Fluorine in PDB 6qbs: The Alkyne Moiety As A Latent Electrophile in Irreversible Covalent Small Molecule Inhibitors of Cathepsin K
Enzymatic activity of The Alkyne Moiety As A Latent Electrophile in Irreversible Covalent Small Molecule Inhibitors of Cathepsin K
All present enzymatic activity of The Alkyne Moiety As A Latent Electrophile in Irreversible Covalent Small Molecule Inhibitors of Cathepsin K:
3.4.22.38;
Protein crystallography data
The structure of The Alkyne Moiety As A Latent Electrophile in Irreversible Covalent Small Molecule Inhibitors of Cathepsin K, PDB code: 6qbs
was solved by
E.Mons,
I.D.C.Jansen,
J.Loboda,
B.R.Van Doodewaerd,
M.Verdoes,
C.A.A.Vanboeckel,
P.A.Van Veelen,
B.Turk,
D.Turk,
J.Hermans,
H.Ovaa,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Resolution Low / High (Å)
|
47.09 /
1.70
|
Space group
|
P 61 2 2
|
Cell size a, b, c (Å), α, β, γ (°)
|
75.350,
75.350,
340.200,
90.00,
90.00,
120.00
|
R / Rfree (%)
|
20.4 /
21
|
Other elements in 6qbs:
The structure of The Alkyne Moiety As A Latent Electrophile in Irreversible Covalent Small Molecule Inhibitors of Cathepsin K also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the The Alkyne Moiety As A Latent Electrophile in Irreversible Covalent Small Molecule Inhibitors of Cathepsin K
(pdb code 6qbs). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 6 binding sites of Fluorine where determined in the
The Alkyne Moiety As A Latent Electrophile in Irreversible Covalent Small Molecule Inhibitors of Cathepsin K, PDB code: 6qbs:
Jump to Fluorine binding site number:
1;
2;
3;
4;
5;
6;
Fluorine binding site 1 out
of 6 in 6qbs
Go back to
Fluorine Binding Sites List in 6qbs
Fluorine binding site 1 out
of 6 in the The Alkyne Moiety As A Latent Electrophile in Irreversible Covalent Small Molecule Inhibitors of Cathepsin K
Mono view
Stereo pair view
|
A full contact list of Fluorine with other atoms in the F binding
site number 1 of The Alkyne Moiety As A Latent Electrophile in Irreversible Covalent Small Molecule Inhibitors of Cathepsin K within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:F301
b:19.3
occ:1.00
|
F15
|
A:HVW301
|
0.0
|
19.3
|
1.0
|
C14
|
A:HVW301
|
1.3
|
17.4
|
1.0
|
F16
|
A:HVW301
|
2.1
|
17.6
|
1.0
|
F17
|
A:HVW301
