Fluorine in PDB 6ui2: Structure of Human Dna Polymerase Eta Complexed with N7MG in the Template Base Paired with Incoming Non-Hydrolyzable Ctp

Enzymatic activity of Structure of Human Dna Polymerase Eta Complexed with N7MG in the Template Base Paired with Incoming Non-Hydrolyzable Ctp

All present enzymatic activity of Structure of Human Dna Polymerase Eta Complexed with N7MG in the Template Base Paired with Incoming Non-Hydrolyzable Ctp:
2.7.7.7;

Protein crystallography data

The structure of Structure of Human Dna Polymerase Eta Complexed with N7MG in the Template Base Paired with Incoming Non-Hydrolyzable Ctp, PDB code: 6ui2 was solved by M.C.Koag, S.Lee, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 19.90 / 2.35
Space group P 61
Cell size a, b, c (Å), α, β, γ (°) 98.684, 98.684, 81.852, 90.00, 90.00, 120.00
R / Rfree (%) 17 / 23.7

Other elements in 6ui2:

The structure of Structure of Human Dna Polymerase Eta Complexed with N7MG in the Template Base Paired with Incoming Non-Hydrolyzable Ctp also contains other interesting chemical elements:

Magnesium (Mg) 2 atoms

Fluorine Binding Sites:

The binding sites of Fluorine atom in the Structure of Human Dna Polymerase Eta Complexed with N7MG in the Template Base Paired with Incoming Non-Hydrolyzable Ctp (pdb code 6ui2). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Structure of Human Dna Polymerase Eta Complexed with N7MG in the Template Base Paired with Incoming Non-Hydrolyzable Ctp, PDB code: 6ui2:

Fluorine binding site 1 out of 1 in 6ui2

Go back to Fluorine Binding Sites List in 6ui2
Fluorine binding site 1 out of 1 in the Structure of Human Dna Polymerase Eta Complexed with N7MG in the Template Base Paired with Incoming Non-Hydrolyzable Ctp


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Structure of Human Dna Polymerase Eta Complexed with N7MG in the Template Base Paired with Incoming Non-Hydrolyzable Ctp within 5.0Å range:
probe atom residue distance (Å) B Occ
T:F4

b:29.6
occ:1.00
F1' T:FMG4 0.0 29.6 1.0
C2' T:FMG4 1.4 30.2 1.0
C3' T:FMG4 2.3 29.2 1.0
C1' T:FMG4 2.4 27.2 1.0
N9 T:FMG4 2.7 31.8 1.0
ND2 A:ASN324 2.8 29.2 1.0
C8 T:FMG4 2.8 33.4 1.0
O4' T:FMG4 2.9 35.0 1.0
C4' T:FMG4 3.1 36.3 1.0
O3' T:FMG4 3.5 16.3 1.0
C5' T:FMG4 3.5 41.5 1.0
C8 T:DA5 3.6 15.6 1.0
N7 T:DA5 3.7 18.0 1.0
C4 T:FMG4 3.8 28.1 1.0
OP2 T:DA5 3.8 23.0 1.0
N7 T:FMG4 4.0 31.2 1.0
CG A:ASN324 4.0 26.5 1.0
P T:DA5 4.2 22.6 1.0
O5' T:DA5 4.3 18.7 1.0
C5 T:FMG4 4.4 30.8 1.0
O5' T:FMG4 4.4 49.3 1.0
OP2 T:FMG4 4.4 52.2 1.0
CB A:ASN324 4.6 22.3 1.0
N3 T:FMG4 4.7 23.7 1.0
N9 T:DA5 4.8 18.8 1.0
C5 T:DA5 4.9 20.1 1.0
OD1 A:ASN324 4.9 30.8 1.0
CM7 T:FMG4 5.0 25.6 1.0

Reference:

M.C.Koag, H.Jung, Y.Kou, S.Lee. Bypass of the Major Alkylative Dna Lesion By Human Dna Polymerase Eta. Molecules V. 24 2019.
ISSN: ESSN 1420-3049
PubMed: 31683505
DOI: 10.3390/MOLECULES24213928
Page generated: Sun Dec 13 13:18:08 2020

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