Fluorine in PDB 6ubw: Met Tyrosine Kinase Inhibition Enhances the Antitumor Efficacy of An Hgf Antibody

All present enzymatic activity of Met Tyrosine Kinase Inhibition Enhances the Antitumor Efficacy of An Hgf Antibody:
2.7.10.1;

The structure of Met Tyrosine Kinase Inhibition Enhances the Antitumor Efficacy of An Hgf Antibody, PDB code: 6ubw was solved by I.D.Hoffman, J.D.Lawson, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	25.00 / 2.00
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	42.414, 47.398, 160.607, 90.00, 90.00, 90.00
R / Rfree (%)	18.7 / 22.5

The structure of Met Tyrosine Kinase Inhibition Enhances the Antitumor Efficacy of An Hgf Antibody also contains other interesting chemical elements:

Chlorine

(Cl)

1 atom

The binding sites of Fluorine atom in the Met Tyrosine Kinase Inhibition Enhances the Antitumor Efficacy of An Hgf Antibody (pdb code 6ubw). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Met Tyrosine Kinase Inhibition Enhances the Antitumor Efficacy of An Hgf Antibody, PDB code: 6ubw:
Jump to Fluorine binding site number: 1; 2;

Fluorine binding site 1 out of 2 in the Met Tyrosine Kinase Inhibition Enhances the Antitumor Efficacy of An Hgf Antibody


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Met Tyrosine Kinase Inhibition Enhances the Antitumor Efficacy of An Hgf Antibody within 5.0Å range: probe atom residue distance (Å) B Occ A:F1401 b:35.5 occ:1.00 F32 A:84S1401 0.0 35.5 1.0 C21 A:84S1401 1.4 34.8 1.0 F33 A:84S1401 2.2 36.1 1.0 C8 A:84S1401 2.3 33.1 1.0 C15 A:84S1401 2.4 34.6 1.0 N26 A:84S1401 2.7 34.9 1.0 N29 A:84S1401 2.9 32.0 1.0 C13 A:84S1401 3.0 32.6 1.0 OH A:TYR1230 3.1 37.1 1.0 CG2 A:VAL1092 3.3 46.1 1.0 CE1 A:TYR1230 3.4 37.5 1.0 O A:HOH1626 3.4 49.5 1.0 CZ A:TYR1230 3.5 36.5 1.0 N25 A:84S1401 3.5 32.6 1.0 C11 A:84S1401 3.7 34.3 1.0 N27 A:84S1401 4.0 34.6 1.0 C7 A:84S1401 4.1 30.9 1.0 CG1 A:VAL1092 4.2 46.1 1.0 CB A:VAL1092 4.2 47.1 1.0 C14 A:84S1401 4.3 32.5 1.0 N24 A:84S1401 4.4 31.4 1.0 CD1 A:TYR1230 4.4 36.9 1.0 CE2 A:TYR1230 4.5 35.0 1.0 CD A:LYS1110 4.7 45.9 1.0 C9 A:84S1401 4.8 34.1 1.0 C6 A:84S1401 4.9 34.2 1.0 C3 A:84S1401 4.9 34.4 1.0 C1 A:84S1401 5.0 36.6 1.0

Fluorine binding site 2 out of 2 in the Met Tyrosine Kinase Inhibition Enhances the Antitumor Efficacy of An Hgf Antibody


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Met Tyrosine Kinase Inhibition Enhances the Antitumor Efficacy of An Hgf Antibody within 5.0Å range: probe atom residue distance (Å) B Occ A:F1401 b:36.1 occ:1.00 F33 A:84S1401 0.0 36.1 1.0 C21 A:84S1401 1.4 34.8 1.0 F32 A:84S1401 2.2 35.5 1.0 C8 A:84S1401 2.3 33.1 1.0 C15 A:84S1401 2.4 34.6 1.0 N25 A:84S1401 2.8 32.6 1.0 C11 A:84S1401 2.9 34.3 1.0 CD1 A:LEU1157 3.2 39.1 1.0 N26 A:84S1401 3.5 34.9 1.0 OH A:TYR1230 3.6 37.1 1.0 N29 A:84S1401 3.6 32.0 1.0 N24 A:84S1401 4.1 31.4 1.0 C9 A:84S1401 4.2 34.1 1.0 CG2 A:VAL1092 4.2 46.1 1.0 CD A:LYS1110 4.3 45.9 1.0 CB A:ALA1226 4.4 36.8 1.0 C13 A:84S1401 4.5 32.6 1.0 CG1 A:VAL1092 4.5 46.1 1.0 C7 A:84S1401 4.5 30.9 1.0 CZ A:TYR1230 4.6 36.5 1.0 N27 A:84S1401 4.6 34.6 1.0 CB A:LYS1110 4.6 47.8 1.0 CG A:LEU1157 4.6 39.4 1.0 C6 A:84S1401 4.9 34.2 1.0 CG A:LYS1110 5.0 47.7 1.0 CA A:ALA1226 5.0 38.6 1.0

P.J.Farrell, J.Matuszkiewicz, D.Balakrishna, S.Pandya, M.S.Hixon, R.Kamran, S.Chu, J.D.Lawson, K.Okada, A.Hori, A.Mizutani, H.Iwata, R.De Jong, B.Hibner, P.Vincent. Met Tyrosine Kinase Inhibition Enhances the Antitumor Efficacy of An Hgf Antibody. Mol. Cancer Ther. 2017.
ISSN: ESSN 1538-8514
PubMed: 28341789
DOI: 10.1158/1535-7163.MCT-16-0771