Fluorine in PDB 6teq: Crystal Structure of A Galactokinase From Bifidobacterium Infantis in Complex with 2-Deoxy-2-Fluoro-Galactose
Protein crystallography data
The structure of Crystal Structure of A Galactokinase From Bifidobacterium Infantis in Complex with 2-Deoxy-2-Fluoro-Galactose, PDB code: 6teq
was solved by
T.Keenan,
F.Parmeggiani,
C.Q.Fontenelle,
J.Malassis,
J.Vendeville,
W.A.Offen,
P.Both,
K.Huang,
A.Marchesi,
A.Heyam,
C.Young,
S.Charnock,
G.J.Davies,
B.Linclau,
S.L.Flitsch,
M.A.Fascione,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Resolution Low / High (Å)
|
94.55 /
1.44
|
Space group
|
P 1 21 1
|
Cell size a, b, c (Å), α, β, γ (°)
|
52.218,
164.386,
115.874,
90.00,
95.94,
90.00
|
R / Rfree (%)
|
16.9 /
20.3
|
Other elements in 6teq:
The structure of Crystal Structure of A Galactokinase From Bifidobacterium Infantis in Complex with 2-Deoxy-2-Fluoro-Galactose also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of A Galactokinase From Bifidobacterium Infantis in Complex with 2-Deoxy-2-Fluoro-Galactose
(pdb code 6teq). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 8 binding sites of Fluorine where determined in the
Crystal Structure of A Galactokinase From Bifidobacterium Infantis in Complex with 2-Deoxy-2-Fluoro-Galactose, PDB code: 6teq:
Jump to Fluorine binding site number:
1;
2;
3;
4;
5;
6;
7;
8;
Fluorine binding site 1 out
of 8 in 6teq
Go back to
Fluorine Binding Sites List in 6teq
Fluorine binding site 1 out
of 8 in the Crystal Structure of A Galactokinase From Bifidobacterium Infantis in Complex with 2-Deoxy-2-Fluoro-Galactose
Mono view
Stereo pair view
|
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Crystal Structure of A Galactokinase From Bifidobacterium Infantis in Complex with 2-Deoxy-2-Fluoro-Galactose within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:F609
b:15.5
occ:0.60
|
F2
|
A:GAF609
|
0.0
|
15.5
|
0.6
|
F2
|
A:2FG610
|
0.1
|
25.5
|
0.4
|
C2
|
A:2FG610
|
1.3
|
20.5
|
0.4
|
C2
|
A:GAF609
|
1.4
|
14.7
|
0.6
|
O
|
A:HOH709
|
2.3
|
16.3
|
1.0
|
C1
|
A:GAF609
|
2.3
|
14.9
|
0.6
|
C3
|
A:GAF609
|
2.3
|
11.9
|
0.6
|
C3
|
A:2FG610
|
2.4
|
17.7
|
0.4
|
C1
|
A:2FG610
|
2.4
|
20.1
|
0.4
|
O1
