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Atomistry » Fluorine » PDB 6taw-6tuf » 6tpf | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 6taw-6tuf » 6tpf » |
Fluorine in PDB 6tpf: Fragment-Based Discovery of Pyrazolopyridones As JAK1 Inhibitors with Excellent Subtype SelectivityEnzymatic activity of Fragment-Based Discovery of Pyrazolopyridones As JAK1 Inhibitors with Excellent Subtype Selectivity
All present enzymatic activity of Fragment-Based Discovery of Pyrazolopyridones As JAK1 Inhibitors with Excellent Subtype Selectivity:
2.7.10.2; Protein crystallography data
The structure of Fragment-Based Discovery of Pyrazolopyridones As JAK1 Inhibitors with Excellent Subtype Selectivity, PDB code: 6tpf
was solved by
B.B.Hansen,
T.H.Jepsen,
M.Larsen,
R.Sindet,
T.Vifian,
M.N.Burhardt,
J.Larsen,
J.G.Seitzberg,
M.A.Carnerup,
A.Jerre,
C.Molck,
S.Rai,
V.R.Nasipireddy,
A.Griessner,
A.Ritzen,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Fragment-Based Discovery of Pyrazolopyridones As JAK1 Inhibitors with Excellent Subtype Selectivity
(pdb code 6tpf). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 4 binding sites of Fluorine where determined in the Fragment-Based Discovery of Pyrazolopyridones As JAK1 Inhibitors with Excellent Subtype Selectivity, PDB code: 6tpf: Jump to Fluorine binding site number: 1; 2; 3; 4; Fluorine binding site 1 out of 4 in 6tpfGo back to Fluorine Binding Sites List in 6tpf
Fluorine binding site 1 out
of 4 in the Fragment-Based Discovery of Pyrazolopyridones As JAK1 Inhibitors with Excellent Subtype Selectivity
Mono view Stereo pair view
Fluorine binding site 2 out of 4 in 6tpfGo back to Fluorine Binding Sites List in 6tpf
Fluorine binding site 2 out
of 4 in the Fragment-Based Discovery of Pyrazolopyridones As JAK1 Inhibitors with Excellent Subtype Selectivity
Mono view Stereo pair view
Fluorine binding site 3 out of 4 in 6tpfGo back to Fluorine Binding Sites List in 6tpf
Fluorine binding site 3 out
of 4 in the Fragment-Based Discovery of Pyrazolopyridones As JAK1 Inhibitors with Excellent Subtype Selectivity
Mono view Stereo pair view
Fluorine binding site 4 out of 4 in 6tpfGo back to Fluorine Binding Sites List in 6tpf
Fluorine binding site 4 out
of 4 in the Fragment-Based Discovery of Pyrazolopyridones As JAK1 Inhibitors with Excellent Subtype Selectivity
Mono view Stereo pair view
Reference:
B.B.Hansen,
T.H.Jepsen,
M.Larsen,
R.Sindet,
T.Vifian,
M.N.Burhardt,
J.Larsen,
J.G.Seitzberg,
M.A.Carnerup,
A.Jerre,
C.Molck,
P.Lovato,
S.Rai,
V.R.Nasipireddy,
A.Ritzen.
Fragment-Based Discovery of Pyrazolopyridones As JAK1 Inhibitors with Excellent Subtype Selectivity. J.Med.Chem. 2020.
Page generated: Fri Aug 2 02:07:19 2024
ISSN: ISSN 0022-2623 PubMed: 32462873 DOI: 10.1021/ACS.JMEDCHEM.0C00359 |
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