|
Atomistry » Fluorine » PDB 6q0t-6qhv » 6qei | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 6q0t-6qhv » 6qei » |
Fluorine in PDB 6qei: Crystal Structure of Human Methionine Aminopeptidase-2 in Complex with An Inhibitor 5,6-Difluoro-3-(2-Isopropoxy-4-Piperazin-1-Yl-Phenyl)- 1H-Indole-2-Carboxylic Acid AmideEnzymatic activity of Crystal Structure of Human Methionine Aminopeptidase-2 in Complex with An Inhibitor 5,6-Difluoro-3-(2-Isopropoxy-4-Piperazin-1-Yl-Phenyl)- 1H-Indole-2-Carboxylic Acid Amide
All present enzymatic activity of Crystal Structure of Human Methionine Aminopeptidase-2 in Complex with An Inhibitor 5,6-Difluoro-3-(2-Isopropoxy-4-Piperazin-1-Yl-Phenyl)- 1H-Indole-2-Carboxylic Acid Amide:
3.4.11.18; Protein crystallography data
The structure of Crystal Structure of Human Methionine Aminopeptidase-2 in Complex with An Inhibitor 5,6-Difluoro-3-(2-Isopropoxy-4-Piperazin-1-Yl-Phenyl)- 1H-Indole-2-Carboxylic Acid Amide, PDB code: 6qei
was solved by
D.Musil,
T.Heinrich,
M.Lehmann,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 6qei:
The structure of Crystal Structure of Human Methionine Aminopeptidase-2 in Complex with An Inhibitor 5,6-Difluoro-3-(2-Isopropoxy-4-Piperazin-1-Yl-Phenyl)- 1H-Indole-2-Carboxylic Acid Amide also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of Human Methionine Aminopeptidase-2 in Complex with An Inhibitor 5,6-Difluoro-3-(2-Isopropoxy-4-Piperazin-1-Yl-Phenyl)- 1H-Indole-2-Carboxylic Acid Amide
(pdb code 6qei). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Crystal Structure of Human Methionine Aminopeptidase-2 in Complex with An Inhibitor 5,6-Difluoro-3-(2-Isopropoxy-4-Piperazin-1-Yl-Phenyl)- 1H-Indole-2-Carboxylic Acid Amide, PDB code: 6qei: Jump to Fluorine binding site number: 1; 2; Fluorine binding site 1 out of 2 in 6qeiGo back to Fluorine Binding Sites List in 6qei
Fluorine binding site 1 out
of 2 in the Crystal Structure of Human Methionine Aminopeptidase-2 in Complex with An Inhibitor 5,6-Difluoro-3-(2-Isopropoxy-4-Piperazin-1-Yl-Phenyl)- 1H-Indole-2-Carboxylic Acid Amide
Mono view Stereo pair view
Fluorine binding site 2 out of 2 in 6qeiGo back to Fluorine Binding Sites List in 6qei
Fluorine binding site 2 out
of 2 in the Crystal Structure of Human Methionine Aminopeptidase-2 in Complex with An Inhibitor 5,6-Difluoro-3-(2-Isopropoxy-4-Piperazin-1-Yl-Phenyl)- 1H-Indole-2-Carboxylic Acid Amide
Mono view Stereo pair view
Reference:
T.Heinrich,
J.Seenisamy,
B.Blume,
J.Bomke,
M.Calderini,
U.Eckert,
M.Friese-Hamim,
R.Kohl,
M.Lehmann,
B.Leuthner,
D.Musil,
F.Rohdich,
F.T.Zenke.
Discovery and Structure-Based Optimization of Next-Generation Reversible Methionine Aminopeptidase-2 (Metap-2) Inhibitors. J.Med.Chem. V. 62 5025 2019.
Page generated: Fri Aug 2 00:48:21 2024
ISSN: ISSN 0022-2623 PubMed: 30939017 DOI: 10.1021/ACS.JMEDCHEM.9B00041 |
Last articlesW in 8QLNW in 8RJA V in 8WTN Te in 8QLN Re in 9GHX Rb in 8Z5C Ni in 9C0T Ni in 9C0S Ni in 9GP1 Ni in 9FYO |
© Copyright 2008-2020 by atomistry.com | ||
Home | Site Map | Copyright | Contact us | Privacy |