Fluorine in PDB 6uz0: Cardiac Sodium Channel with Flecainide

The binding sites of Fluorine atom in the Cardiac Sodium Channel with Flecainide (pdb code 6uz0). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 6 binding sites of Fluorine where determined in the Cardiac Sodium Channel with Flecainide, PDB code: 6uz0:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6;

Fluorine binding site 1 out of 6 in the Cardiac Sodium Channel with Flecainide


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Cardiac Sodium Channel with Flecainide within 5.0Å range: probe atom residue distance (Å) B Occ A:F3026 b:32.2 occ:1.00 F01 A:K4D3026 0.0 32.2 1.0 C02 A:K4D3026 1.4 32.2 1.0 F04 A:K4D3026 2.1 32.2 1.0 F03 A:K4D3026 2.2 32.2 1.0 C05 A:K4D3026 2.4 32.2 1.0 O06 A:K4D3026 3.5 32.2 1.0 CE1 A:PHE895 3.5 13.8 1.0 CZ A:PHE895 4.0 13.8 1.0 C28 A:K4D3026 4.2 32.2 1.0 C07 A:K4D3026 4.3 32.2 1.0 CG1 A:ILE1457 4.3 24.9 1.0 CG2 A:ILE1456 4.4 21.9 1.0 CD1 A:PHE895 4.5 13.8 1.0 SG A:CYS899 4.7 13.2 1.0 CA A:ILE1457 4.7 24.9 1.0 CB A:PHE1461 4.7 36.2 1.0 N A:ILE1457 5.0 24.9 1.0

Fluorine binding site 2 out of 6 in the Cardiac Sodium Channel with Flecainide


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Cardiac Sodium Channel with Flecainide within 5.0Å range: probe atom residue distance (Å) B Occ A:F3026 b:32.2 occ:1.00 F03 A:K4D3026 0.0 32.2 1.0 C02 A:K4D3026 1.4 32.2 1.0 F04 A:K4D3026 2.2 32.2 1.0 F01 A:K4D3026 2.2 32.2 1.0 C05 A:K4D3026 2.4 32.2 1.0 O06 A:K4D3026 2.7 32.2 1.0 C07 A:K4D3026 2.8 32.2 1.0 C28 A:K4D3026 2.8 32.2 1.0 CB A:PHE1461 3.1 36.2 1.0 CD1 A:PHE1461 3.4 36.2 1.0 CG A:PHE1461 3.4 36.2 1.0 C08 A:K4D3026 3.8 32.2 1.0 C27 A:K4D3026 3.8 32.2 1.0 CA A:PHE1461 4.0 36.2 1.0 N A:PHE1461 4.1 36.2 1.0 CE1 A:PHE1461 4.4 36.2 1.0 CD2 A:PHE1461 4.5 36.2 1.0 C20 A:K4D3026 4.6 32.2 1.0 C09 A:K4D3026 4.6 32.2 1.0 O A:ILE1456 4.8 21.9 1.0 CG1 A:VAL933 4.9 32.3 1.0 CA A:ILE1457 4.9 24.9 1.0 C A:SER1460 5.0 30.7 1.0

Fluorine binding site 3 out of 6 in the Cardiac Sodium Channel with Flecainide


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Cardiac Sodium Channel with Flecainide within 5.0Å range: probe atom residue distance (Å) B Occ A:F3026 b:32.2 occ:1.00 F04 A:K4D3026 0.0 32.2 1.0 C02 A:K4D3026 1.3 32.2 1.0 F01 A:K4D3026 2.1 32.2 1.0 F03 A:K4D3026 2.2 32.2 1.0 C05 A:K4D3026 2.4 32.2 1.0 C28 A:K4D3026 2.7 32.2 1.0 O06 A:K4D3026 3.3 32.2 1.0 C07 A:K4D3026 3.4 32.2 1.0 C27 A:K4D3026 3.6 32.2 1.0 O A:LEU898 4.0 13.5 1.0 CG1 A:VAL933 4.0 32.3 1.0 C A:LEU898 4.3 13.5 1.0 CG2 A:VAL933 4.3 32.3 1.0 CB A:LEU898 4.4 13.5 1.0 N A:CYS899 4.5 13.2 1.0 CA A:CYS899 4.5 13.2 1.0 CD1 A:PHE1461 4.6 36.2 1.0 C08 A:K4D3026 4.7 32.2 1.0 CB A:VAL933 4.8 32.3 1.0 C20 A:K4D3026 4.8 32.2 1.0 SG A:CYS899 4.9 13.2 1.0

