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Fluorine in PDB 6vn3: USP7 in Complex with Ligand Compound 23Enzymatic activity of USP7 in Complex with Ligand Compound 23
All present enzymatic activity of USP7 in Complex with Ligand Compound 23:
3.4.19.12; Protein crystallography data
The structure of USP7 in Complex with Ligand Compound 23, PDB code: 6vn3
was solved by
P.R.Leger,
D.J.Wustrow,
D.X.Hu,
S.Krapp,
K.Maskos,
M.Blaesse,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 6vn3:
The structure of USP7 in Complex with Ligand Compound 23 also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the USP7 in Complex with Ligand Compound 23
(pdb code 6vn3). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the USP7 in Complex with Ligand Compound 23, PDB code: 6vn3: Jump to Fluorine binding site number: 1; 2; Fluorine binding site 1 out of 2 in 6vn3Go back to Fluorine Binding Sites List in 6vn3
Fluorine binding site 1 out
of 2 in the USP7 in Complex with Ligand Compound 23
Mono view Stereo pair view
Fluorine binding site 2 out of 2 in 6vn3Go back to Fluorine Binding Sites List in 6vn3
Fluorine binding site 2 out
of 2 in the USP7 in Complex with Ligand Compound 23
Mono view Stereo pair view
Reference:
P.R.Leger,
D.X.Hu,
B.Biannic,
M.Bui,
X.Han,
E.Karbarz,
J.Maung,
A.Okano,
M.Osipov,
G.M.Shibuya,
K.Young,
C.Higgs,
B.Abraham,
D.Bradford,
C.Cho,
C.Colas,
S.Jacobson,
Y.M.Ohol,
D.Pookot,
P.Rana,
J.Sanchez,
N.Shah,
M.Sun,
S.Wong,
D.G.Brockstedt,
P.D.Kassner,
J.B.Schwarz,
D.J.Wustrow.
Discovery of Potent, Selective, and Orally Bioavailable Inhibitors of USP7 with in Vivo Anti-Tumor Activity. J.Med.Chem. 2020.
Page generated: Sun Dec 13 13:24:22 2020
ISSN: ISSN 0022-2623 PubMed: 32302140 DOI: 10.1021/ACS.JMEDCHEM.0C00245 |
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