|
A:GAF609
|
2.6
|
17.8
|
0.6
|
O1
|
A:2FG610
|
2.8
|
17.0
|
0.4
|
O3
|
A:GAF609
|
2.9
|
14.7
|
0.6
|
O3
|
A:2FG610
|
2.9
|
20.4
|
0.4
|
O
|
A:HOH786
|
2.9
|
24.3
|
1.0
|
OD2
|
A:ASP191
|
3.2
|
15.8
|
1.0
|
OG1
|
A:THR187
|
3.2
|
22.5
|
1.0
|
O
|
A:HOH874
|
3.3
|
16.0
|
1.0
|
O
|
A:HOH902
|
3.5
|
39.4
|
1.0
|
O
|
A:HOH804
|
3.5
|
31.2
|
1.0
|
O5
|
A:GAF609
|
3.6
|
15.6
|
0.6
|
O5
|
A:2FG610
|
3.6
|
20.2
|
0.4
|
C4
|
A:GAF609
|
3.7
|
13.5
|
0.6
|
C4
|
A:2FG610
|
3.7
|
18.8
|
0.4
|
CG
|
A:ASP191
|
3.7
|
13.1
|
1.0
|
OD1
|
A:ASP191
|
4.0
|
13.1
|
1.0
|
CB
|
A:THR187
|
4.1
|
20.1
|
1.0
|
C5
|
A:GAF609
|
4.1
|
12.3
|
0.6
|
C5
|
A:2FG610
|
4.1
|
18.4
|
0.4
|
OH
|
A:TYR248
|
4.3
|
17.3
|
1.0
|
CA
|
A:THR187
|
4.3
|
20.4
|
1.0
|
O4
|
A:2FG610
|
4.4
|
19.2
|
0.4
|
O4
|
A:GAF609
|
4.4
|
14.1
|
0.6
|
N
|
A:GLY188
|
4.5
|
16.3
|
1.0
|
O
|
A:HOH707
|
4.5
|
22.6
|
1.0
|
CZ
|
A:TYR248
|
4.6
|
18.1
|
1.0
|
CE1
|
A:TYR248
|
4.8
|
16.6
|
1.0
|
CB
|
A:ASP191
|
4.9
|
12.9
|
1.0
|
C
|
A:THR187
|
4.9
|
16.8
|
1.0
|
O
|
A:SER186
|
4.9
|
20.5
|
1.0
|
O
|
A:HOH923
|
5.0
|
23.9
|
1.0
|
|
Fluorine binding site 2 out
of 8 in 6teq
Go back to
Fluorine Binding Sites List in 6teq
Fluorine binding site 2 out
of 8 in the Crystal Structure of A Galactokinase From Bifidobacterium Infantis in Complex with 2-Deoxy-2-Fluoro-Galactose
Mono view
Stereo pair view
|
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Crystal Structure of A Galactokinase From Bifidobacterium Infantis in Complex with 2-Deoxy-2-Fluoro-Galactose within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:F610
b:25.5
occ:0.40
|
F2
|
A:2FG610
|
0.0
|
25.5
|
0.4
|
F2
|
A:GAF609
|
0.1
|
15.5
|
0.6
|
C2
|
A:2FG610
|
1.4
|
20.5
|
0.4
|
C2
|
A:GAF609
|
1.4
|
14.7
|
0.6
|
C1
|
A:GAF609
|
2.3
|
14.9
|
0.6
|
O
|
A:HOH709
|
2.3
|
16.3
|
1.0
|
C1
|
A:2FG610
|
2.3
|
20.1
|
0.4
|
C3
|
A:GAF609
|
2.4
|
11.9
|
0.6
|
C3
|
A:2FG610
|
2.4
|
17.7
|
0.4
|
O1
|
A:GAF609
|
2.4
|
17.8
|
0.6
|
O1
|
A:2FG610
|
2.7
|
17.0
|
0.4
|
O
|
A:HOH786
|
2.9
|
24.3
|
1.0
|
O3
|
A:GAF609
|
2.9
|
14.7
|
0.6
|
O3
|
A:2FG610
|
3.0
|
20.4
|
0.4
|
OD2
|
A:ASP191
|
3.1
|
15.8
|
1.0
|
O
|
A:HOH874
|
3.3
|
16.0
|
1.0
|
O
|
A:HOH804
|
3.3
|
31.2
|
