|
Atomistry » Fluorine » PDB 6taw-6tuf » 6thz | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 6taw-6tuf » 6thz » |
Fluorine in PDB 6thz: IRAK4 in Complex with InhibitorEnzymatic activity of IRAK4 in Complex with Inhibitor
All present enzymatic activity of IRAK4 in Complex with Inhibitor:
2.7.11.1; Protein crystallography data
The structure of IRAK4 in Complex with Inhibitor, PDB code: 6thz
was solved by
Y.Xue,
A.Aagaard,
S.L.Degorce,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the IRAK4 in Complex with Inhibitor
(pdb code 6thz). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the IRAK4 in Complex with Inhibitor, PDB code: 6thz: Jump to Fluorine binding site number: 1; 2; Fluorine binding site 1 out of 2 in 6thzGo back to Fluorine Binding Sites List in 6thz
Fluorine binding site 1 out
of 2 in the IRAK4 in Complex with Inhibitor
Mono view Stereo pair view
Fluorine binding site 2 out of 2 in 6thzGo back to Fluorine Binding Sites List in 6thz
Fluorine binding site 2 out
of 2 in the IRAK4 in Complex with Inhibitor
Mono view Stereo pair view
Reference:
S.L.Degorce,
A.Aagaard,
R.Anjum,
I.A.Cumming,
C.R.Diene,
C.Fallan,
T.Johnson,
K.J.Leuchowius,
A.L.Orton,
S.Pearson,
G.R.Robb,
A.Rosen,
G.B.Scarfe,
J.S.Scott,
J.M.Smith,
O.R.Steward,
I.Terstiege,
M.J.Tucker,
P.Turner,
S.D.Wilkinson,
G.L.Wrigley,
Y.Xue.
Improving Metabolic Stability and Removing Aldehyde Oxidase Liability in A 5-Azaquinazoline Series of IRAK4 Inhibitors. Bioorg.Med.Chem. V. 28 15815 2020.
Page generated: Fri Aug 2 02:04:43 2024
ISSN: ESSN 1464-3391 PubMed: 33091850 DOI: 10.1016/J.BMC.2020.115815 |
Last articlesZn in 9JYWZn in 9IR4 Zn in 9IR3 Zn in 9GMX Zn in 9GMW Zn in 9JEJ Zn in 9ERF Zn in 9ERE Zn in 9EGV Zn in 9EGW |
© Copyright 2008-2020 by atomistry.com | ||
Home | Site Map | Copyright | Contact us | Privacy |