Fluorine in PDB 6v3h: Structure of NPC1-Like Intracellular Cholesterol Transporter 1 (NPC1L1) in Complex with An Ezetimibe Analog

The binding sites of Fluorine atom in the Structure of NPC1-Like Intracellular Cholesterol Transporter 1 (NPC1L1) in Complex with An Ezetimibe Analog (pdb code 6v3h). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Structure of NPC1-Like Intracellular Cholesterol Transporter 1 (NPC1L1) in Complex with An Ezetimibe Analog, PDB code: 6v3h:

Fluorine binding site 1 out of 1 in the Structure of NPC1-Like Intracellular Cholesterol Transporter 1 (NPC1L1) in Complex with An Ezetimibe Analog


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Structure of NPC1-Like Intracellular Cholesterol Transporter 1 (NPC1L1) in Complex with An Ezetimibe Analog within 5.0Å range: probe atom residue distance (Å) B Occ A:F1421 b:37.7 occ:1.00 F01 A:QO11421 0.0 37.7 1.0 C01 A:QO11421 1.4 37.7 1.0 C02 A:QO11421 2.4 37.7 1.0 C04 A:QO11421 2.4 37.7 1.0 CG A:PRO474 3.2 40.7 1.0 CB A:ALA548 3.3 36.1 1.0 CB A:PRO474 3.4 40.7 1.0 C03 A:QO11421 3.6 37.7 1.0 C05 A:QO11421 3.6 37.7 1.0 CB A:ALA1031 3.8 34.3 1.0 CA A:ALA548 4.0 36.1 1.0 O A:GLY547 4.1 37.6 1.0 C06 A:QO11421 4.1 37.7 1.0 CE2 A:TYR546 4.2 37.6 1.0 CG A:LEU475 4.2 44.3 1.0 C A:GLY547 4.2 37.6 1.0 N A:ALA548 4.3 36.1 1.0 CD2 A:TYR546 4.3 37.6 1.0 O A:TYR546 4.5 37.6 1.0 N A:LEU475 4.6 44.3 1.0 CD A:PRO474 4.6 40.7 1.0 CA A:PRO474 4.6 40.7 1.0 C A:PRO474 4.7 40.7 1.0 CD2 A:LEU475 4.9 44.3 1.0 CD1 A:LEU475 4.9 44.3 1.0 CB A:LEU475 4.9 44.3 1.0

C.S.Huang, X.Yu, P.Fordstrom, K.Choi, B.C.Chung, S.H.Roh, W.Chiu, M.Zhou, X.Min, Z.Wang. Cryo-Em Structures of NPC1L1 Reveal Mechanisms of Cholesterol Transport and Ezetimibe Inhibition Sci Adv V. 6 B1989 2020.
ISSN: ESSN 2375-2548
DOI: 10.1126/SCIADV.ABB1989