1.0
|
OG1
|
A:THR187
|
3.3
|
22.5
|
1.0
|
O
|
A:HOH902
|
3.5
|
39.4
|
1.0
|
O5
|
A:GAF609
|
3.6
|
15.6
|
0.6
|
O5
|
A:2FG610
|
3.6
|
20.2
|
0.4
|
CG
|
A:ASP191
|
3.7
|
13.1
|
1.0
|
C4
|
A:GAF609
|
3.7
|
13.5
|
0.6
|
C4
|
A:2FG610
|
3.8
|
18.8
|
0.4
|
OD1
|
A:ASP191
|
3.9
|
13.1
|
1.0
|
C5
|
A:GAF609
|
4.0
|
12.3
|
0.6
|
C5
|
A:2FG610
|
4.1
|
18.4
|
0.4
|
CB
|
A:THR187
|
4.2
|
20.1
|
1.0
|
OH
|
A:TYR248
|
4.4
|
17.3
|
1.0
|
CA
|
A:THR187
|
4.4
|
20.4
|
1.0
|
O4
|
A:2FG610
|
4.4
|
19.2
|
0.4
|
O4
|
A:GAF609
|
4.4
|
14.1
|
0.6
|
O
|
A:HOH707
|
4.5
|
22.6
|
1.0
|
N
|
A:GLY188
|
4.6
|
16.3
|
1.0
|
CZ
|
A:TYR248
|
4.7
|
18.1
|
1.0
|
CB
|
A:ASP191
|
4.9
|
12.9
|
1.0
|
O
|
A:HOH923
|
4.9
|
23.9
|
1.0
|
CE1
|
A:TYR248
|
4.9
|
16.6
|
1.0
|
NH1
|
A:ARG40
|
4.9
|
14.5
|
1.0
|
O
|
A:HOH702
|
4.9
|
23.2
|
0.5
|
|
Fluorine binding site 3 out
of 8 in 6teq
Go back to
Fluorine Binding Sites List in 6teq
Fluorine binding site 3 out
of 8 in the Crystal Structure of A Galactokinase From Bifidobacterium Infantis in Complex with 2-Deoxy-2-Fluoro-Galactose
Mono view
Stereo pair view
|
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Crystal Structure of A Galactokinase From Bifidobacterium Infantis in Complex with 2-Deoxy-2-Fluoro-Galactose within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:F609
b:26.1
occ:0.60
|
F2
|
B:2FG609
|
0.0
|
26.1
|
0.6
|
F2
|
B:GAF610
|
0.0
|
17.1
|
0.4
|
C2
|
B:GAF610
|
1.4
|
14.0
|
0.4
|
C2
|
B:2FG609
|
1.4
|
22.4
|
0.6
|
C1
|
B:GAF610
|
2.3
|
13.4
|
0.4
|
C1
|
B:2FG609
|
2.3
|
21.9
|
0.6
|
O
|
B:HOH706
|
2.4
|
16.3
|
1.0
|
C3
|
B:GAF610
|
2.5
|
13.6
|
0.4
|
C3
|
B:2FG609
|
2.5
|
20.4
|
0.6
|
O1
|
B:2FG609
|
2.7
|
22.6
|
0.6
|
O1
|
B:GAF610
|
2.7
|
13.5
|
0.4
|
O
|
B:HOH829
|
2.9
|
25.5
|
1.0
|
O
|
B:HOH905
|
2.9
|
36.5
|
1.0
|
O3
|
B:GAF610
|
3.0
|
12.3
|
0.4
|
O3
|
B:2FG609
|
3.0
|
18.8
|
0.6
|
OD2
|
B:ASP191
|
3.1
|
17.0
|
1.0
|
OG1
|
B:THR187
|
3.2
|
23.8
|
1.0
|
O
|
B:HOH739
|
3.4
|
29.8
|
1.0
|
O
|
B:HOH896
|
3.4
|
15.3
|
1.0
|
O5
|
B:GAF610
|
3.5
|
13.1
|
0.4
|
O5
|
B:2FG609
|
3.5
|
23.9
|
0.6
|
C4
|
B:GAF610
|
3.8
|
12.6
|
0.4
|
CG
|
B:ASP191
|
3.8
|
13.1
|
1.0
|
C4
|
B:2FG609
|
3.8
|
19.1
|
0.6
|
OD1
|
B:ASP191
|
3.9
