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Atomistry » Fluorine » PDB 6taw-6tuf » 6tpa | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 6taw-6tuf » 6tpa » |
Fluorine in PDB 6tpa: CDK8/Cyclinc in Complex with Drug Etp-50775Enzymatic activity of CDK8/Cyclinc in Complex with Drug Etp-50775
All present enzymatic activity of CDK8/Cyclinc in Complex with Drug Etp-50775:
2.7.11.22; 2.7.11.23; Protein crystallography data
The structure of CDK8/Cyclinc in Complex with Drug Etp-50775, PDB code: 6tpa
was solved by
I.G.Munoz,
J.Pastor,
S.Martinez,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 6tpa:
The structure of CDK8/Cyclinc in Complex with Drug Etp-50775 also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the CDK8/Cyclinc in Complex with Drug Etp-50775
(pdb code 6tpa). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the CDK8/Cyclinc in Complex with Drug Etp-50775, PDB code: 6tpa: Jump to Fluorine binding site number: 1; 2; 3; Fluorine binding site 1 out of 3 in 6tpaGo back to Fluorine Binding Sites List in 6tpa
Fluorine binding site 1 out
of 3 in the CDK8/Cyclinc in Complex with Drug Etp-50775
Mono view Stereo pair view
Fluorine binding site 2 out of 3 in 6tpaGo back to Fluorine Binding Sites List in 6tpa
Fluorine binding site 2 out
of 3 in the CDK8/Cyclinc in Complex with Drug Etp-50775
Mono view Stereo pair view
Fluorine binding site 3 out of 3 in 6tpaGo back to Fluorine Binding Sites List in 6tpa
Fluorine binding site 3 out
of 3 in the CDK8/Cyclinc in Complex with Drug Etp-50775
Mono view Stereo pair view
Reference:
S.Martinez-Gonzalez,
A.B.Garcia,
M.I.Albarran,
A.Cebria,
A.Amezquita-Alves,
F.J.Garcia-Campos,
J.Martinez-Gago,
J.Martinez-Torrecuadrada,
I.Munoz,
C.Blanco-Aparicio,
J.Pastor.
Pyrido[2,3-B][1,5]Benzoxazepin-5(6H)-One Derivatives As CDK8 Inhibitors. Eur.J.Med.Chem. V. 201 12443 2020.
Page generated: Fri Aug 2 02:06:56 2024
ISSN: ISSN 0223-5234 PubMed: 32599324 DOI: 10.1016/J.EJMECH.2020.112443 |
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