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Atomistry » Fluorine » PDB 6taw-6tuf » 6td5 » |
Fluorine in PDB 6td5: Leishmania Tarentolae Proteasome 20S Subunit Complexed with LXE408 and BortezomibEnzymatic activity of Leishmania Tarentolae Proteasome 20S Subunit Complexed with LXE408 and Bortezomib
All present enzymatic activity of Leishmania Tarentolae Proteasome 20S Subunit Complexed with LXE408 and Bortezomib:
3.4.25.1; Fluorine Binding Sites:
The binding sites of Fluorine atom in the Leishmania Tarentolae Proteasome 20S Subunit Complexed with LXE408 and Bortezomib
(pdb code 6td5). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Leishmania Tarentolae Proteasome 20S Subunit Complexed with LXE408 and Bortezomib, PDB code: 6td5: Jump to Fluorine binding site number: 1; 2; Fluorine binding site 1 out of 2 in 6td5Go back to Fluorine Binding Sites List in 6td5
Fluorine binding site 1 out
of 2 in the Leishmania Tarentolae Proteasome 20S Subunit Complexed with LXE408 and Bortezomib
Mono view Stereo pair view
Fluorine binding site 2 out of 2 in 6td5Go back to Fluorine Binding Sites List in 6td5
Fluorine binding site 2 out
of 2 in the Leishmania Tarentolae Proteasome 20S Subunit Complexed with LXE408 and Bortezomib
Mono view Stereo pair view
Reference:
A.Nagle,
A.Biggart,
C.Be,
H.Srinivas,
A.Hein,
D.Caridha,
R.J.Sciotti,
B.Pybus,
M.Kreishman-Deitrick,
B.Bursulaya,
Y.H.Lai,
M.Y.Gao,
F.Liang,
C.J.N.Mathison,
X.Liu,
V.Yeh,
J.Smith,
I.Lerario,
Y.Xie,
D.Chianelli,
M.Gibney,
A.Berman,
Y.L.Chen,
J.Jiricek,
L.C.Davis,
X.Liu,
J.Ballard,
S.Khare,
F.K.Eggimann,
A.Luneau,
T.Groessl,
M.Shapiro,
W.Richmond,
K.Johnson,
P.J.Rudewicz,
S.P.S.Rao,
C.Thompson,
T.Tuntland,
G.Spraggon,
R.J.Glynne,
F.Supek,
C.Wiesmann,
V.Molteni.
Discovery and Characterization of Clinical Candidate LXE408 As A Kinetoplastid-Selective Proteasome Inhibitor For the Treatment of Leishmaniases. J.Med.Chem. V. 63 10773 2020.
Page generated: Fri Aug 2 02:01:39 2024
ISSN: ISSN 0022-2623 PubMed: 32667203 DOI: 10.1021/ACS.JMEDCHEM.0C00499 |
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