|
13.6
|
1.0
|
C5
|
B:GAF610
|
4.0
|
13.0
|
0.4
|
C5
|
B:2FG609
|
4.1
|
19.4
|
0.6
|
CB
|
B:THR187
|
4.1
|
22.1
|
1.0
|
OH
|
B:TYR248
|
4.2
|
18.2
|
1.0
|
CA
|
B:THR187
|
4.4
|
17.1
|
1.0
|
O4
|
B:GAF610
|
4.4
|
14.3
|
0.4
|
O4
|
B:2FG609
|
4.4
|
22.2
|
0.6
|
O
|
B:HOH774
|
4.5
|
25.1
|
1.0
|
N
|
B:GLY188
|
4.5
|
17.4
|
1.0
|
CZ
|
B:TYR248
|
4.5
|
17.6
|
1.0
|
CE1
|
B:TYR248
|
4.7
|
17.0
|
1.0
|
O
|
B:HOH701
|
4.9
|
20.6
|
0.5
|
O
|
B:HOH881
|
4.9
|
25.0
|
1.0
|
CB
|
B:ASP191
|
4.9
|
14.0
|
1.0
|
NH1
|
B:ARG40
|
5.0
|
15.7
|
1.0
|
|
Fluorine binding site 4 out
of 8 in 6teq
Go back to
Fluorine Binding Sites List in 6teq
Fluorine binding site 4 out
of 8 in the Crystal Structure of A Galactokinase From Bifidobacterium Infantis in Complex with 2-Deoxy-2-Fluoro-Galactose
Mono view
Stereo pair view
|
A full contact list of Fluorine with other atoms in the F binding
site number 4 of Crystal Structure of A Galactokinase From Bifidobacterium Infantis in Complex with 2-Deoxy-2-Fluoro-Galactose within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:F610
b:17.1
occ:0.40
|
F2
|
B:GAF610
|
0.0
|
17.1
|
0.4
|
F2
|
B:2FG609
|
0.0
|
26.1
|
0.6
|
C2
|
B:GAF610
|
1.4
|
14.0
|
0.4
|
C2
|
B:2FG609
|
1.4
|
22.4
|
0.6
|
C1
|
B:GAF610
|
2.3
|
13.4
|
0.4
|
C1
|
B:2FG609
|
2.3
|
21.9
|
0.6
|
O
|
B:HOH706
|
2.4
|
16.3
|
1.0
|
C3
|
B:GAF610
|
2.5
|
13.6
|
0.4
|
C3
|
B:2FG609
|
2.5
|
20.4
|
0.6
|
O1
|
B:2FG609
|
2.7
|
22.6
|
0.6
|
O1
|
B:GAF610
|
2.8
|
13.5
|
0.4
|
O
|
B:HOH829
|
2.9
|
25.5
|
1.0
|
O
|
B:HOH905
|
2.9
|
36.5
|
1.0
|
O3
|
B:GAF610
|
3.0
|
12.3
|
0.4
|
O3
|
B:2FG609
|
3.0
|
18.8
|
0.6
|
OG1
|
B:THR187
|
3.2
|
23.8
|
1.0
|
OD2
|
B:ASP191
|
3.2
|
17.0
|
1.0
|
O
|
B:HOH896
|
3.4
|
15.3
|
1.0
|
O
|
B:HOH739
|
3.4
|
29.8
|
1.0
|
O5
|
B:GAF610
|
3.5
|
13.1
|
0.4
|
O5
|
B:2FG609
|
3.5
|
23.9
|
0.6
|
C4
|
B:GAF610
|
3.8
|
12.6
|
0.4
|
C4
|
B:2FG609
|
3.8
|
19.1
|
0.6
|
CG
|
B:ASP191
|
3.8
|
13.1
|
1.0
|
OD1
|
B:ASP191
|
4.0
|
13.6
|
1.0
|
C5
|
B:GAF610
|
4.1
|
13.0
|
0.4
|
C5
|
B:2FG609
|
4.1
|
19.4
|
0.6
|
CB
|
B:THR187
|
4.1
|
22.1
|
1.0
|
OH
|
B:TYR248
|
4.2
|
18.2
|
1.0
|
CA
|
B:THR187
|
4.3
|
17.1
|
1.0
|
O4
|
B:GAF610
|
4.4
|
14.3
|
0.4
|
O4
|
B:2FG609
|
