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Atomistry » Fluorine » PDB 6rkp-6rzg » 6rln | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 6rkp-6rzg » 6rln » |
Fluorine in PDB 6rln: Crystal Structure of RIP1 Kinase in Complex with GSK3145095Enzymatic activity of Crystal Structure of RIP1 Kinase in Complex with GSK3145095
All present enzymatic activity of Crystal Structure of RIP1 Kinase in Complex with GSK3145095:
2.7.11.1; Protein crystallography data
The structure of Crystal Structure of RIP1 Kinase in Complex with GSK3145095, PDB code: 6rln
was solved by
J.H.Thorpe,
P.A.Harris,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of RIP1 Kinase in Complex with GSK3145095
(pdb code 6rln). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 4 binding sites of Fluorine where determined in the Crystal Structure of RIP1 Kinase in Complex with GSK3145095, PDB code: 6rln: Jump to Fluorine binding site number: 1; 2; 3; 4; Fluorine binding site 1 out of 4 in 6rlnGo back to Fluorine Binding Sites List in 6rln
Fluorine binding site 1 out
of 4 in the Crystal Structure of RIP1 Kinase in Complex with GSK3145095
Mono view Stereo pair view
Fluorine binding site 2 out of 4 in 6rlnGo back to Fluorine Binding Sites List in 6rln
Fluorine binding site 2 out
of 4 in the Crystal Structure of RIP1 Kinase in Complex with GSK3145095
Mono view Stereo pair view
Fluorine binding site 3 out of 4 in 6rlnGo back to Fluorine Binding Sites List in 6rln
Fluorine binding site 3 out
of 4 in the Crystal Structure of RIP1 Kinase in Complex with GSK3145095
Mono view Stereo pair view
Fluorine binding site 4 out of 4 in 6rlnGo back to Fluorine Binding Sites List in 6rln
Fluorine binding site 4 out
of 4 in the Crystal Structure of RIP1 Kinase in Complex with GSK3145095
Mono view Stereo pair view
Reference:
P.A.Harris,
J.M.Marinis,
J.D.Lich,
S.B.Berger,
A.Chirala,
J.A.Cox,
P.M.Eidam,
J.N.Finger,
P.J.Gough,
J.U.Jeong,
J.Kang,
V.Kasparcova,
L.K.Leister,
M.K.Mahajan,
G.Miller,
R.Nagilla,
M.T.Ouellette,
M.A.Reilly,
A.R.Rendina,
E.J.Rivera,
H.H.Sun,
J.H.Thorpe,
R.D.Totoritis,
W.Wang,
D.Wu,
D.Zhang,
J.Bertin,
R.W.Marquis.
Identification of A RIP1 Kinase Inhibitor Clinical Candidate (GSK3145095) For the Treatment of Pancreatic Cancer. Acs Med.Chem.Lett. V. 10 857 2019.
Page generated: Fri Aug 2 01:17:30 2024
ISSN: ISSN 1948-5875 PubMed: 31223438 DOI: 10.1021/ACSMEDCHEMLETT.9B00108 |
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