Fluorine in PDB 6q7w: Crystal Structure of Pqsr (Mvfr) Ligand-Binding Domain in Complex with Compound 20
Protein crystallography data
The structure of Crystal Structure of Pqsr (Mvfr) Ligand-Binding Domain in Complex with Compound 20, PDB code: 6q7w
was solved by
F.Witzgall,
W.Blankenfeldt,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Resolution Low / High (Å)
|
47.72 /
2.82
|
Space group
|
P 65 2 2
|
Cell size a, b, c (Å), α, β, γ (°)
|
121.218,
121.218,
114.555,
90.00,
90.00,
120.00
|
R / Rfree (%)
|
23.1 /
26.2
|
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of Pqsr (Mvfr) Ligand-Binding Domain in Complex with Compound 20
(pdb code 6q7w). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 4 binding sites of Fluorine where determined in the
Crystal Structure of Pqsr (Mvfr) Ligand-Binding Domain in Complex with Compound 20, PDB code: 6q7w:
Jump to Fluorine binding site number:
1;
2;
3;
4;
Fluorine binding site 1 out
of 4 in 6q7w
Go back to
Fluorine Binding Sites List in 6q7w
Fluorine binding site 1 out
of 4 in the Crystal Structure of Pqsr (Mvfr) Ligand-Binding Domain in Complex with Compound 20
Mono view
Stereo pair view
|
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Crystal Structure of Pqsr (Mvfr) Ligand-Binding Domain in Complex with Compound 20 within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:F400
b:80.7
occ:1.00
|
F07
|
A:HLQ400
|
0.0
|
80.7
|
1.0
|
C06
|
A:HLQ400
|
1.4
|
83.7
|
1.0
|
C05
|
A:HLQ400
|
2.4
|
87.7
|
1.0
|
C01
|
A:HLQ400
|
2.4
|
85.1
|
1.0
|
H051
|
A:HLQ400
|
2.6
|
0.3
|
1.0
|
H011
|
A:HLQ400
|
2.6
|
0.1
|
1.0
|
HD12
|
A:LEU189
|
2.8
|
0.7
|
1.0
|
HG21
|
A:VAL170
|
3.1
|
65.8
|
1.0
|
HD13
|
A:LEU189
|
3.2
|
0.7
|
1.0
|
CD1
|
A:LEU189
|
3.3
|
0.5
|
1.0
|
HD11
|
A:LEU189
|
3.4
|
0.7
|
1.0
|
C04
|
A:HLQ400
|
3.6
|
85.7
|
1.0
|
C02
|
A:HLQ400
|
3.6
|
87.1
|
1.0
|
HG23
|
A:ILE186
|
3.9
|
0.9
|
1.0
|
CG2
|
A:VAL170
|
3.9
|
59.2
|
1.0
|
C03
|
A:HLQ400
|
4.1
|
84.7
|
1.0
|
HG22
|
A:VAL170
|
4.2
|
65.8
|
1.0
|
HG23
|
A:VAL170
|
4.2
|
65.8
|
1.0
|
H041
|
A:HLQ400
|
4.4
|
0.9
|
1.0
|
H021
|
A:HLQ400
|
4.4
|
0.6
|
1.0
|
HG11
|
A:VAL170
|
4.5
|
80.7
|
1.0
|
HB3
|
A:SER255
|
4.6
|
79.3
|
1.0
|
HD11
|
A:ILE263
|
4.7
|
68.1
|
1.0
|
CG2
|
A:ILE186
|
4.8
|
0.4
|
1.0
|
CG
|
A:LEU189
|
4.8
|
0.8
|
1.0
|
HB2
|
A:LEU189
|
4.9
|
0.7
|
1.0
|
HG21
|
A:ILE186
|
4.9
|
0.9
|
1.0
|
HG11
|
A:VAL211
|
4.9
|
0.9
|
1.0
|
HB2
|
A:TYR258
|
4.9
|
69.2
|
1.0
|
HD13
|
A:ILE263
|
4.9
|
68.1
