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Fluorine in PDB 6rsz: Human Carbonic Anhydrase II in Complex with Fluorinated Benzenesulfonamide
Enzymatic activity of Human Carbonic Anhydrase II in Complex with Fluorinated Benzenesulfonamide
All present enzymatic activity of Human Carbonic Anhydrase II in Complex with Fluorinated Benzenesulfonamide:
4.2.1.1;
4.2.1.1;
Protein crystallography data
The structure of Human Carbonic Anhydrase II in Complex with Fluorinated Benzenesulfonamide, PDB code: 6rsz
was solved by
S.Gloeckner,
K.Ngo,
A.Heine,
G.Klebe,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 23.27 / 1.09 |
| Space group | P 1 21 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 42.166, 41.445, 72.097, 90.00, 104.48, 90.00 |
| R / Rfree (%) | 12.3 / 12.9 |
Other elements in 6rsz:
The structure of Human Carbonic Anhydrase II in Complex with Fluorinated Benzenesulfonamide also contains other interesting chemical elements:
| Mercury | (Hg) | 2 atoms |
| Zinc | (Zn) | 1 atom |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Human Carbonic Anhydrase II in Complex with Fluorinated Benzenesulfonamide
(pdb code 6rsz). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 4 binding sites of Fluorine where determined in the Human Carbonic Anhydrase II in Complex with Fluorinated Benzenesulfonamide, PDB code: 6rsz:
Jump to Fluorine binding site number: 1; 2; 3; 4;
In total 4 binding sites of Fluorine where determined in the Human Carbonic Anhydrase II in Complex with Fluorinated Benzenesulfonamide, PDB code: 6rsz:
Jump to Fluorine binding site number: 1; 2; 3; 4;
Fluorine binding site 1 out of 4 in 6rsz
Go back to
Fluorine Binding Sites List in 6rsz
Fluorine binding site 1 out
of 4 in the Human Carbonic Anhydrase II in Complex with Fluorinated Benzenesulfonamide
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Human Carbonic Anhydrase II in Complex with Fluorinated Benzenesulfonamide within 5.0Å range:
|
Fluorine binding site 2 out of 4 in 6rsz
Go back to
Fluorine Binding Sites List in 6rsz
Fluorine binding site 2 out
of 4 in the Human Carbonic Anhydrase II in Complex with Fluorinated Benzenesulfonamide
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Human Carbonic Anhydrase II in Complex with Fluorinated Benzenesulfonamide within 5.0Å range:
|
Fluorine binding site 3 out of 4 in 6rsz
Go back to
Fluorine Binding Sites List in 6rsz
Fluorine binding site 3 out
of 4 in the Human Carbonic Anhydrase II in Complex with Fluorinated Benzenesulfonamide
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Human Carbonic Anhydrase II in Complex with Fluorinated Benzenesulfonamide within 5.0Å range:
|
Fluorine binding site 4 out of 4 in 6rsz
Go back to
Fluorine Binding Sites List in 6rsz
Fluorine binding site 4 out
of 4 in the Human Carbonic Anhydrase II in Complex with Fluorinated Benzenesulfonamide
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 4 of Human Carbonic Anhydrase II in Complex with Fluorinated Benzenesulfonamide within 5.0Å range:
|
Reference:
S.Glockner,
K.Ngo,
B.Wagner,
A.Heine,
G.Klebe.
The Influence of Varying Fluorination Patterns on the Thermodynamics and Kinetics of Benzenesulfonamide Binding to Human Carbonic Anhydrase II. Biomolecules V. 10 2020.
ISSN: ESSN 2218-273X
PubMed: 32230853
DOI: 10.3390/BIOM10040509
Page generated: Fri Aug 2 01:24:02 2024
ISSN: ESSN 2218-273X
PubMed: 32230853
DOI: 10.3390/BIOM10040509
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