|
2.1
|
21.3
|
1.0
|
C13
|
A:HVW301
|
2.4
|
9.1
|
1.0
|
H43
|
A:HVW301
|
2.4
|
2.0
|
0.0
|
N12
|
A:HVW301
|
2.9
|
8.9
|
1.0
|
H1
|
A:HOH523
|
2.9
|
2.0
|
0.0
|
C18
|
A:HVW301
|
2.9
|
9.7
|
1.0
|
H40
|
A:HVW301
|
3.0
|
2.0
|
0.0
|
O
|
A:HOH523
|
3.2
|
34.2
|
1.0
|
H42
|
A:HVW301
|
3.2
|
2.0
|
0.0
|
C19
|
A:HVW301
|
3.2
|
9.8
|
1.0
|
H1
|
A:HOH722
|
3.3
|
2.0
|
0.0
|
HH
|
A:TYR67
|
3.4
|
2.0
|
0.0
|
H51
|
A:HVW301
|
3.5
|
2.0
|
0.0
|
OH
|
A:TYR67
|
3.7
|
26.4
|
1.0
|
H44
|
A:HVW301
|
3.8
|
2.0
|
0.0
|
O
|
A:HOH722
|
3.9
|
56.6
|
1.0
|
H47
|
A:HVW301
|
3.9
|
2.0
|
0.0
|
C22
|
A:HVW301
|
3.9
|
20.4
|
1.0
|
C7
|
A:HVW301
|
3.9
|
11.2
|
1.0
|
CZ
|
A:TYR67
|
4.0
|
21.0
|
1.0
|
H2
|
A:HOH722
|
4.1
|
2.0
|
0.0
|
H2
|
A:HOH523
|
4.1
|
2.0
|
0.0
|
H1
|
A:HOH573
|
4.1
|
2.0
|
0.0
|
CE1
|
A:TYR67
|
4.1
|
13.6
|
1.0
|
H1
|
B:HOH726
|
4.2
|
2.0
|
0.0
|
H39
|
A:HVW301
|
4.2
|
2.0
|
0.0
|
C11
|
A:HVW301
|
4.2
|
10.6
|
1.0
|
O
|
A:LEU160
|
4.3
|
14.2
|
1.0
|
O
|
A:HOH573
|
4.3
|
24.6
|
1.0
|
C20
|
A:HVW301
|
4.3
|
13.3
|
1.0
|
H53
|
A:HVW301
|
4.4
|
2.0
|
0.0
|
C9
|
A:HVW301
|
4.5
|
13.2
|
1.0
|
H2
|
A:HOH725
|
4.7
|
2.0
|
0.0
|
H2
|
B:HOH726
|
4.8
|
2.0
|
0.0
|
C8
|
A:HVW301
|
4.8
|
9.1
|
1.0
|
H41
|
A:HVW301
|
4.9
|
2.0
|
0.0
|
C23
|
A:HVW301
|
4.9
|
14.0
|
1.0
|
CE2
|
A:TYR67
|
4.9
|
11.5
|
1.0
|
H2
|
A:HOH573
|
4.9
|
2.0
|
0.0
|
O
|
B:HOH726
|
4.9
|
42.5
|
1.0
|
|
Fluorine binding site 2 out
of 6 in 6qbs
Go back to
Fluorine Binding Sites List in 6qbs
Fluorine binding site 2 out
of 6 in the The Alkyne Moiety As A Latent Electrophile in Irreversible Covalent Small Molecule Inhibitors of Cathepsin K
Mono view
Stereo pair view
|
A full contact list of Fluorine with other atoms in the F binding
site number 2 of The Alkyne Moiety As A Latent Electrophile in Irreversible Covalent Small Molecule Inhibitors of Cathepsin K within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:F301
b:17.6
occ:1.00
|
F16
|
A:HVW301
|
0.0
|
17.6
|
1.0
|
C14
|
A:HVW301
|
1.3
|
17.4
|
1.0
|
F15
|
A:HVW301
|
2.1
|
19.3
|
1.0
|
F17
|
A:HVW301
|
2.1
|
21.3
|
1.0
|
C13
|
A:HVW301
|
2.4
|
9.1
|
1.0
|
H44
|
A:HVW301
|
2.5
|
2.0
|
0.0
|
H1
|
A:HOH573
|
2.6
|
2.0
|
0.0
|
H42
|
A:HVW301
|
2.6
|
2.0
|
0.0
|
H51
|
A:HVW301
|
2.8
|
2.0
|
0.0
|
H43
|
A:HVW301
|
2.8