|
1.0
|
CD2
|
A:TYR258
|
4.9
|
56.4
|
1.0
|
|
Fluorine binding site 2 out
of 4 in 6q7w
Go back to
Fluorine Binding Sites List in 6q7w
Fluorine binding site 2 out
of 4 in the Crystal Structure of Pqsr (Mvfr) Ligand-Binding Domain in Complex with Compound 20
Mono view
Stereo pair view
|
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Crystal Structure of Pqsr (Mvfr) Ligand-Binding Domain in Complex with Compound 20 within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:F400
b:64.6
occ:1.00
|
F20
|
A:HLQ400
|
0.0
|
64.6
|
1.0
|
C19
|
A:HLQ400
|
1.4
|
64.6
|
1.0
|
F21
|
A:HLQ400
|
2.2
|
65.5
|
1.0
|
F22
|
A:HLQ400
|
2.2
|
60.8
|
1.0
|
H131
|
A:HLQ400
|
2.3
|
85.5
|
1.0
|
C14
|
A:HLQ400
|
2.4
|
67.2
|
1.0
|
C13
|
A:HLQ400
|
2.7
|
70.4
|
1.0
|
HB2
|
A:ALA168
|
2.8
|
57.2
|
1.0
|
HD13
|
A:ILE149
|
3.0
|
72.6
|
1.0
|
HD12
|
A:ILE149
|
3.1
|
72.6
|
1.0
|
HB1
|
A:ALA168
|
3.2
|
57.2
|
1.0
|
CD1
|
A:ILE149
|
3.4
|
59.6
|
1.0
|
CB
|
A:ALA168
|
3.4
|
49.7
|
1.0
|
HD11
|
A:ILE149
|
3.4
|
72.6
|
1.0
|
N15
|
A:HLQ400
|
3.6
|
66.0
|
1.0
|
HG3
|
A:PRO238
|
3.7
|
68.6
|
1.0
|
HB1
|
A:ALA102
|
3.7
|
69.0
|
1.0
|
HG21
|
A:THR265
|
3.8
|
65.6
|
1.0
|
HB3
|
A:ALA168
|
3.8
|
57.2
|
1.0
|
HG22
|
A:ILE236
|
4.1
|
68.3
|
1.0
|
C12
|
A:HLQ400
|
4.1
|
71.0
|
1.0
|
HA
|
A:PRO238
|
4.1
|
68.2
|
1.0
|
HB2
|
A:ALA102
|
4.3
|
69.0
|
1.0
|
CB
|
A:ALA102
|
4.5
|
56.6
|
1.0
|
HD3
|
A:PRO238
|
4.5
|
70.0
|
1.0
|
HG21
|
A:ILE149
|
4.5
|
70.6
|
1.0
|
HZ
|
A:PHE221
|
4.5
|
74.6
|
1.0
|
CG
|
A:PRO238
|
4.5
|
57.0
|
1.0
|
N
|
A:PRO238
|
4.5
|
58.3
|
1.0
|
OG1
|
A:THR265
|
4.6
|
51.0
|
1.0
|
HA
|
A:ALA168
|
4.6
|
64.1
|
1.0
|
C16
|
A:HLQ400
|
4.7
|
65.8
|
1.0
|
CA
|
A:ALA168
|
4.7
|
52.5
|
1.0
|
HB3
|
A:PRO238
|
4.7
|
69.1
|
1.0
|
CA
|
A:PRO238
|
4.7
|
58.0
|
1.0
|
CG2
|
A:THR265
|
4.7
|
53.8
|
1.0
|
C
|
A:ALA237
|
4.7
|
58.5
|
1.0
|
HB
|
A:THR265
|
4.8
|
62.7
|
1.0
|
CD
|
A:PRO238
|
4.8
|
58.4
|
1.0
|
HG21
|
A:ILE236
|
4.8
|
68.3
|
1.0
|
CG2
|
A:ILE236
|
4.9
|
56.0
|
1.0
|
CG1
|
A:ILE149
|
4.9
|
59.5
|
1.0
|
HA
|
A:ALA237
|
4.9
|
73.6
|
1.0
|
C17
|
A:HLQ400
|
4.9
|
69.6
|
1.0
|
CB
|
A:PRO238
|
4.9
|
57.6
|
1.0
|
O
|
A:ALA237
|
4.9
|
58.2
|
1.0
|
HB3
|
A:ALA102
|
4.9
|
69.0
|
1.0
|
N11
|
A:HLQ400
|
5.0
|
72.5
|
1.0
|
CB
|
A:THR265
|
5.0
|
51.4
|
1.0
|
|
Fluorine binding site 3 out
of 4 in 6q7w
Go back to
Fluorine Binding Sites List in 6q7w
Fluorine binding site 3 out
of 4 in the Crystal Structure of Pqsr (Mvfr) Ligand-Binding Domain in Complex with Compound 20
