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Fluorine in PDB 6q7w: Crystal Structure of Pqsr (Mvfr) Ligand-Binding Domain in Complex with Compound 20

Protein crystallography data

The structure of Crystal Structure of Pqsr (Mvfr) Ligand-Binding Domain in Complex with Compound 20, PDB code: 6q7w was solved by F.Witzgall, W.Blankenfeldt, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 47.72 / 2.82
Space group P 65 2 2
Cell size a, b, c (Å), α, β, γ (°) 121.218, 121.218, 114.555, 90.00, 90.00, 120.00
R / Rfree (%) 23.1 / 26.2

Fluorine Binding Sites:

The binding sites of Fluorine atom in the Crystal Structure of Pqsr (Mvfr) Ligand-Binding Domain in Complex with Compound 20 (pdb code 6q7w). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 4 binding sites of Fluorine where determined in the Crystal Structure of Pqsr (Mvfr) Ligand-Binding Domain in Complex with Compound 20, PDB code: 6q7w:
Jump to Fluorine binding site number: 1; 2; 3; 4;

Fluorine binding site 1 out of 4 in 6q7w

Go back to Fluorine Binding Sites List in 6q7w
Fluorine binding site 1 out of 4 in the Crystal Structure of Pqsr (Mvfr) Ligand-Binding Domain in Complex with Compound 20


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Crystal Structure of Pqsr (Mvfr) Ligand-Binding Domain in Complex with Compound 20 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F400

b:80.7
occ:1.00
F07 A:HLQ400 0.0 80.7 1.0
C06 A:HLQ400 1.4 83.7 1.0
C05 A:HLQ400 2.4 87.7 1.0
C01 A:HLQ400 2.4 85.1 1.0
H051 A:HLQ400 2.6 0.3 1.0
H011 A:HLQ400 2.6 0.1 1.0
HD12 A:LEU189 2.8 0.7 1.0
HG21 A:VAL170 3.1 65.8 1.0
HD13 A:LEU189 3.2 0.7 1.0
CD1 A:LEU189 3.3 0.5 1.0
HD11 A:LEU189 3.4 0.7 1.0
C04 A:HLQ400 3.6 85.7 1.0
C02 A:HLQ400 3.6 87.1 1.0
HG23 A:ILE186 3.9 0.9 1.0
CG2 A:VAL170 3.9 59.2 1.0
C03 A:HLQ400 4.1 84.7 1.0
HG22 A:VAL170 4.2 65.8 1.0
HG23 A:VAL170 4.2 65.8 1.0
H041 A:HLQ400 4.4 0.9 1.0
H021 A:HLQ400 4.4 0.6 1.0
HG11 A:VAL170 4.5 80.7 1.0
HB3 A:SER255 4.6 79.3 1.0
HD11 A:ILE263 4.7 68.1 1.0
CG2 A:ILE186 4.8 0.4 1.0
CG A:LEU189 4.8 0.8 1.0
HB2 A:LEU189 4.9 0.7 1.0
HG21 A:ILE186 4.9 0.9 1.0
HG11 A:VAL211 4.9 0.9 1.0
HB2 A:TYR258 4.9 69.2 1.0
HD13 A:ILE263 4.9 68.1 1.0
CD2 A:TYR258 4.9 56.4 1.0

Fluorine binding site 2 out of 4 in 6q7w

Go back to Fluorine Binding Sites List in 6q7w
Fluorine binding site 2 out of 4 in the Crystal Structure of Pqsr (Mvfr) Ligand-Binding Domain in Complex with Compound 20


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Crystal Structure of Pqsr (Mvfr) Ligand-Binding Domain in Complex with Compound 20 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F400