Fluorine binding site 4 out of 6 in the Cardiac Sodium Channel with Flecainide


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of Cardiac Sodium Channel with Flecainide within 5.0Å range: probe atom residue distance (Å) B Occ A:F3026 b:32.2 occ:1.00 F24 A:K4D3026 0.0 32.2 1.0 C23 A:K4D3026 1.4 32.2 1.0 F25 A:K4D3026 2.2 32.2 1.0 F26 A:K4D3026 2.2 32.2 1.0 C22 A:K4D3026 2.4 32.2 1.0 CD1 A:LEU934 2.9 33.9 1.0 CA A:LEU934 3.6 33.9 1.0 O21 A:K4D3026 3.6 32.2 1.0 CB A:LEU934 3.8 33.9 1.0 N A:LEU934 3.9 33.9 1.0 CG A:LEU934 4.0 33.9 1.0 CG1 A:VAL933 4.2 32.3 1.0 C A:VAL933 4.3 32.3 1.0 O A:VAL933 4.4 32.3 1.0 C20 A:K4D3026 4.6 32.2 1.0 CB A:PHE937 4.6 37.1 1.0 C27 A:K4D3026 4.6 32.2 1.0 O A:ASN930 4.7 25.8 1.0 CD2 A:LEU934 4.8 33.9 1.0 C A:LEU934 4.9 33.9 1.0 CG A:PHE937 4.9 37.1 1.0 CB A:VAL933 4.9 32.3 1.0

Fluorine binding site 5 out of 6 in the Cardiac Sodium Channel with Flecainide


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 5 of Cardiac Sodium Channel with Flecainide within 5.0Å range: probe atom residue distance (Å) B Occ A:F3026 b:32.2 occ:1.00 F25 A:K4D3026 0.0 32.2 1.0 C23 A:K4D3026 1.4 32.2 1.0 F26 A:K4D3026 2.2 32.2 1.0 F24 A:K4D3026 2.2 32.2 1.0 C22 A:K4D3026 2.4 32.2 1.0 O21 A:K4D3026 2.7 32.2 1.0 CD2 A:PHE937 3.1 37.1 1.0 CG A:PHE937 3.2 37.1 1.0 CB A:PHE937 3.3 37.1 1.0 C20 A:K4D3026 3.6 32.2 1.0 CE2 A:PHE937 3.8 37.1 1.0 CE1 A:PHE1461 3.9 36.2 1.0 CD1 A:PHE937 3.9 37.1 1.0 C27 A:K4D3026 3.9 32.2 1.0 CG1 A:VAL933 4.1 32.3 1.0 O A:VAL933 4.2 32.3 1.0 O11 A:K4D3026 4.3 32.2 1.0 CD1 A:PHE1461 4.3 36.2 1.0 CD1 A:LEU934 4.4 33.9 1.0 CZ A:PHE937 4.4 37.1 1.0 CE1 A:PHE937 4.5 37.1 1.0 CA A:LEU934 4.6 33.9 1.0 C09 A:K4D3026 4.6 32.2 1.0 C A:VAL933 4.7 32.3 1.0 CA A:PHE937 4.8 37.1 1.0 C10 A:K4D3026 4.9 32.2 1.0 N A:LEU934 4.9 33.9 1.0 CZ A:PHE1461 4.9 36.2 1.0

Fluorine binding site 6 out of 6 in the Cardiac Sodium Channel with Flecainide


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 6 of Cardiac Sodium Channel with Flecainide within 5.0Å range: probe atom residue distance (Å) B Occ A:F3026 b:32.2 occ:1.00 F26 A:K4D3026 0.0 32.2 1.0 C23 A:K4D3026 1.4 32.2 1.0 F25 A:K4D3026 2.2 32.2 1.0 F24 A:K4D3026 2.2 32.2 1.0 C22 A:K4D3026 2.4 32.2 1.0 O21 A:K4D3026 2.8 32.2 1.0 CD1 A:LEU934 3.8 33.9 1.0 C20 A:K4D3026 4.2 32.2 1.0 O11 A:K4D3026 4.4 32.2 1.0 CG A:PHE937 4.5 37.1 1.0 CD1 A:PHE937 4.5 37.1 1.0 CD2 A:PHE937 4.6 37.1 1.0 CD1 A:LEU410 4.7 35.2 1.0 CE1 A:PHE937 4.7 37.1 1.0 CE2 A:PHE937 4.8 37.1 1.0 CD2 A:LEU410 4.8 35.2 1.0 C27 A:K4D3026 4.9 32.2 1.0 CZ A:PHE937 4.9 37.1 1.0 CB A:PHE937 4.9 37.1 1.0 C10 A:K4D3026 4.9 32.2 1.0

D.Jiang, H.Shi, L.Tonggu, C.Yoshioka, N.Zheng, W.A.Catterall. Structure of the Cardiac Sodium Channel Cell(Cambridge,Mass.) 2019.
ISSN: ISSN 0092-8674
DOI: 10.1016/J.CELL.2019.11.041