4.4
|
22.2
|
0.6
|
O
|
B:HOH774
|
4.5
|
25.1
|
1.0
|
N
|
B:GLY188
|
4.5
|
17.4
|
1.0
|
CZ
|
B:TYR248
|
4.5
|
17.6
|
1.0
|
CE1
|
B:TYR248
|
4.7
|
17.0
|
1.0
|
O
|
B:HOH701
|
4.9
|
20.6
|
0.5
|
CB
|
B:ASP191
|
4.9
|
14.0
|
1.0
|
O
|
B:HOH881
|
4.9
|
25.0
|
1.0
|
C
|
B:THR187
|
5.0
|
17.7
|
1.0
|
O
|
B:SER186
|
5.0
|
23.6
|
1.0
|
|
Fluorine binding site 5 out
of 8 in 6teq
Go back to
Fluorine Binding Sites List in 6teq
Fluorine binding site 5 out
of 8 in the Crystal Structure of A Galactokinase From Bifidobacterium Infantis in Complex with 2-Deoxy-2-Fluoro-Galactose
Mono view
Stereo pair view
|
A full contact list of Fluorine with other atoms in the F binding
site number 5 of Crystal Structure of A Galactokinase From Bifidobacterium Infantis in Complex with 2-Deoxy-2-Fluoro-Galactose within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
C:F615
b:20.9
occ:0.60
|
F2
|
C:GAF615
|
0.0
|
20.9
|
0.6
|
F2
|
C:2FG616
|
0.0
|
17.0
|
0.4
|
C2
|
C:2FG616
|
1.4
|
17.2
|
0.4
|
C2
|
C:GAF615
|
1.4
|
19.0
|
0.6
|
O
|
C:HOH711
|
2.3
|
14.4
|
1.0
|
C1
|
C:GAF615
|
2.3
|
16.8
|
0.6
|
C1
|
C:2FG616
|
2.4
|
16.6
|
0.4
|
C3
|
C:2FG616
|
2.4
|
16.1
|
0.4
|
C3
|
C:GAF615
|
2.4
|
17.7
|
0.6
|
O1
|
C:GAF615
|
2.7
|
20.6
|
0.6
|
O3
|
C:2FG616
|
2.8
|
14.6
|
0.4
|
O1
|
C:2FG616
|
2.9
|
22.3
|
0.4
|
O3
|
C:GAF615
|
2.9
|
18.0
|
0.6
|
O
|
C:HOH834
|
2.9
|
23.7
|
1.0
|
O2
|
C:GOL608
|
3.1
|
30.8
|
0.5
|
OG1
|
C:THR187
|
3.1
|
21.6
|
1.0
|
O
|
C:HOH845
|
3.2
|
16.9
|
1.0
|
OD2
|
C:ASP191
|
3.3
|
17.1
|
1.0
|
O
|
C:HOH750
|
3.5
|
30.0
|
1.0
|
O5
|
C:GAF615
|
3.5
|
19.1
|
0.6
|
O5
|
C:2FG616
|
3.6
|
17.3
|
0.4
|
C4
|
C:2FG616
|
3.7
|
14.8
|
0.4
|
C4
|
C:GAF615
|
3.8
|
16.0
|
0.6
|
CG
|
C:ASP191
|
3.8
|
15.1
|
1.0
|
C2
|
C:GOL608
|
3.9
|
24.7
|
0.5
|
OD1
|
C:ASP191
|
4.0
|
14.1
|
1.0
|
CB
|
C:THR187
|
4.0
|
19.8
|
1.0
|
C5
|
C:GAF615
|
4.1
|
16.4
|
0.6
|
C5
|
C:2FG616
|
4.1
|
15.2
|
0.4
|
OH
|
C:TYR248
|
4.2
|
16.1
|
1.0
|
CA
|
C:THR187
|
4.3
|
19.3
|
1.0
|
C1
|
C:GOL608
|
4.3
|
21.2
|
0.5
|
O4
|
C:GAF615
|
4.3
|
15.5
|
0.6
|
O4
|
C:2FG616
|
4.3
|
14.7
|
0.4
|
N
|
C:GLY188
|
4.4
|
18.2
|
1.0
|
O
|
C:HOH710
|
4.5
|
20.1
|
1.0
|
CZ
|
C:TYR248
|
4.6
|
15.9
|
1.0
|
O
|
C:GLY188