|
2.0
|
0.0
|
N12
|
A:HVW301
|
2.8
|
8.9
|
1.0
|
H1
|
A:HOH523
|
3.0
|
2.0
|
0.0
|
C7
|
A:HVW301
|
3.1
|
11.2
|
1.0
|
O
|
A:HOH573
|
3.1
|
24.6
|
1.0
|
O
|
A:LEU160
|
3.3
|
14.2
|
1.0
|
CA
|
A:ASN161
|
3.6
|
9.8
|
1.0
|
C18
|
A:HVW301
|
3.7
|
9.7
|
1.0
|
C11
|
A:HVW301
|
3.7
|
10.6
|
1.0
|
H2
|
A:HOH721
|
3.7
|
2.0
|
0.0
|
O
|
A:HOH523
|
3.8
|
34.2
|
1.0
|
H1
|
A:HOH722
|
3.8
|
2.0
|
0.0
|
O
|
A:HOH422
|
3.8
|
25.1
|
1.0
|
H2
|
A:HOH573
|
3.8
|
2.0
|
0.0
|
O
|
A:HOH721
|
3.8
|
35.5
|
1.0
|
H1
|
A:HOH422
|
3.9
|
2.0
|
0.0
|
H47
|
A:HVW301
|
4.1
|
2.0
|
0.0
|
O
|
A:ASN161
|
4.1
|
10.3
|
1.0
|
H54
|
A:HVW301
|
4.1
|
2.0
|
0.0
|
C
|
A:ASN161
|
4.1
|
10.8
|
1.0
|
C
|
A:LEU160
|
4.2
|
11.6
|
1.0
|
C5
|
A:HVW301
|
4.2
|
10.2
|
1.0
|
C8
|
A:HVW301
|
4.2
|
9.1
|
1.0
|
H53
|
A:HVW301
|
4.2
|
2.0
|
0.0
|
H2
|
A:HOH422
|
4.2
|
2.0
|
0.0
|
H52
|
A:HVW301
|
4.2
|
2.0
|
0.0
|
C9
|
A:HVW301
|
4.2
|
13.2
|
1.0
|
CB
|
A:ASN161
|
4.3
|
13.2
|
1.0
|
N
|
A:ASN161
|
4.3
|
9.8
|
1.0
|
H39
|
A:HVW301
|
4.4
|
2.0
|
0.0
|
H1
|
A:HOH721
|
4.4
|
2.0
|
0.0
|
H40
|
A:HVW301
|
4.4
|
2.0
|
0.0
|
N4
|
A:HVW301
|
4.5
|
11.0
|
1.0
|
C22
|
A:HVW301
|
4.5
|
20.4
|
1.0
|
C19
|
A:HVW301
|
4.5
|
9.8
|
1.0
|
H2
|
A:HOH523
|
4.5
|
2.0
|
0.0
|
H46
|
A:HVW301
|
4.6
|
2.0
|
0.0
|
O
|
A:HOH722
|
4.7
|
56.6
|
1.0
|
O
|
A:HOH600
|
4.8
|
28.6
|
1.0
|
H45
|
A:HVW301
|
4.9
|
2.0
|
0.0
|
H2
|
A:HOH722
|
5.0
|
2.0
|
0.0
|
|
Fluorine binding site 3 out
of 6 in 6qbs
Go back to
Fluorine Binding Sites List in 6qbs
Fluorine binding site 3 out
of 6 in the The Alkyne Moiety As A Latent Electrophile in Irreversible Covalent Small Molecule Inhibitors of Cathepsin K
Mono view
Stereo pair view
|
A full contact list of Fluorine with other atoms in the F binding
site number 3 of The Alkyne Moiety As A Latent Electrophile in Irreversible Covalent Small Molecule Inhibitors of Cathepsin K within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:F301
b:21.3
occ:1.00
|
F17
|
A:HVW301
|
0.0
|
21.3
|
1.0
|
C14
|
A:HVW301
|
1.3
|
17.4
|
1.0
|
F15
|
A:HVW301
|
2.1
|
19.3
|
1.0
|
F16
|
A:HVW301
|
2.1
|
17.6
|
1.0
|
C13
|
A:HVW301
|
2.3
|
9.1
|
1.0
|
H42
|
A:HVW301
|
2.6
|
2.0
|
0.0
|
H1
|
A:HOH722
|
2.6
|
2.0
|
0.0
|
C18
|
A:HVW301
|
2.8
|
9.7
|
1.0
|
H39
|
A:HVW301
|
2.9
|
2.0
|
0.0
|
