Fluorine in PDB 6tiw: Human Kinesin-5 Motor Domain in the Gsk State Bound to Microtubules (Conformation 2)
Other elements in 6tiw:
The structure of Human Kinesin-5 Motor Domain in the Gsk State Bound to Microtubules (Conformation 2) also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Human Kinesin-5 Motor Domain in the Gsk State Bound to Microtubules (Conformation 2)
(pdb code 6tiw). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the
Human Kinesin-5 Motor Domain in the Gsk State Bound to Microtubules (Conformation 2), PDB code: 6tiw:
Jump to Fluorine binding site number:
1;
2;
3;
Fluorine binding site 1 out
of 3 in 6tiw
Go back to
Fluorine Binding Sites List in 6tiw
Fluorine binding site 1 out
of 3 in the Human Kinesin-5 Motor Domain in the Gsk State Bound to Microtubules (Conformation 2)
Mono view
Stereo pair view
|
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Human Kinesin-5 Motor Domain in the Gsk State Bound to Microtubules (Conformation 2) within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
K:F501
b:0.0
occ:1.00
|
F1
|
K:MZK501
|
0.0
|
0.0
|
1.0
|
C16
|
K:MZK501
|
1.4
|
0.0
|
1.0
|
F2
|
K:MZK501
|
2.2
|
0.0
|
1.0
|
F3
|
K:MZK501
|
2.2
|
0.0
|
1.0
|
C13
|
K:MZK501
|
2.4
|
0.0
|
1.0
|
C14
|
K:MZK501
|
2.7
|
0.0
|
1.0
|
CG
|
K:ARG355
|
3.3
|
0.7
|
1.0
|
O
|
K:GLY296
|
3.5
|
0.7
|
1.0
|
C15
|
K:MZK501
|
3.7
|
0.0
|
1.0
|
CA
|
K:GLY296
|
3.7
|
0.7
|
1.0
|
NH1
|
K:ARG355
|
3.7
|
0.7
|
1.0
|
CG2
|
K:THR300
|
3.8
|
0.8
|
1.0
|
CB
|
K:ILE299
|
3.9
|
0.7
|
1.0
|
CZ
|
K:ARG355
|
3.9
|
0.7
|
1.0
|
C
|
K:GLY296
|
3.9
|
0.7
|
1.0
|
NE
|
K:ARG355
|
4.1
|
0.7
|
1.0
|
C11
|
K:MZK501
|
4.1
|
0.0
|
1.0
|
CD
|
K:ARG355
|
4.1
|
0.7
|
1.0
|
CB
|
K:ARG355
|
4.2
|
0.7
|
1.0
|
CG2
|
K:ILE299
|
4.2
|
0.7
|
1.0
|
N
|
K:THR300
|
4.5
|
0.8
|
1.0
|
NH2
|
K:ARG355
|
4.5
|
0.7
|
1.0
|
CG1
|
K:ILE299
|
4.6
|
0.7
|
1.0
|
CA
|
K:TYR352
|
4.7
|
0.7
|
1.0
|
C12
|
K:MZK501
|
4.8
|
0.0
|
1.0
|
CD2
|
K:TYR352
|
4.9
|
0.7
|
1.0
|
N
|
K:TYR352
|
4.9
|
0.7
|
1.0
|
C
|
K:ILE299
|
4.9
|
0.7
|
1.0
|
C
|
K:GLU351
|
5.0
|
0.7
|
1.0
|
C9
|
K:MZK501
|
5.0
|
0.0
|
1.0
|
|
Fluorine binding site 2 out
of 3 in 6tiw
Go back to
Fluorine Binding Sites List in 6tiw
Fluorine binding site 2 out
of 3 in the Human Kinesin-5 Motor Domain in the Gsk State Bound to Microtubules (Conformation 2)
Mono view
Stereo pair view
|
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Human Kinesin-5 Motor Domain in the Gsk State Bound to Microtubules (Conformation 2) within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
K:F501
b:0.0
occ:1.00
|
F2
|
K:MZK501
|
0.0
|
0.0
|
1.0
|
C16
|
K:MZK501
|
1.4
|
0.0
|
1.0
|
F1
|
K:MZK501
|
2.2
|
0.0
|
1.0
|
F3
|
K:MZK501
|
2.2
|
0.0
|
1.0
|
C13
|
K:MZK501
|
2.4
|
0.0
|
1.0
|
CG2
|
K:ILE299
|
2.7
|
0.7
|
1.0
|
CB
|
K:ILE299
|
2.7
|
0.7
|
1.0
|
C15
|
K:MZK501
|
2.9
|
0.0
|
1.0
|
CD2
|
K:TYR352
|
3.0
|
0.7
|
1.0
|
CE2
|
K:TYR352
|
3.1
|
0.7
|
1.0
|
CG1
|
K:ILE299
|
3.1
|
0.7