|
4.7
|
19.1
|
1.0
|
CE1
|
C:TYR248
|
4.8
|
18.6
|
1.0
|
C
|
C:THR187
|
4.9
|
17.8
|
1.0
|
CB
|
C:ASP191
|
4.9
|
15.8
|
1.0
|
O
|
C:HOH701
|
4.9
|
23.1
|
0.5
|
O
|
C:SER186
|
5.0
|
21.9
|
1.0
|
|
Fluorine binding site 6 out
of 8 in 6teq
Go back to
Fluorine Binding Sites List in 6teq
Fluorine binding site 6 out
of 8 in the Crystal Structure of A Galactokinase From Bifidobacterium Infantis in Complex with 2-Deoxy-2-Fluoro-Galactose
Mono view
Stereo pair view
|
A full contact list of Fluorine with other atoms in the F binding
site number 6 of Crystal Structure of A Galactokinase From Bifidobacterium Infantis in Complex with 2-Deoxy-2-Fluoro-Galactose within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
C:F616
b:17.0
occ:0.40
|
F2
|
C:2FG616
|
0.0
|
17.0
|
0.4
|
F2
|
C:GAF615
|
0.0
|
20.9
|
0.6
|
C2
|
C:2FG616
|
1.4
|
17.2
|
0.4
|
C2
|
C:GAF615
|
1.4
|
19.0
|
0.6
|
O
|
C:HOH711
|
2.3
|
14.4
|
1.0
|
C1
|
C:GAF615
|
2.3
|
16.8
|
0.6
|
C1
|
C:2FG616
|
2.3
|
16.6
|
0.4
|
C3
|
C:2FG616
|
2.4
|
16.1
|
0.4
|
C3
|
C:GAF615
|
2.4
|
17.7
|
0.6
|
O1
|
C:GAF615
|
2.6
|
20.6
|
0.6
|
O1
|
C:2FG616
|
2.8
|
22.3
|
0.4
|
O3
|
C:2FG616
|
2.9
|
14.6
|
0.4
|
O3
|
C:GAF615
|
2.9
|
18.0
|
0.6
|
O
|
C:HOH834
|
2.9
|
23.7
|
1.0
|
O2
|
C:GOL608
|
3.1
|
30.8
|
0.5
|
OG1
|
C:THR187
|
3.2
|
21.6
|
1.0
|
O
|
C:HOH845
|
3.2
|
16.9
|
1.0
|
OD2
|
C:ASP191
|
3.2
|
17.1
|
1.0
|
O
|
C:HOH750
|
3.4
|
30.0
|
1.0
|
O5
|
C:GAF615
|
3.5
|
19.1
|
0.6
|
O5
|
C:2FG616
|
3.5
|
17.3
|
0.4
|
C4
|
C:2FG616
|
3.7
|
14.8
|
0.4
|
C4
|
C:GAF615
|
3.7
|
16.0
|
0.6
|
CG
|
C:ASP191
|
3.8
|
15.1
|
1.0
|
C2
|
C:GOL608
|
4.0
|
24.7
|
0.5
|
OD1
|
C:ASP191
|
4.0
|
14.1
|
1.0
|
C5
|
C:GAF615
|
4.1
|
16.4
|
0.6
|
C5
|
C:2FG616
|
4.1
|
15.2
|
0.4
|
CB
|
C:THR187
|
4.1
|
19.8
|
1.0
|
OH
|
C:TYR248
|
4.2
|
16.1
|
1.0
|
C1
|
C:GOL608
|
4.3
|
21.2
|
0.5
|
CA
|
C:THR187
|
4.3
|
19.3
|
1.0
|
O4
|
C:GAF615
|
4.3
|
15.5
|
0.6
|
O4
|
C:2FG616
|
4.3
|
14.7
|
0.4
|
N
|
C:GLY188
|
4.4
|
18.2
|
1.0
|
O
|
C:HOH710
|
4.5
|
20.1
|
1.0
|
CZ
|
C:TYR248
|
4.6
|
15.9
|
1.0
|
O
|
C:GLY188
|
4.8
|
19.1
|
1.0
|
CE1
|
C:TYR248
|
4.8
|
18.6
|
1.0
|
C
|
C:THR187
|
4.9
|
17.8
|
1.0
|
CB
|
C:ASP191
|
4.9
|
15.8
|
1.0
|
O
|
