Fluorine in PDB 6ujz: Hiv-1 Wild-Type Reverse Transcriptase-Dna Complex with (+)-Ftc-Tp

Enzymatic activity of Hiv-1 Wild-Type Reverse Transcriptase-Dna Complex with (+)-Ftc-Tp

All present enzymatic activity of Hiv-1 Wild-Type Reverse Transcriptase-Dna Complex with (+)-Ftc-Tp:
2.7.7.49; 2.7.7.7; 3.1.26.13;

Protein crystallography data

The structure of Hiv-1 Wild-Type Reverse Transcriptase-Dna Complex with (+)-Ftc-Tp, PDB code: 6ujz was solved by E.B.Lansdon, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	47.34 / 2.56
*Space group*	C 2 2 2₁
*Cell size a, b, c (Å), α, β, γ (°)*	168.277, 168.829, 102.548, 90.00, 90.00, 90.00
*R / R_free (%)*	18.5 / 23.6

Other elements in 6ujz:

The structure of Hiv-1 Wild-Type Reverse Transcriptase-Dna Complex with (+)-Ftc-Tp also contains other interesting chemical elements:

Magnesium

(Mg)

1 atom

Fluorine Binding Sites:

The binding sites of Fluorine atom in the Hiv-1 Wild-Type Reverse Transcriptase-Dna Complex with (+)-Ftc-Tp (pdb code 6ujz). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Hiv-1 Wild-Type Reverse Transcriptase-Dna Complex with (+)-Ftc-Tp, PDB code: 6ujz:

Fluorine binding site 1 out of 1 in 6ujz

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Fluorine Binding Sites List in 6ujz

Fluorine binding site 1 out of 1 in the Hiv-1 Wild-Type Reverse Transcriptase-Dna Complex with (+)-Ftc-Tp

Mono view

Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Hiv-1 Wild-Type Reverse Transcriptase-Dna Complex with (+)-Ftc-Tp within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:F604 b:51.2 occ:1.00	FAJ	A:N8G604	0.0	51.2	1.0
	CAU	A:N8G604	1.3	51.6	1.0
	CAT	A:N8G604	2.4	51.3	1.0
	CAK	A:N8G604	2.4	49.4	1.0
	NAA	A:N8G604	2.6	56.0	1.0
	NH1	A:ARG72	3.5	69.4	1.0
	C5	P:DOC822	3.5	45.6	1.0
	NH2	A:ARG72	3.5	47.7	1.0
	CZ	A:ARG72	3.5	57.5	1.0
	NAN	A:N8G604	3.6	48.3	1.0
	C4	P:DOC822	3.6	45.9	1.0
	NAY	A:N8G604	3.6	48.9	1.0
	C6	P:DOC822	3.7	49.7	1.0
	N3	P:DOC822	3.9	52.2	1.0
	N1	P:DOC822	4.1	47.0	1.0
	N4	P:DOC822	4.1	46.1	1.0
	CAV	A:N8G604	4.1	47.5	1.0
	C2	P:DOC822	4.1	50.9	1.0
	NE	A:ARG72	4.3	56.9	1.0
	OAH	A:N8G604	4.4	49.5	1.0
	OAO	A:N8G604	4.5	48.3	1.0
	C1'	P:DOC822	4.8	49.9	1.0
	CAX	A:N8G604	4.9	44.2	1.0
	OAP	A:N8G604	4.9	47.5	1.0
	O2	P:DOC822	4.9	52.9	1.0
	C2'	P:DOC822	5.0	51.3	1.0
	PBA	A:N8G604	5.0	48.1	1.0

Reference:

M.Hung, E.J.Tokarsky, L.Lagpacan, L.Zhang, Z.Suo, E.B.Lansdon. Elucidating Molecular Interactions of L-Nucleotides with Hiv-1 Reverse Transcriptase and Mechanism of M184V-Caused Drug Resistance Commun Biol V. 2 2019.
ISSN: ESSN 2399-3642
DOI: 10.1038/S42003-019-0706-X

Page generated: Fri Aug 2 02:34:30 2024

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