-2-Yl)Benzamide


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Human Sterol 14A-Demethylase (CYP51) in Complex with the Functionally Irreversible Inhibitor (R)-N-(1-(3-Chloro-4'-Fluoro-[1,1'-Biphenyl]- 4-Yl)-2-(1H-Imidazol-1-Yl)Ethyl)-4-(5-(3-Fluoro-5-(5-Fluoropyrimidin- 4-Yl)Phenyl)-1,3,4-Oxadiazol-2-Yl)Benzamide within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F602

b:92.3
occ:1.00
 FAC A:PJM602 0.0 92.3 1.0
CBI A:PJM602 1.4 0.1 1.0
CAV A:PJM602 2.4 0.4 1.0
CAU A:PJM602 2.4 0.9 1.0
CE3 A:TRP239 3.6 97.7 1.0
CBP A:PJM602 3.6 0.1 1.0
CBQ A:PJM602 3.7 0.1 1.0
CD2 A:TRP239 3.8 92.5 1.0
OE1 A:GLN400 4.0 0.2 1.0
CG A:TRP239 4.1 85.5 1.0
CAX A:PJM602 4.1 0.5 1.0
CB A:TRP239 4.2 88.3 1.0
CZ3 A:TRP239 4.2 96.4 1.0
F5 A:PJM602 4.4 0.8 1.0
CE2 A:TRP239 4.5 0.2 1.0
O A:TRP239 4.7 75.2 1.0
CBT A:PJM602 4.7 0.4 1.0
CD1 A:TRP239 4.8 0.9 1.0
C4 A:PJM602 4.8 0.6 1.0
CH2 A:TRP239 4.9 91.1 1.0
CD A:GLN400 4.9 0.9 1.0
CZ2 A:TRP239 5.0 0.3 1.0

Fluorine binding site 3 out of 9 in 6q2t

Go back to Fluorine Binding Sites List in 6q2t
Fluorine binding site 3 out of 9 in the Human Sterol 14A-Demethylase (CYP51) in Complex with the Functionally Irreversible Inhibitor (R)-N-(1-(3-Chloro-4'-Fluoro-[1,1'-Biphenyl]- 4-Yl)-2-(1H-Imidazol-1-Yl)Ethyl)-4-(5-(3-Fluoro-5-(5-Fluoropyrimidin- 4-Yl)Phenyl)-1,3,4-Oxadiazol-2-Yl)Benzamide


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Human Sterol 14A-Demethylase (CYP51) in Complex with the Functionally Irreversible Inhibitor (R)-N-(1-(3-Chloro-4'-Fluoro-[1,1'-Biphenyl]- 4-Yl)-2-(1H-Imidazol-1-Yl)Ethyl)-4-(5-(3-Fluoro-5-(5-Fluoropyrimidin- 4-Yl)Phenyl)-1,3,4-Oxadiazol-2-Yl)Benzamide within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F602

b:0.7
occ:1.00
 FAB A:PJM602 0.0 0.7 1.0
CBH A:PJM602 1.4 0.3 1.0
CAI A:PJM602 2.4 0.3 1.0
CAH A:PJM602 2.4 0.7 1.0
CD1 A:LEU159 3.1 0.3 1.0
CA A:MET304 3.6 84.2 1.0
CAM A:PJM602 3.6 0.4 1.0
CAL A:PJM602 3.6 0.9 1.0
CG A:MET304 3.7 97.8 1.0
O A:MET304 3.7 84.5 1.0
CB A:MET304 3.7 84.5 1.0
CD2 A:LEU159 4.1 0.7 1.0
CBM A:PJM602 4.1 96.9 1.0
CG A:LEU159 4.1 0.7 1.0
C A:MET304 4.2 87.8 1.0
CG1 A:VAL143 4.5 99.6 1.0
N A:LEU308 4.6 93.8 1.0
CA A:GLY307 4.6 77.5 1.0
CE A:MET304 4.8 0.4 1.0
N A:MET304 4.8 87.2 1.0
C A:GLY307 4.9 86.1 1.0
CG A:LEU308 5.0 0.9 1.0

