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Fluorine in PDB 6tp6: Crystal Structure of the Orexin-1 Receptor in Complex with FilorexantProtein crystallography data
The structure of Crystal Structure of the Orexin-1 Receptor in Complex with Filorexant, PDB code: 6tp6
was solved by
M.Rappas,
A.Ali,
K.A.Bennett,
J.D.Brown,
S.J.Bucknell,
M.Congreve,
R.M.Cooke,
G.Cseke,
C.De Graaf,
A.S.Dore,
J.C.Errey,
A.Jazayeri,
F.H.Marshall,
J.S.Mason,
R.Mould,
J.C.Patel,
B.G.Tehan,
M.Weir,
J.A.Christopher,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 6tp6:
The structure of Crystal Structure of the Orexin-1 Receptor in Complex with Filorexant also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of the Orexin-1 Receptor in Complex with Filorexant
(pdb code 6tp6). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Crystal Structure of the Orexin-1 Receptor in Complex with Filorexant, PDB code: 6tp6: Jump to Fluorine binding site number: 1; 2; Fluorine binding site 1 out of 2 in 6tp6Go back to Fluorine Binding Sites List in 6tp6
Fluorine binding site 1 out
of 2 in the Crystal Structure of the Orexin-1 Receptor in Complex with Filorexant
Mono view Stereo pair view
Fluorine binding site 2 out of 2 in 6tp6Go back to Fluorine Binding Sites List in 6tp6
Fluorine binding site 2 out
of 2 in the Crystal Structure of the Orexin-1 Receptor in Complex with Filorexant
Mono view Stereo pair view
Reference:
M.Rappas,
A.Ali,
K.A.Bennett,
J.D.Brown,
S.J.Bucknell,
M.Congreve,
R.M.Cooke,
G.Cseke,
C.De Graaf,
A.S.Dore,
J.C.Errey,
A.Jazayeri,
F.H.Marshall,
J.S.Mason,
R.Mould,
J.C.Patel,
B.Tehan,
M.Weir,
J.A.Christopher.
Comparison of Orexin 1 and Orexin 2 Ligand Binding Modes Using X-Ray Crystallography and Computational Analysis. J.Med.Chem. 2019.
Page generated: Sun Dec 13 13:15:40 2020
ISSN: ISSN 0022-2623 PubMed: 31860301 DOI: 10.1021/ACS.JMEDCHEM.9B01787 |
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