C22
|
A:HVW301
|
3.1
|
20.4
|
1.0
|
H2
|
A:HOH725
|
3.2
|
2.0
|
0.0
|
O
|
A:HOH722
|
3.3
|
56.6
|
1.0
|
H1
|
A:HOH573
|
3.3
|
2.0
|
0.0
|
O
|
A:HOH573
|
3.6
|
24.6
|
1.0
|
N12
|
A:HVW301
|
3.6
|
8.9
|
1.0
|
H1
|
A:HOH725
|
3.7
|
2.0
|
0.0
|
H43
|
A:HVW301
|
3.7
|
2.0
|
0.0
|
O
|
A:HOH721
|
3.7
|
35.5
|
1.0
|
O
|
A:HOH725
|
3.8
|
46.7
|
1.0
|
C19
|
A:HVW301
|
3.8
|
9.8
|
1.0
|
H2
|
A:HOH573
|
3.9
|
2.0
|
0.0
|
H1
|
A:HOH721
|
3.9
|
2.0
|
0.0
|
H1
|
A:HOH523
|
3.9
|
2.0
|
0.0
|
H2
|
A:HOH722
|
3.9
|
2.0
|
0.0
|
H2
|
A:HOH721
|
4.0
|
2.0
|
0.0
|
H44
|
A:HVW301
|
4.1
|
2.0
|
0.0
|
H40
|
A:HVW301
|
4.1
|
2.0
|
0.0
|
C23
|
A:HVW301
|
4.2
|
14.0
|
1.0
|
H1
|
A:HOH422
|
4.3
|
2.0
|
0.0
|
O
|
A:HOH600
|
4.3
|
28.6
|
1.0
|
H1
|
A:HOH600
|
4.4
|
2.0
|
0.0
|
C7
|
A:HVW301
|
4.4
|
11.2
|
1.0
|
O
|
A:HOH523
|
4.5
|
34.2
|
1.0
|
O
|
A:HOH422
|
4.6
|
25.1
|
1.0
|
H51
|
A:HVW301
|
4.7
|
2.0
|
0.0
|
H38
|
A:HVW301
|
4.7
|
2.0
|
0.0
|
C20
|
A:HVW301
|
4.8
|
13.3
|
1.0
|
H1
|
B:HOH885
|
4.9
|
2.0
|
0.0
|
O
|
A:LEU160
|
4.9
|
14.2
|
1.0
|
C21
|
A:HVW301
|
5.0
|
10.3
|
1.0
|
|
Fluorine binding site 4 out
of 6 in 6qbs
Go back to
Fluorine Binding Sites List in 6qbs
Fluorine binding site 4 out
of 6 in the The Alkyne Moiety As A Latent Electrophile in Irreversible Covalent Small Molecule Inhibitors of Cathepsin K
Mono view
Stereo pair view
|
A full contact list of Fluorine with other atoms in the F binding
site number 4 of The Alkyne Moiety As A Latent Electrophile in Irreversible Covalent Small Molecule Inhibitors of Cathepsin K within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:F501
b:17.0
occ:1.00
|
F15
|
B:HVW501
|
0.0
|
17.0
|
1.0
|
C14
|
B:HVW501
|
1.4
|
14.3
|
1.0
|
F16
|
B:HVW501
|
2.1
|
15.8
|
1.0
|
F17
|
B:HVW501
|
2.2
|
12.6
|
1.0
|
C13
|
B:HVW501
|
2.4
|
11.9
|
1.0
|
H42
|
B:HVW501
|
2.6
|
2.0
|
0.0
|
C18
|
B:HVW501
|
2.8
|
9.9
|
1.0
|
H40
|
B:HVW501
|
3.2
|
2.0
|
0.0
|
C19
|
B:HVW501
|
3.3
|
11.9
|
1.0
|
N12
|
B:HVW501
|
3.7
|
11.2
|
1.0
|
H43
|
B:HVW501
|
3.7
|
2.0
|
0.0
|
C22
|
B:HVW501
|
3.7
|
9.1
|
1.0
|
H1
|
B:HOH742
|
3.8
|
2.0
|
0.0
|
H39
|
B:HVW501
|
4.0
|
2.0
|
0.0
|
H2
|
B:HOH915
|
4.0
|
2.0
|
0.0
|
O
|
B:HOH915
|
4.0
|
26.0
|
1.0
|
H1
|
B:HOH915
|
4.0
|
2.0
|
0.0
|
H44
|
B:HVW501
|
4.1
|
2.0
|
0.0
|
O
|
B:HOH742