Mono view
Stereo pair view
|
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Crystal Structure of Pqsr (Mvfr) Ligand-Binding Domain in Complex with Compound 20 within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:F400
b:65.5
occ:1.00
|
F21
|
A:HLQ400
|
0.0
|
65.5
|
1.0
|
C19
|
A:HLQ400
|
1.4
|
64.6
|
1.0
|
F20
|
A:HLQ400
|
2.2
|
64.6
|
1.0
|
F22
|
A:HLQ400
|
2.2
|
60.8
|
1.0
|
C14
|
A:HLQ400
|
2.4
|
67.2
|
1.0
|
HG22
|
A:ILE236
|
2.6
|
68.3
|
1.0
|
N15
|
A:HLQ400
|
2.9
|
66.0
|
1.0
|
HA
|
A:ALA237
|
3.0
|
73.6
|
1.0
|
HD3
|
A:PRO238
|
3.3
|
70.0
|
1.0
|
HB1
|
A:ALA168
|
3.3
|
57.2
|
1.0
|
C13
|
A:HLQ400
|
3.4
|
70.4
|
1.0
|
O
|
A:ILE236
|
3.4
|
57.1
|
1.0
|
C
|
A:ALA237
|
3.4
|
58.5
|
1.0
|
CA
|
A:ALA237
|
3.4
|
60.4
|
1.0
|
HE2
|
A:PHE221
|
3.5
|
83.6
|
1.0
|
O
|
A:HOH508
|
3.5
|
39.0
|
1.0
|
N
|
A:ALA237
|
3.5
|
58.4
|
1.0
|
C
|
A:ILE236
|
3.5
|
57.4
|
1.0
|
CG2
|
A:ILE236
|
3.6
|
56.0
|
1.0
|
H131
|
A:HLQ400
|
3.6
|
85.5
|
1.0
|
HZ
|
A:PHE221
|
3.6
|
74.6
|
1.0
|
N
|
A:PRO238
|
3.6
|
58.3
|
1.0
|
HG3
|
A:PRO238
|
3.8
|
68.6
|
1.0
|
HB2
|
A:ALA168
|
3.8
|
57.2
|
1.0
|
HG21
|
A:ILE236
|
3.8
|
68.3
|
1.0
|
CD
|
A:PRO238
|
3.9
|
58.4
|
1.0
|
O
|
A:ALA237
|
3.9
|
58.2
|
1.0
|
HB
|
A:ILE236
|
4.0
|
68.7
|
1.0
|
CB
|
A:ALA168
|
4.0
|
49.7
|
1.0
|
H
|
A:ALA237
|
4.0
|
69.6
|
1.0
|
CE2
|
A:PHE221
|
4.0
|
68.8
|
1.0
|
CZ
|
A:PHE221
|
4.1
|
66.5
|
1.0
|
C16
|
A:HLQ400
|
4.2
|
65.8
|
1.0
|
HA
|
A:PRO238
|
4.2
|
68.2
|
1.0
|
HG23
|
A:ILE236
|
4.2
|
68.3
|
1.0
|
CB
|
A:ILE236
|
4.2
|
56.4
|
1.0
|
CG
|
A:PRO238
|
4.3
|
57.0
|
1.0
|
CA
|
A:PRO238
|
4.5
|
58.0
|
1.0
|
CA
|
A:ILE236
|
4.5
|
56.9
|
1.0
|
C12
|
A:HLQ400
|
4.6
|
71.0
|
1.0
|
HB3
|
A:ALA168
|
4.6
|
57.2
|
1.0
|
HD11
|
A:ILE149
|
4.6
|
72.6
|
1.0
|
HD2
|
A:PRO238
|
4.7
|
70.0
|
1.0
|
HD13
|
A:ILE149
|
4.7
|
72.6
|
1.0
|
HA
|
A:ALA168
|
4.8
|
64.1
|
1.0
|
HB1
|
A:ALA102
|
4.8
|
69.0
|
1.0
|
C17
|
A:HLQ400
|
4.9
|
69.6
|
1.0
|
HD12
|
A:ILE149
|
4.9
|
72.6
|
1.0
|
HB2
|
A:ALA102
|
4.9
|
69.0
|
1.0
|
HA
|
A:ILE236
|
4.9
|
67.8
|
1.0
|
CB
|
A:ALA237
|
4.9
|
65.4
|
1.0
|
CD1
|
A:ILE149
|
5.0
|
59.6
|
1.0
|
|
Fluorine binding site 4 out
of 4 in 6q7w
Go back to
Fluorine Binding Sites List in 6q7w
Fluorine binding site 4 out
of 4 in the Crystal Structure of Pqsr (Mvfr) Ligand-Binding Domain in Complex with Compound 20
Mono view
Stereo pair view
|
A full contact list of Fluorine with other atoms in the F binding