C:HOH701
|
4.9
|
23.1
|
0.5
|
O1
|
C:GOL608
|
5.0
|
26.5
|
0.5
|
O
|
C:HOH853
|
5.0
|
22.8
|
1.0
|
|
Fluorine binding site 7 out
of 8 in 6teq
Go back to
Fluorine Binding Sites List in 6teq
Fluorine binding site 7 out
of 8 in the Crystal Structure of A Galactokinase From Bifidobacterium Infantis in Complex with 2-Deoxy-2-Fluoro-Galactose
Mono view
Stereo pair view
|
A full contact list of Fluorine with other atoms in the F binding
site number 7 of Crystal Structure of A Galactokinase From Bifidobacterium Infantis in Complex with 2-Deoxy-2-Fluoro-Galactose within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
D:F705
b:24.5
occ:0.60
|
F2
|
D:2FG705
|
0.0
|
24.5
|
0.6
|
F2
|
D:GAF706
|
0.0
|
20.6
|
0.4
|
C2
|
D:GAF706
|
1.3
|
18.0
|
0.4
|
C2
|
D:2FG705
|
1.3
|
24.0
|
0.6
|
C1
|
D:2FG705
|
2.3
|
26.9
|
0.6
|
C1
|
D:GAF706
|
2.3
|
18.4
|
0.4
|
C3
|
D:GAF706
|
2.4
|
17.5
|
0.4
|
O
|
D:HOH805
|
2.4
|
19.0
|
1.0
|
C3
|
D:2FG705
|
2.4
|
22.1
|
0.6
|
O1
|
D:2FG705
|
2.6
|
31.9
|
0.6
|
O1
|
D:GAF706
|
2.8
|
17.4
|
0.4
|
O3
|
D:GAF706
|
2.9
|
16.2
|
0.4
|
O3
|
D:2FG705
|
2.9
|
20.5
|
0.6
|
O
|
D:HOH967
|
2.9
|
30.0
|
1.0
|
O
|
D:HOH883
|
3.0
|
30.2
|
0.6
|
OG1
|
D:THR187
|
3.1
|
24.9
|
1.0
|
OD2
|
D:ASP191
|
3.2
|
21.2
|
1.0
|
O
|
D:HOH909
|
3.4
|
18.3
|
1.0
|
O5
|
D:GAF706
|
3.5
|
16.8
|
0.4
|
O
|
D:HOH871
|
3.5
|
22.5
|
0.5
|
O5
|
D:2FG705
|
3.6
|
25.2
|
0.6
|
C4
|
D:GAF706
|
3.7
|
16.0
|
0.4
|
C4
|
D:2FG705
|
3.8
|
19.5
|
0.6
|
CG
|
D:ASP191
|
3.8
|
17.9
|
1.0
|
CB
|
D:THR187
|
4.0
|
24.2
|
1.0
|
OD1
|
D:ASP191
|
4.0
|
16.7
|
1.0
|
C5
|
D:GAF706
|
4.1
|
17.4
|
0.4
|
C5
|
D:2FG705
|
4.1
|
22.2
|
0.6
|
OH
|
D:TYR248
|
4.2
|
20.7
|
1.0
|
CA
|
D:THR187
|
4.3
|
19.7
|
1.0
|
O4
|
D:GAF706
|
4.3
|
17.4
|
0.4
|
O4
|
D:2FG705
|
4.4
|
19.8
|
0.6
|
O
|
D:HOH803
|
4.4
|
29.2
|
1.0
|
N
|
D:GLY188
|
4.4
|
20.8
|
1.0
|
CZ
|
D:TYR248
|
4.5
|
20.4
|
1.0
|
CE1
|
D:TYR248
|
4.7
|
21.2
|
1.0
|
C
|
D:THR187
|
4.9
|
21.1
|
1.0
|
CB
|
D:ASP191
|
4.9
|
16.9
|
1.0
|
O
|
D:HOH891
|
5.0
|
29.6
|
1.0
|
O
|
D:SER186
|
5.0
|
28.1
|
1.0
|
|
Fluorine binding site 8 out
of 8 in 6teq
Go back to
Fluorine Binding Sites List in 6teq
Fluorine binding site 8 out