|
1.0
|
CG
|
K:ARG355
|
3.3
|
0.7
|
1.0
|
CB
|
K:ARG355
|
3.4
|
0.7
|
1.0
|
C14
|
K:MZK501
|
3.5
|
0.0
|
1.0
|
CA
|
K:TYR352
|
3.9
|
0.7
|
1.0
|
CG
|
K:TYR352
|
4.0
|
0.7
|
1.0
|
CZ
|
K:TYR352
|
4.0
|
0.7
|
1.0
|
O
|
K:GLY296
|
4.1
|
0.7
|
1.0
|
CA
|
K:GLY296
|
4.1
|
0.7
|
1.0
|
CA
|
K:ILE299
|
4.2
|
0.7
|
1.0
|
C12
|
K:MZK501
|
4.3
|
0.0
|
1.0
|
CB
|
K:TYR352
|
4.3
|
0.7
|
1.0
|
CD1
|
K:ILE299
|
4.3
|
0.7
|
1.0
|
O
|
K:TYR352
|
4.5
|
0.7
|
1.0
|
C
|
K:ILE299
|
4.6
|
0.7
|
1.0
|
CD1
|
K:TYR352
|
4.6
|
0.7
|
1.0
|
C
|
K:GLY296
|
4.6
|
0.7
|
1.0
|
CE1
|
K:TYR352
|
4.6
|
0.7
|
1.0
|
OH
|
K:TYR352
|
4.7
|
0.7
|
1.0
|
CD2
|
K:LEU295
|
4.7
|
0.7
|
1.0
|
CD
|
K:ARG355
|
4.7
|
0.7
|
1.0
|
C11
|
K:MZK501
|
4.7
|
0.0
|
1.0
|
C
|
K:TYR352
|
4.7
|
0.7
|
1.0
|
N
|
K:THR300
|
4.7
|
0.8
|
1.0
|
N
|
K:TYR352
|
4.8
|
0.7
|
1.0
|
CA
|
K:ARG355
|
4.9
|
0.7
|
1.0
|
N
|
K:ILE299
|
4.9
|
0.7
|
1.0
|
C9
|
K:MZK501
|
5.0
|
0.0
|
1.0
|
O
|
K:LEU295
|
5.0
|
0.7
|
1.0
|
|
Fluorine binding site 3 out
of 3 in 6tiw
Go back to
Fluorine Binding Sites List in 6tiw
Fluorine binding site 3 out
of 3 in the Human Kinesin-5 Motor Domain in the Gsk State Bound to Microtubules (Conformation 2)
Mono view
Stereo pair view
|
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Human Kinesin-5 Motor Domain in the Gsk State Bound to Microtubules (Conformation 2) within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
K:F501
b:0.0
occ:1.00
|
F3
|
K:MZK501
|
0.0
|
0.0
|
1.0
|
C16
|
K:MZK501
|
1.4
|
0.0
|
1.0
|
F2
|
K:MZK501
|
2.2
|
0.0
|
1.0
|
F1
|
K:MZK501
|
2.2
|
0.0
|
1.0
|
CG
|
K:ARG355
|
2.3
|
0.7
|
1.0
|
C13
|
K:MZK501
|
2.4
|
0.0
|
1.0
|
CA
|
K:TYR352
|
2.6
|
0.7
|
1.0
|
N
|
K:TYR352
|
2.9
|
0.7
|
1.0
|
C15
|
K:MZK501
|
3.1
|
0.0
|
1.0
|
C
|
K:GLU351
|
3.1
|
0.7
|
1.0
|
CB
|
K:ARG355
|
3.2
|
0.7
|
1.0
|
O
|
K:GLU351
|
3.2
|
0.7
|
1.0
|
C14
|
K:MZK501
|
3.4
|
0.0
|
1.0
|
CD
|
K:ARG355
|
3.4
|
0.7
|
1.0
|
CD2
|
K:TYR352
|
3.4
|
0.7
|
1.0
|
NE
|
K:ARG355
|
3.5
|
0.7
|
1.0
|
CB
|
K:TYR352
|
3.5
|
0.7
|
1.0
|
C
|
K:TYR352
|
3.6
|
0.7
|
1.0
|
O
|
K:TYR352
|
3.7
|
0.7
|
1.0
|
CZ
|
K:ARG355
|
4.0
|
0.7
|
1.0
|
CB
|
K:GLU351
|
4.0
|
0.7
|
1.0
|
CG
|
K:TYR352
|
4.1
|
0.7
|
1.0
|
CA
|
K:GLU351
|
4.2
|
0.7
|
1.0
|
CE2
|
K:TYR352
|
4.3
|
0.7
|
1.0
|
CG2
|
K:ILE299
|
4.3
|
0.7
|
1.0
|
NH1
|
K:ARG355
|
4.3
|
0.7
|
1.0
|
C12
|
K:MZK501
|
4.3
|
0.0
|
1.0
|
N
|
K:ARG355
|
4.4
|
0.7
|
1.0
|
CA
|
K:ARG355
|
4.4
|
0.7
|
1.0
|
C11
|
K:MZK501
|
4.6
|
0.0
|
1.0
|
NH2
|
K:ARG355
|
4.6
|
0.7
|
1.0
|
N
|
K:ALA353
|
4.7
|
0.7
|
1.0
|
CB
|
K:ILE299
|
4.7
|
0.7
|
1.0
|
O
|
K:SER348
|
4.8
|
0.7
|
1.0
|
C9
|
K:MZK501
|
5.0
|
0.0
|
1.0
|
|
Reference:
A.Pena,
A.Sweeney,
A.D.Cook,
M.Topf,
C.A.Moores.
Structure of Microtubule-Trapped Human Kinesin-5 and Its Mechanism of Inhibition Revealed Using Cryoelectron Microscopy. Structure 2020.
ISSN: ISSN 0969-2126
PubMed: 32084356
DOI: 10.1016/J.STR.2020.01.013
Page generated: Fri Aug 2 02:05:00 2024
|