site number 4 of Crystal Structure of Pqsr (Mvfr) Ligand-Binding Domain in Complex with Compound 20 within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:F400
b:60.8
occ:1.00
|
F22
|
A:HLQ400
|
0.0
|
60.8
|
1.0
|
C19
|
A:HLQ400
|
1.4
|
64.6
|
1.0
|
F21
|
A:HLQ400
|
2.2
|
65.5
|
1.0
|
F20
|
A:HLQ400
|
2.2
|
64.6
|
1.0
|
C14
|
A:HLQ400
|
2.4
|
67.2
|
1.0
|
HD11
|
A:ILE149
|
2.6
|
72.6
|
1.0
|
HZ
|
A:PHE221
|
2.7
|
74.6
|
1.0
|
N15
|
A:HLQ400
|
2.9
|
66.0
|
1.0
|
HD13
|
A:ILE149
|
3.0
|
72.6
|
1.0
|
CD1
|
A:ILE149
|
3.1
|
59.6
|
1.0
|
HB2
|
A:ALA102
|
3.2
|
69.0
|
1.0
|
HD12
|
A:ILE149
|
3.3
|
72.6
|
1.0
|
C13
|
A:HLQ400
|
3.5
|
70.4
|
1.0
|
CZ
|
A:PHE221
|
3.5
|
66.5
|
1.0
|
HB1
|
A:ALA102
|
3.5
|
69.0
|
1.0
|
HG2
|
A:PRO129
|
3.6
|
84.1
|
1.0
|
H131
|
A:HLQ400
|
3.7
|
85.5
|
1.0
|
O
|
A:HOH508
|
3.8
|
39.0
|
1.0
|
HG3
|
A:PRO238
|
3.8
|
68.6
|
1.0
|
CB
|
A:ALA102
|
3.8
|
56.6
|
1.0
|
HE2
|
A:PHE221
|
3.9
|
83.6
|
1.0
|
HD3
|
A:PRO238
|
4.0
|
70.0
|
1.0
|
C16
|
A:HLQ400
|
4.1
|
65.8
|
1.0
|
CE2
|
A:PHE221
|
4.1
|
68.8
|
1.0
|
HD21
|
A:LEU208
|
4.2
|
85.5
|
1.0
|
HB3
|
A:ALA102
|
4.3
|
69.0
|
1.0
|
HD12
|
A:LEU197
|
4.3
|
92.7
|
1.0
|
HD22
|
A:LEU208
|
4.4
|
85.5
|
1.0
|
CG
|
A:PRO129
|
4.4
|
69.2
|
1.0
|
HD11
|
A:LEU197
|
4.5
|
92.7
|
1.0
|
CG1
|
A:ILE149
|
4.5
|
59.5
|
1.0
|
CE1
|
A:PHE221
|
4.5
|
68.3
|
1.0
|
HG22
|
A:ILE236
|
4.6
|
68.3
|
1.0
|
HE1
|
A:PHE221
|
4.6
|
76.8
|
1.0
|
HA
|
A:ALA237
|
4.6
|
73.6
|
1.0
|
HB2
|
A:PRO129
|
4.6
|
83.8
|
1.0
|
C12
|
A:HLQ400
|
4.6
|
71.0
|
1.0
|
CG
|
A:PRO238
|
4.6
|
57.0
|
1.0
|
HG3
|
A:PRO129
|
4.6
|
84.1
|
1.0
|
HG12
|
A:ILE149
|
4.7
|
72.4
|
1.0
|
CD2
|
A:LEU208
|
4.7
|
70.4
|
1.0
|
CD
|
A:PRO238
|
4.7
|
58.4
|
1.0
|
HB3
|
A:PRO129
|
4.7
|
83.8
|
1.0
|
CB
|
A:PRO129
|
4.8
|
68.9
|
1.0
|
HD23
|
A:LEU208
|
4.8
|
85.5
|
1.0
|
HG13
|
A:ILE149
|
4.8
|
72.4
|
1.0
|
C17
|
A:HLQ400
|
4.9
|
69.6
|
1.0
|
CD1
|
A:LEU197
|
4.9
|
76.4
|
1.0
|
HA
|
A:ALA102
|
4.9
|
71.5
|
1.0
|
HB2
|
A:ALA168
|
4.9
|
57.2
|
1.0
|
O
|
A:ILE236
|
4.9
|
57.1
|
1.0
|
HB1
|
A:ALA168
|
5.0
|
57.2
|
1.0
|
|
Reference:
M.Zender,
F.Witzgall,
A.F.Kiefer,
B.Kirsch,
C.K.Maurer,
A.M.Kany,
N.Xu,
S.Schmelz,
C.Borger,
W.Blankenfeldt,
M.Empting.
Flexible Fragment Growing Boosts Potency of Quorum Sensing Inhibitors Against Pseudomonas Aeruginosa Virulence. Chemmedchem 2019.
ISSN: ESSN 1860-7187
PubMed: 31709767
DOI: 10.1002/CMDC.201900621
Page generated: Fri Aug 2 00:43:39 2024
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