of 8 in the Crystal Structure of A Galactokinase From Bifidobacterium Infantis in Complex with 2-Deoxy-2-Fluoro-Galactose
Mono view
Stereo pair view
|
A full contact list of Fluorine with other atoms in the F binding
site number 8 of Crystal Structure of A Galactokinase From Bifidobacterium Infantis in Complex with 2-Deoxy-2-Fluoro-Galactose within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
D:F706
b:20.6
occ:0.40
|
F2
|
D:GAF706
|
0.0
|
20.6
|
0.4
|
F2
|
D:2FG705
|
0.0
|
24.5
|
0.6
|
C2
|
D:GAF706
|
1.3
|
18.0
|
0.4
|
C2
|
D:2FG705
|
1.4
|
24.0
|
0.6
|
C1
|
D:2FG705
|
2.3
|
26.9
|
0.6
|
C1
|
D:GAF706
|
2.3
|
18.4
|
0.4
|
O
|
D:HOH805
|
2.4
|
19.0
|
1.0
|
C3
|
D:GAF706
|
2.4
|
17.5
|
0.4
|
C3
|
D:2FG705
|
2.5
|
22.1
|
0.6
|
O1
|
D:2FG705
|
2.7
|
31.9
|
0.6
|
O1
|
D:GAF706
|
2.8
|
17.4
|
0.4
|
O3
|
D:GAF706
|
2.9
|
16.2
|
0.4
|
O3
|
D:2FG705
|
2.9
|
20.5
|
0.6
|
O
|
D:HOH967
|
2.9
|
30.0
|
1.0
|
O
|
D:HOH883
|
2.9
|
30.2
|
0.6
|
OG1
|
D:THR187
|
3.1
|
24.9
|
1.0
|
OD2
|
D:ASP191
|
3.2
|
21.2
|
1.0
|
O
|
D:HOH909
|
3.4
|
18.3
|
1.0
|
O
|
D:HOH871
|
3.5
|
22.5
|
0.5
|
O5
|
D:GAF706
|
3.6
|
16.8
|
0.4
|
O5
|
D:2FG705
|
3.6
|
25.2
|
0.6
|
C4
|
D:GAF706
|
3.7
|
16.0
|
0.4
|
C4
|
D:2FG705
|
3.8
|
19.5
|
0.6
|
CG
|
D:ASP191
|
3.8
|
17.9
|
1.0
|
CB
|
D:THR187
|
4.0
|
24.2
|
1.0
|
OD1
|
D:ASP191
|
4.1
|
16.7
|
1.0
|
C5
|
D:GAF706
|
4.1
|
17.4
|
0.4
|
C5
|
D:2FG705
|
4.1
|
22.2
|
0.6
|
OH
|
D:TYR248
|
4.2
|
20.7
|
1.0
|
CA
|
D:THR187
|
4.3
|
19.7
|
1.0
|
O4
|
D:GAF706
|
4.4
|
17.4
|
0.4
|
O4
|
D:2FG705
|
4.4
|
19.8
|
0.6
|
O
|
D:HOH803
|
4.4
|
29.2
|
1.0
|
N
|
D:GLY188
|
4.4
|
20.8
|
1.0
|
CZ
|
D:TYR248
|
4.5
|
20.4
|
1.0
|
CE1
|
D:TYR248
|
4.7
|
21.2
|
1.0
|
C
|
D:THR187
|
4.9
|
21.1
|
1.0
|
CB
|
D:ASP191
|
4.9
|
16.9
|
1.0
|
O
|
D:SER186
|
4.9
|
28.1
|
1.0
|
O
|
D:HOH891
|
5.0
|
29.6
|
1.0
|
|
Reference:
T.Keenan,
F.Parmeggiani,
C.Q.Fontenelle,
J.Malassis,
J.Vendeville,
W.A.Offen,
P.Both,
K.Huang,
A.Marchesi,
A.Heyam,
C.Young,
S.Charnock,
G.J.Davies,
B.Linclau,
S.L.Flitsch,
M.A.Fascione.
Substrate Promiscuity of Wild-Type Sugar Kinases: Chemo-Enzymatic Synthesis of Multi-Fluorinated Monosaccharide-1-Phosphates. To Be Published.
Page generated: Fri Aug 2 02:02:35 2024
|