Fluorine binding site 4 out of 9 in 6q2t

Go back to Fluorine Binding Sites List in 6q2t
Fluorine binding site 4 out of 9 in the Human Sterol 14A-Demethylase (CYP51) in Complex with the Functionally Irreversible Inhibitor (R)-N-(1-(3-Chloro-4'-Fluoro-[1,1'-Biphenyl]- 4-Yl)-2-(1H-Imidazol-1-Yl)Ethyl)-4-(5-(3-Fluoro-5-(5-Fluoropyrimidin- 4-Yl)Phenyl)-1,3,4-Oxadiazol-2-Yl)Benzamide


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of Human Sterol 14A-Demethylase (CYP51) in Complex with the Functionally Irreversible Inhibitor (R)-N-(1-(3-Chloro-4'-Fluoro-[1,1'-Biphenyl]- 4-Yl)-2-(1H-Imidazol-1-Yl)Ethyl)-4-(5-(3-Fluoro-5-(5-Fluoropyrimidin- 4-Yl)Phenyl)-1,3,4-Oxadiazol-2-Yl)Benzamide within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F611

b:73.7
occ:1.00
 F5 A:PJM611 0.0 73.7 1.0
C5 A:PJM611 1.4 90.1 1.0
C6 A:PJM611 2.4 0.0 1.0
C4 A:PJM611 2.4 95.8 1.0
CAV A:PJM611 2.5 0.6 1.0
CBQ A:PJM611 2.8 0.5 1.0
N3 A:PJM611 3.6 99.2 1.0
N1 A:PJM611 3.6 0.4 1.0
CBI A:PJM611 3.8 0.4 1.0
C2 A:PJM611 4.1 0.9 1.0
CAX A:PJM611 4.2 93.5 1.0
FAC A:PJM611 4.3 0.4 1.0
CAU A:PJM611 4.9 97.8 1.0

Fluorine binding site 5 out of 9 in 6q2t

Go back to Fluorine Binding Sites List in 6q2t
Fluorine binding site 5 out of 9 in the Human Sterol 14A-Demethylase (CYP51) in Complex with the Functionally Irreversible Inhibitor (R)-N-(1-(3-Chloro-4'-Fluoro-[1,1'-Biphenyl]- 4-Yl)-2-(1H-Imidazol-1-Yl)Ethyl)-4-(5-(3-Fluoro-5-(5-Fluoropyrimidin- 4-Yl)Phenyl)-1,3,4-Oxadiazol-2-Yl)Benzamide


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 5 of Human Sterol 14A-Demethylase (CYP51) in Complex with the Functionally Irreversible Inhibitor (R)-N-(1-(3-Chloro-4'-Fluoro-[1,1'-Biphenyl]- 4-Yl)-2-(1H-Imidazol-1-Yl)Ethyl)-4-(5-(3-Fluoro-5-(5-Fluoropyrimidin- 4-Yl)Phenyl)-1,3,4-Oxadiazol-2-Yl)Benzamide within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F611

b:0.4
occ:1.00
 FAC A:PJM611 0.0 0.4 1.0
CBI A:PJM611 1.4 0.4 1.0
CAU A:PJM611 2.4 97.8 1.0
CAV A:PJM611 2.4 0.6 1.0
CBP A:PJM611 3.6 89.8 1.0
CBQ A:PJM611 3.7 0.5 1.0
O A:HOH702 3.8 38.6 1.0
CAX A:PJM611 4.2 93.5 1.0
F5 A:PJM611 4.3 73.7 1.0
O1 A:DXC605 4.4 56.6 1.0
C24 A:DXC605 4.5 42.7 1.0
CBT A:PJM611 4.7 99.6 1.0
C4 A:PJM611 4.8 95.8 1.0
C6 A:DXC603 4.9 52.4 1.0

Fluorine binding site 6 out of 9 in 6q2t

Go back to Fluorine Binding Sites List in 6q2t
Fluorine binding site 6 out of 9 in the Human Sterol 14A-Demethylase (CYP51) in Complex with the Functionally Irreversible Inhibitor (R)-N-(1-(3-Chloro-4'-Fluoro-[1,1'-Biphenyl]- 4-Yl)-2-(1H-Imidazol-1-Yl)Ethyl)-4-(5-(3-Fluoro-5-(5-Fluoropyrimidin- 4-Yl)Phenyl)-1,3,4-Oxadiazol-2-Yl)Benzamide