b:64.6
occ:1.00
F20 A:HLQ400 0.0 64.6 1.0
C19 A:HLQ400 1.4 64.6 1.0
F21 A:HLQ400 2.2 65.5 1.0
F22 A:HLQ400 2.2 60.8 1.0
H131 A:HLQ400 2.3 85.5 1.0
C14 A:HLQ400 2.4 67.2 1.0
C13 A:HLQ400 2.7 70.4 1.0
HB2 A:ALA168 2.8 57.2 1.0
HD13 A:ILE149 3.0 72.6 1.0
HD12 A:ILE149 3.1 72.6 1.0
HB1 A:ALA168 3.2 57.2 1.0
CD1 A:ILE149 3.4 59.6 1.0
CB A:ALA168 3.4 49.7 1.0
HD11 A:ILE149 3.4 72.6 1.0
N15 A:HLQ400 3.6 66.0 1.0
HG3 A:PRO238 3.7 68.6 1.0
HB1 A:ALA102 3.7 69.0 1.0
HG21 A:THR265 3.8 65.6 1.0
HB3 A:ALA168 3.8 57.2 1.0
HG22 A:ILE236 4.1 68.3 1.0
C12 A:HLQ400 4.1 71.0 1.0
HA A:PRO238 4.1 68.2 1.0
HB2 A:ALA102 4.3 69.0 1.0
CB A:ALA102 4.5 56.6 1.0
HD3 A:PRO238 4.5 70.0 1.0
HG21 A:ILE149 4.5 70.6 1.0
HZ A:PHE221 4.5 74.6 1.0
CG A:PRO238 4.5 57.0 1.0
N A:PRO238 4.5 58.3 1.0
OG1 A:THR265 4.6 51.0 1.0
HA A:ALA168 4.6 64.1 1.0
C16 A:HLQ400 4.7 65.8 1.0
CA A:ALA168 4.7 52.5 1.0
HB3 A:PRO238 4.7 69.1 1.0
CA A:PRO238 4.7 58.0 1.0
CG2 A:THR265 4.7 53.8 1.0
C A:ALA237 4.7 58.5 1.0
HB A:THR265 4.8 62.7 1.0
CD A:PRO238 4.8 58.4 1.0
HG21 A:ILE236 4.8 68.3 1.0
CG2 A:ILE236 4.9 56.0 1.0
CG1 A:ILE149 4.9 59.5 1.0
HA A:ALA237 4.9 73.6 1.0
C17 A:HLQ400 4.9 69.6 1.0
CB A:PRO238 4.9 57.6 1.0
O A:ALA237 4.9 58.2 1.0
HB3 A:ALA102 4.9 69.0 1.0
N11 A:HLQ400 5.0 72.5 1.0
CB A:THR265 5.0 51.4 1.0

Fluorine binding site 3 out of 4 in 6q7w

Go back to Fluorine Binding Sites List in 6q7w
Fluorine binding site 3 out of 4 in the Crystal Structure of Pqsr (Mvfr) Ligand-Binding Domain in Complex with Compound 20


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Crystal Structure of Pqsr (Mvfr) Ligand-Binding Domain in Complex with Compound 20 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F400

b:65.5
occ:1.00
F21 A:HLQ400 0.0 65.5 1.0
C19 A:HLQ400 1.4 64.6 1.0
F20 A:HLQ400 2.2 64.6 1.0
F22 A:HLQ400 2.2 60.8 1.0
C14 A:HLQ400 2.4 67.2 1.0
HG22 A:ILE236 2.6 68.3 1.0
N15 A:HLQ400 2.9 66.0 1.0
HA A:ALA237 3.0 73.6 1.0
HD3 A:PRO238 3.3 70.0 1.0
HB1 A:ALA168 3.3 57.2 1.0
C13 A:HLQ400 3.4 70.4 1.0
O A:ILE236 3.4 57.1 1.0
C A:ALA237 3.4 58.5 1.0
CA A:ALA237 3.4 60.4 1.0
HE2 A:PHE221 3.5 83.6 1.0
O A:HOH508 3.5 39.0 1.0
N A:ALA237 3.5 58.4 1.0
C A:ILE236 3.5 57.4 1.0
CG2 A:ILE236 3.6 56.0 1.0
H131 A:HLQ400 3.6 85.5 1.0
HZ A:PHE221 3.6 74.6 1.0
N A:PRO238 3.6 58.3 1.0
HG3 A:PRO238 3.8 68.6 1.0
HB2 A:ALA168 3.8 57.2 1.0
HG21 A:ILE236 3.8 68.3 1.0
CD A:PRO238 3.9 58.4 1.0
O A:ALA237 3.9 58.2 1.0
HB A:ILE236 4.0 68.7 1.0
CB A:ALA168 4.0 49.7 1.0
H A:ALA237 4.0 69.6 1.0
CE2 A:PHE221 4.0 68.8 1.0
CZ A:PHE221 4.1 66.5 1.0
C16 A:HLQ400 4.2 65.8 1.0
HA A:PRO238 4.2 68.2 1.0
HG23 A:ILE236 4.2 68.3 1.0
CB A:ILE236 4.2 56.4 1.0
CG A:PRO238 4.3 57.0 1.0
CA A:PRO238 4.5 58.0 1.0
CA A:ILE236 4.5 56.9 1.0
C12 A:HLQ400 4.6 71.0 1.0
HB3 A:ALA168 4.6 57.2 1.0
HD11 A:ILE149 4.6 72.6 1.0
HD2 A:PRO238 4.7 70.0 1.0
HD13 A:ILE149 4.7 72.6 1.0
HA A:ALA168 4.8 64.1 1.0
HB1 A:ALA102 4.8 69.0 1.0
C17 A:HLQ400 4.9 69.6 1.0
HD12 A:ILE149 4.9 72.6 1.0
HB2 A:ALA102 4.9 69.0 1.0
HA A:ILE236 4.9 67.8 1.0
CB A:ALA237 4.9 65.4 1.0
CD1 A:ILE149 5.0 59.6 1.0