|
4.3
|
27.8
|
1.0
|
C20
|
B:HVW501
|
4.4
|
16.2
|
1.0
|
C7
|
B:HVW501
|
4.4
|
10.7
|
1.0
|
H51
|
B:HVW501
|
4.6
|
2.0
|
0.0
|
C23
|
B:HVW501
|
4.7
|
18.2
|
1.0
|
O
|
B:HOH885
|
4.8
|
54.8
|
1.0
|
H41
|
B:HVW501
|
4.9
|
2.0
|
0.0
|
|
Fluorine binding site 5 out
of 6 in 6qbs
Go back to
Fluorine Binding Sites List in 6qbs
Fluorine binding site 5 out
of 6 in the The Alkyne Moiety As A Latent Electrophile in Irreversible Covalent Small Molecule Inhibitors of Cathepsin K
Mono view
Stereo pair view
|
A full contact list of Fluorine with other atoms in the F binding
site number 5 of The Alkyne Moiety As A Latent Electrophile in Irreversible Covalent Small Molecule Inhibitors of Cathepsin K within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:F501
b:15.8
occ:1.00
|
F16
|
B:HVW501
|
0.0
|
15.8
|
1.0
|
C14
|
B:HVW501
|
1.3
|
14.3
|
1.0
|
F15
|
B:HVW501
|
2.1
|
17.0
|
1.0
|
F17
|
B:HVW501
|
2.1
|
12.6
|
1.0
|
H43
|
B:HVW501
|
2.4
|
2.0
|
0.0
|
C13
|
B:HVW501
|
2.4
|
11.9
|
1.0
|
H39
|
B:HVW501
|
2.8
|
2.0
|
0.0
|
N12
|
B:HVW501
|
2.9
|
11.2
|
1.0
|
C18
|
B:HVW501
|
2.9
|
9.9
|
1.0
|
C22
|
B:HVW501
|
3.1
|
9.1
|
1.0
|
H42
|
B:HVW501
|
3.2
|
2.0
|
0.0
|
H51
|
B:HVW501
|
3.3
|
2.0
|
0.0
|
H2
|
B:HOH780
|
3.3
|
2.0
|
0.0
|
HH
|
B:TYR282
|
3.6
|
2.0
|
0.0
|
OH
|
B:TYR282
|
3.7
|
23.6
|
1.0
|
H44
|
B:HVW501
|
3.7
|
2.0
|
0.0
|
O
|
B:HOH780
|
3.8
|
40.8
|
1.0
|
C7
|
B:HVW501
|
3.9
|
10.7
|
1.0
|
H47
|
B:HVW501
|
3.9
|
2.0
|
0.0
|
C19
|
B:HVW501
|
4.0
|
11.9
|
1.0
|
H1
|
B:HOH780
|
4.1
|
2.0
|
0.0
|
C11
|
B:HVW501
|
4.1
|
8.8
|
1.0
|
H2
|
B:HOH831
|
4.2
|
2.0
|
0.0
|
O
|
B:HOH915
|
4.2
|
26.0
|
1.0
|
CZ
|
B:TYR282
|
4.2
|
15.6
|
1.0
|
C23
|
B:HVW501
|
4.3
|
18.2
|
1.0
|
O
|
B:LEU375
|
4.3
|
25.7
|
1.0
|
H40
|
B:HVW501
|
4.4
|
2.0
|
0.0
|
H1
|
B:HOH915
|
4.4
|
2.0
|
0.0
|
H53
|
B:HVW501
|
4.4
|
2.0
|
0.0
|
O
|
B:HOH885
|
4.4
|
54.8
|
1.0
|
C9
|
B:HVW501
|
4.5
|
8.9
|
1.0
|
H2
|
B:HOH885
|
4.5
|
2.0
|
0.0
|
CE1
|
B:TYR282
|
4.5
|
16.1
|
1.0
|
H2
|
B:HOH915
|
4.6
|
2.0
|
0.0
|
H38
|
B:HVW501
|
4.7
|
2.0
|
0.0
|
C8
|
B:HVW501
|
4.8
|
8.2
|
1.0
|
H52
|
B:HVW501
|
4.9
|
2.0
|
0.0
|
C20
|
B:HVW501
|
5.0
|
16.2
|
1.0
|
|
Fluorine binding site 6 out
of 6 in 6qbs
Go back to
Fluorine Binding Sites List in 6qbs
Fluorine binding site 6 out