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 6 of Human Sterol 14A-Demethylase (CYP51) in Complex with the Functionally Irreversible Inhibitor (R)-N-(1-(3-Chloro-4'-Fluoro-[1,1'-Biphenyl]- 4-Yl)-2-(1H-Imidazol-1-Yl)Ethyl)-4-(5-(3-Fluoro-5-(5-Fluoropyrimidin- 4-Yl)Phenyl)-1,3,4-Oxadiazol-2-Yl)Benzamide within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F611

b:0.1
occ:1.00
 FAB A:PJM611 0.0 0.1 1.0
CBH A:PJM611 1.4 0.2 1.0
CAI A:PJM611 2.4 0.8 1.0
CAH A:PJM611 2.4 0.5 1.0
CAM A:PJM611 3.7 0.1 1.0
CAL A:PJM611 3.7 0.4 1.0
CBM A:PJM611 4.2 0.2 1.0

Fluorine binding site 7 out of 9 in 6q2t

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Fluorine binding site 7 out of 9 in the Human Sterol 14A-Demethylase (CYP51) in Complex with the Functionally Irreversible Inhibitor (R)-N-(1-(3-Chloro-4'-Fluoro-[1,1'-Biphenyl]- 4-Yl)-2-(1H-Imidazol-1-Yl)Ethyl)-4-(5-(3-Fluoro-5-(5-Fluoropyrimidin- 4-Yl)Phenyl)-1,3,4-Oxadiazol-2-Yl)Benzamide


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 7 of Human Sterol 14A-Demethylase (CYP51) in Complex with the Functionally Irreversible Inhibitor (R)-N-(1-(3-Chloro-4'-Fluoro-[1,1'-Biphenyl]- 4-Yl)-2-(1H-Imidazol-1-Yl)Ethyl)-4-(5-(3-Fluoro-5-(5-Fluoropyrimidin- 4-Yl)Phenyl)-1,3,4-Oxadiazol-2-Yl)Benzamide within 5.0Å range:
probe atom residue distance (Å) B Occ
B:F602

b:0.2
occ:1.00
 F5 B:PJM602 0.0 0.2 1.0
C5 B:PJM602 1.4 0.3 1.0
C6 B:PJM602 2.4 0.1 1.0
C4 B:PJM602 2.4 0.7 1.0
CAV B:PJM602 2.6 0.7 1.0
CBQ B:PJM602 2.8 0.3 1.0
CZ2 B:TRP239 3.4 0.3 1.0
CH2 B:TRP239 3.6 0.3 1.0
N3 B:PJM602 3.6 1.0 1.0
N1 B:PJM602 3.7 0.6 1.0
CBI B:PJM602 3.8 0.8 1.0
CZ B:PHE105 3.9 88.1 1.0
CE2 B:TRP239 3.9 0.4 1.0
CE2 B:PHE105 4.1 77.2 1.0
C2 B:PJM602 4.1 0.5 1.0
CAX B:PJM602 4.2 0.5 1.0
CZ3 B:TRP239 4.3 0.5 1.0
FAC B:PJM602 4.4 86.5 1.0
NE1 B:TRP239 4.5 0.8 1.0
CD2 B:TRP239 4.5 0.6 1.0
CE3 B:TRP239 4.7 0.1 1.0
CE B:MET381 4.7 0.1 1.0
CE1 B:PHE105 4.8 79.6 1.0
SD B:MET381 4.8 0.7 1.0
CAU B:PJM602 4.9 0.1 1.0

Fluorine binding site 8 out of 9 in 6q2t

Go back to Fluorine Binding Sites List in 6q2t
Fluorine binding site 8 out of 9 in the Human Sterol 14A-Demethylase (CYP51) in Complex with the Functionally Irreversible Inhibitor (R)-N-(1-(3-Chloro-4'-Fluoro-[1,1'-Biphenyl]- 4-Yl)-2-(1H-Imidazol-1-Yl)Ethyl)-4-(5-(3-Fluoro-5-(5-Fluoropyrimidin- 4-Yl)Phenyl)-1,3,4-Oxadiazol-2-Yl)Benzamide


