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Fluorine in PDB 6rv4: Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 2341237
Protein crystallography data
The structure of Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 2341237, PDB code: 6rv4
was solved by
K.E.J.Rodstrom,
A.C.W.Pike,
W.Zhang,
A.Quigley,
D.Speedman,
S.M.M.Mukhopadhyay,
L.Shrestha,
R.Chalk,
S.Venkaya,
S.R.Bushell,
A.Tessitore,
N.Burgess-Brown,
C.H.Arrowsmith,
A.M.Edwards,
C.Bountra,
E.P.Carpenter,
Structural Genomics Consortium (Sgc),
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 41.16 / 3.10 |
| Space group | P 2 21 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 45.100, 201.330, 238.570, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 25 / 25.6 |
Other elements in 6rv4:
The structure of Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 2341237 also contains other interesting chemical elements:
| Potassium | (K) | 8 atoms |
| Chlorine | (Cl) | 2 atoms |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 2341237
(pdb code 6rv4). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 6 binding sites of Fluorine where determined in the Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 2341237, PDB code: 6rv4:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6;
In total 6 binding sites of Fluorine where determined in the Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 2341237, PDB code: 6rv4:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6;
Fluorine binding site 1 out of 6 in 6rv4
Go back to
Fluorine Binding Sites List in 6rv4
Fluorine binding site 1 out
of 6 in the Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 2341237
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 2341237 within 5.0Å range:
|
Fluorine binding site 2 out of 6 in 6rv4
Go back to
Fluorine Binding Sites List in 6rv4
Fluorine binding site 2 out
of 6 in the Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 2341237
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 2341237 within 5.0Å range:
|
Fluorine binding site 3 out of 6 in 6rv4
Go back to
Fluorine Binding Sites List in 6rv4
Fluorine binding site 3 out
of 6 in the Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 2341237
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 2341237 within 5.0Å range:
|
Fluorine binding site 4 out of 6 in 6rv4
Go back to
Fluorine Binding Sites List in 6rv4
Fluorine binding site 4 out
of 6 in the Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 2341237
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 4 of Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 2341237 within 5.0Å range:
|
Fluorine binding site 5 out of 6 in 6rv4
Go back to
Fluorine Binding Sites List in 6rv4
Fluorine binding site 5 out
of 6 in the Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 2341237
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 5 of Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 2341237 within 5.0Å range:
|
Fluorine binding site 6 out of 6 in 6rv4
Go back to
Fluorine Binding Sites List in 6rv4
Fluorine binding site 6 out
of 6 in the Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 2341237
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 6 of Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 2341237 within 5.0Å range:
|
Reference:
K.E.J.Rodstrom,
A.K.Kiper,
W.Zhang,
S.Rinne,
A.C.W.Pike,
M.Goldstein,
L.Conrad,
M.Delbeck,
M.Hahn,
H.Meier,
M.Platzk,
A.Quigley,
D.Speedman,
L.Shrestha,
S.M.M.Mukhopadhyay,
N.A.Burgess-Brown,
S.J.Tucker,
T.Mueller,
N.Decher,
E.P.Carpenter.
A Unique Lower X-Gate in Task Channels Sequesters Inhibitors Within the Vestibule To Be Published.
Page generated: Fri Aug 2 01:25:28 2024
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