of 6 in the The Alkyne Moiety As A Latent Electrophile in Irreversible Covalent Small Molecule Inhibitors of Cathepsin K
Mono view
Stereo pair view
|
A full contact list of Fluorine with other atoms in the F binding
site number 6 of The Alkyne Moiety As A Latent Electrophile in Irreversible Covalent Small Molecule Inhibitors of Cathepsin K within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:F501
b:12.6
occ:1.00
|
F17
|
B:HVW501
|
0.0
|
12.6
|
1.0
|
C14
|
B:HVW501
|
1.3
|
14.3
|
1.0
|
F16
|
B:HVW501
|
2.1
|
15.8
|
1.0
|
F15
|
B:HVW501
|
2.2
|
17.0
|
1.0
|
C13
|
B:HVW501
|
2.3
|
11.9
|
1.0
|
H44
|
B:HVW501
|
2.4
|
2.0
|
0.0
|
H42
|
B:HVW501
|
2.6
|
2.0
|
0.0
|
H43
|
B:HVW501
|
2.7
|
2.0
|
0.0
|
H51
|
B:HVW501
|
2.8
|
2.0
|
0.0
|
N12
|
B:HVW501
|
2.8
|
11.2
|
1.0
|
C7
|
B:HVW501
|
3.1
|
10.7
|
1.0
|
H1
|
B:HOH742
|
3.1
|
2.0
|
0.0
|
CA
|
B:ASN376
|
3.4
|
18.1
|
1.0
|
O
|
B:LEU375
|
3.5
|
25.7
|
1.0
|
O
|
B:HOH742
|
3.6
|
27.8
|
1.0
|
C18
|
B:HVW501
|
3.7
|
9.9
|
1.0
|
C11
|
B:HVW501
|
3.7
|
8.8
|
1.0
|
O
|
B:ASN376
|
3.8
|
14.7
|
1.0
|
C
|
B:ASN376
|
3.9
|
13.6
|
1.0
|
C5
|
B:HVW501
|
4.0
|
9.8
|
1.0
|
CB
|
B:ASN376
|
4.0
|
16.6
|
1.0
|
H52
|
B:HVW501
|
4.0
|
2.0
|
0.0
|
H54
|
B:HVW501
|
4.1
|
2.0
|
0.0
|
C8
|
B:HVW501
|
4.2
|
8.2
|
1.0
|
H47
|
B:HVW501
|
4.2
|
2.0
|
0.0
|
C9
|
B:HVW501
|
4.3
|
8.9
|
1.0
|
H39
|
B:HVW501
|
4.3
|
2.0
|
0.0
|
H53
|
B:HVW501
|
4.3
|
2.0
|
0.0
|
C
|
B:LEU375
|
4.3
|
16.6
|
1.0
|
N4
|
B:HVW501
|
4.3
|
11.9
|
1.0
|
N
|
B:ASN376
|
4.3
|
14.0
|
1.0
|
H2
|
B:HOH742
|
4.4
|
2.0
|
0.0
|
C22
|
B:HVW501
|
4.4
|
9.1
|
1.0
|
H40
|
B:HVW501
|
4.5
|
2.0
|
0.0
|
C19
|
B:HVW501
|
4.6
|
11.9
|
1.0
|
H46
|
B:HVW501
|
4.6
|
2.0
|
0.0
|
O6
|
B:HVW501
|
4.9
|
10.3
|
1.0
|
H2
|
B:HOH780
|
4.9
|
2.0
|
0.0
|
H45
|
B:HVW501
|
4.9
|
2.0
|
0.0
|
O
|
B:HOH780
|
5.0
|
40.8
|
1.0
|
N
|
B:HIS377
|
5.0
|
13.0
|
1.0
|
|
Reference:
E.Mons,
I.D.C.Jansen,
J.Loboda,
B.R.Van Doodewaerd,
J.Hermans,
M.Verdoes,
C.A.A.Van Boeckel,
P.A.Van Veelen,
B.Turk,
D.Turk,
H.Ovaa.
The Alkyne Moiety As A Latent Electrophile in Irreversible Covalent Small Molecule Inhibitors of Cathepsin K. J. Am. Chem. Soc. V. 141 3507 2019.
ISSN: ESSN 1520-5126
PubMed: 30689386
DOI: 10.1021/JACS.8B11027
Page generated: Fri Aug 2 00:46:27 2024
|