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 8 of Human Sterol 14A-Demethylase (CYP51) in Complex with the Functionally Irreversible Inhibitor (R)-N-(1-(3-Chloro-4'-Fluoro-[1,1'-Biphenyl]- 4-Yl)-2-(1H-Imidazol-1-Yl)Ethyl)-4-(5-(3-Fluoro-5-(5-Fluoropyrimidin- 4-Yl)Phenyl)-1,3,4-Oxadiazol-2-Yl)Benzamide within 5.0Å range:
probe atom residue distance (Å) B Occ
B:F602

b:86.5
occ:1.00
 FAC B:PJM602 0.0 86.5 1.0
CBI B:PJM602 1.4 0.8 1.0
CAV B:PJM602 2.4 0.7 1.0
CAU B:PJM602 2.4 0.1 1.0
CE3 B:TRP239 3.2 0.1 1.0
O B:HOH716 3.3 77.8 1.0
CD2 B:TRP239 3.6 0.6 1.0
CBQ B:PJM602 3.7 0.3 1.0
CBP B:PJM602 3.7 0.3 1.0
CZ3 B:TRP239 3.7 0.5 1.0
OE1 B:GLN400 3.8 96.7 1.0
CG B:TRP239 4.1 83.0 1.0
CAX B:PJM602 4.1 0.5 1.0
CB B:TRP239 4.3 81.5 1.0
F5 B:PJM602 4.4 0.2 1.0
CE2 B:TRP239 4.5 0.4 1.0
CH2 B:TRP239 4.6 0.3 1.0
CE B:MET381 4.7 0.1 1.0
CBT B:PJM602 4.8 0.0 1.0
C4 B:PJM602 4.8 0.7 1.0
CZ2 B:TRP239 4.9 0.3 1.0
CD B:GLN400 4.9 88.3 1.0
NH2 B:ARG133 5.0 0.1 1.0
O B:VAL130 5.0 82.5 1.0

Fluorine binding site 9 out of 9 in 6q2t

Go back to Fluorine Binding Sites List in 6q2t
Fluorine binding site 9 out of 9 in the Human Sterol 14A-Demethylase (CYP51) in Complex with the Functionally Irreversible Inhibitor (R)-N-(1-(3-Chloro-4'-Fluoro-[1,1'-Biphenyl]- 4-Yl)-2-(1H-Imidazol-1-Yl)Ethyl)-4-(5-(3-Fluoro-5-(5-Fluoropyrimidin- 4-Yl)Phenyl)-1,3,4-Oxadiazol-2-Yl)Benzamide


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 9 of Human Sterol 14A-Demethylase (CYP51) in Complex with the Functionally Irreversible Inhibitor (R)-N-(1-(3-Chloro-4'-Fluoro-[1,1'-Biphenyl]- 4-Yl)-2-(1H-Imidazol-1-Yl)Ethyl)-4-(5-(3-Fluoro-5-(5-Fluoropyrimidin- 4-Yl)Phenyl)-1,3,4-Oxadiazol-2-Yl)Benzamide within 5.0Å range:
probe atom residue distance (Å) B Occ
B:F602

b:86.4
occ:1.00
 FAB B:PJM602 0.0 86.4 1.0
CBH B:PJM602 1.4 87.2 1.0
CAI B:PJM602 2.4 82.3 1.0
CAH B:PJM602 2.4 98.0 1.0
CA B:MET304 3.4 70.2 1.0
O B:MET304 3.6 62.0 1.0
CD1 B:LEU159 3.6 97.4 1.0
CAM B:PJM602 3.6 85.7 1.0
CAL B:PJM602 3.6 96.8 1.0
CG B:MET304 3.7 77.7 1.0
CB B:MET304 3.8 69.3 1.0
C B:MET304 4.0 67.2 1.0
CG1 B:VAL143 4.1 86.5 1.0
CBM B:PJM602 4.1 89.2 1.0
CD2 B:LEU159 4.5 95.5 1.0
N B:MET304 4.6 75.0 1.0
CA B:GLY307 4.7 64.8 1.0
CG B:LEU159 4.7 0.1 1.0
N B:LEU308 4.7 67.1 1.0
O B:GLY303 4.8 90.5 1.0
C B:GLY307 4.9 67.9 1.0

Reference:

L.Friggeri, T.Y.Hargrove, Z.Wawrzak, F.P.Guengerich, G.I.Lepesheva. Validation of Human Sterol 14 Alpha-Demethylase (CYP51) Druggability: Structure-Guided Design, Synthesis and Evaluation of Stoichiometric, Functionally Irreversible Inhibitors. J.Med.Chem. 2019.
ISSN: ISSN 0022-2623
PubMed: 31663733
DOI: 10.1021/ACS.JMEDCHEM.9B01485
Page generated: Fri Aug 2 00:41:10 2024

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