Fluorine binding site 4 out of 4 in 6q7w

Go back to Fluorine Binding Sites List in 6q7w
Fluorine binding site 4 out of 4 in the Crystal Structure of Pqsr (Mvfr) Ligand-Binding Domain in Complex with Compound 20


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of Crystal Structure of Pqsr (Mvfr) Ligand-Binding Domain in Complex with Compound 20 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F400

b:60.8
occ:1.00
F22 A:HLQ400 0.0 60.8 1.0
C19 A:HLQ400 1.4 64.6 1.0
F21 A:HLQ400 2.2 65.5 1.0
F20 A:HLQ400 2.2 64.6 1.0
C14 A:HLQ400 2.4 67.2 1.0
HD11 A:ILE149 2.6 72.6 1.0
HZ A:PHE221 2.7 74.6 1.0
N15 A:HLQ400 2.9 66.0 1.0
HD13 A:ILE149 3.0 72.6 1.0
CD1 A:ILE149 3.1 59.6 1.0
HB2 A:ALA102 3.2 69.0 1.0
HD12 A:ILE149 3.3 72.6 1.0
C13 A:HLQ400 3.5 70.4 1.0
CZ A:PHE221 3.5 66.5 1.0
HB1 A:ALA102 3.5 69.0 1.0
HG2 A:PRO129 3.6 84.1 1.0
H131 A:HLQ400 3.7 85.5 1.0
O A:HOH508 3.8 39.0 1.0
HG3 A:PRO238 3.8 68.6 1.0
CB A:ALA102 3.8 56.6 1.0
HE2 A:PHE221 3.9 83.6 1.0
HD3 A:PRO238 4.0 70.0 1.0
C16 A:HLQ400 4.1 65.8 1.0
CE2 A:PHE221 4.1 68.8 1.0
HD21 A:LEU208 4.2 85.5 1.0
HB3 A:ALA102 4.3 69.0 1.0
HD12 A:LEU197 4.3 92.7 1.0
HD22 A:LEU208 4.4 85.5 1.0
CG A:PRO129 4.4 69.2 1.0
HD11 A:LEU197 4.5 92.7 1.0
CG1 A:ILE149 4.5 59.5 1.0
CE1 A:PHE221 4.5 68.3 1.0
HG22 A:ILE236 4.6 68.3 1.0
HE1 A:PHE221 4.6 76.8 1.0
HA A:ALA237 4.6 73.6 1.0
HB2 A:PRO129 4.6 83.8 1.0
C12 A:HLQ400 4.6 71.0 1.0
CG A:PRO238 4.6 57.0 1.0
HG3 A:PRO129 4.6 84.1 1.0
HG12 A:ILE149 4.7 72.4 1.0
CD2 A:LEU208 4.7 70.4 1.0
CD A:PRO238 4.7 58.4 1.0
HB3 A:PRO129 4.7 83.8 1.0
CB A:PRO129 4.8 68.9 1.0
HD23 A:LEU208 4.8 85.5 1.0
HG13 A:ILE149 4.8 72.4 1.0
C17 A:HLQ400 4.9 69.6 1.0
CD1 A:LEU197 4.9 76.4 1.0
HA A:ALA102 4.9 71.5 1.0
HB2 A:ALA168 4.9 57.2 1.0
O A:ILE236 4.9 57.1 1.0
HB1 A:ALA168 5.0 57.2 1.0

Reference:

M.Zender, F.Witzgall, A.F.Kiefer, B.Kirsch, C.K.Maurer, A.M.Kany, N.Xu, S.Schmelz, C.Borger, W.Blankenfeldt, M.Empting. Flexible Fragment Growing Boosts Potency of Quorum Sensing Inhibitors Against Pseudomonas Aeruginosa Virulence. Chemmedchem 2019.
ISSN: ESSN 1860-7187
PubMed: 31709767
DOI: 10.1002/CMDC.201900621
Page generated: Fri Aug 2 00:43:39 2024

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