Fluorine in PDB 6vqr: Cryoem Structure of the Pffnt-Inhibitor Complex

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>>> Page 1 <<< Page 2, Binding sites: 11 - 20; Page 3, Binding sites: 21 - 25;

Binding sites:

The binding sites of Fluorine atom in the Cryoem Structure of the Pffnt-Inhibitor Complex (pdb code 6vqr). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 25 binding sites of Fluorine where determined in the Cryoem Structure of the Pffnt-Inhibitor Complex, PDB code: 6vqr:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Fluorine binding site 1 out of 25 in the Cryoem Structure of the Pffnt-Inhibitor Complex


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Cryoem Structure of the Pffnt-Inhibitor Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:F401 b:80.6 occ:1.00 F01 A:R7M401 0.0 80.6 1.0 C12 A:R7M401 1.4 80.6 1.0 F02 A:R7M401 2.2 80.6 1.0 C10 A:R7M401 2.2 80.6 1.0 C16 A:R7M401 2.4 80.6 1.0 O06 A:R7M401 2.6 80.6 1.0 F03 A:R7M401 2.6 80.6 1.0 CA A:PHE94 2.7 79.3 1.0 O07 A:R7M401 2.7 80.6 1.0 N A:PHE94 2.8 79.3 1.0 CB A:PHE94 2.9 79.3 1.0 F05 A:R7M401 2.9 80.6 1.0 CD2 A:PHE94 3.2 79.3 1.0 CG A:PHE94 3.2 79.3 1.0 C A:ALA93 3.5 76.7 1.0 F04 A:R7M401 3.5 80.6 1.0 C11 A:R7M401 3.7 80.6 1.0 O A:ALA93 3.8 76.7 1.0 C15 A:R7M401 4.0 80.6 1.0 C A:PHE94 4.1 79.3 1.0 CB A:ALA93 4.2 76.7 1.0 CE2 A:PHE94 4.2 79.3 1.0 CD1 A:PHE94 4.3 79.3 1.0 CA A:ALA93 4.4 76.7 1.0 O A:PHE94 4.6 79.3 1.0 CG2 A:VAL220 4.6 74.5 1.0 C13 A:R7M401 4.7 80.6 1.0 C14 A:R7M401 4.8 80.6 1.0 CD1 A:ILE97 4.9 78.9 1.0

Fluorine binding site 2 out of 25 in the Cryoem Structure of the Pffnt-Inhibitor Complex


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Cryoem Structure of the Pffnt-Inhibitor Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:F401 b:80.6 occ:1.00 F02 A:R7M401 0.0 80.6 1.0 C12 A:R7M401 1.4 80.6 1.0 C10 A:R7M401 2.2 80.6 1.0 F01 A:R7M401 2.2 80.6 1.0 C16 A:R7M401 2.4 80.6 1.0 CD2 A:PHE94 2.5 79.3 1.0 F04 A:R7M401 2.6 80.6 1.0 C11 A:R7M401 2.6 80.6 1.0 O06 A:R7M401 2.8 80.6 1.0 F03 A:R7M401 2.9 80.6 1.0 CE2 A:PHE94 3.1 79.3 1.0 O07 A:R7M401 3.4 80.6 1.0 CG A:PHE94 3.5 79.3 1.0 F05 A:R7M401 3.5 80.6 1.0 CG2 A:VAL220 3.8 74.5 1.0 CB A:PHE94 3.8 79.3 1.0 C15 A:R7M401 3.9 80.6 1.0 C13 A:R7M401 3.9 80.6 1.0 C14 A:R7M401 4.2 80.6 1.0 CG1 A:VAL196 4.3 73.1 1.0 CZ A:PHE94 4.3 79.3 1.0 CA A:PHE94 4.3 79.3 1.0 CD1 A:PHE94 4.6 79.3 1.0 N A:PHE94 4.8 79.3 1.0 O08 A:R7M401 4.8 80.6 1.0 CG2 A:VAL196 4.9 73.1 1.0 CE1 A:PHE94 5.0 79.3 1.0

Fluorine binding site 3 out of 25 in the Cryoem Structure of the Pffnt-Inhibitor Complex


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Cryoem Structure of the Pffnt-Inhibitor Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:F401 b:80.6 occ:1.00 F03 A:R7M401 0.0 80.6 1.0 C16 A:R7M401 1.4 80.6 1.0 F04 A:R7M401 2.2 80.6 1.0 F05 A:R7M401 2.2 80.6 1.0 C12 A:R7M401 2.4 80.6 1.0 F01 A:R7M401 2.6 80.6 1.0 F02 A:R7M401 2.9 80.6 1.0 CE1 A:PHE90 3.3 73.0 1.0 C10 A:R7M401 3.5 80.6 1.0 O07 A:R7M401 3.8 80.6 1.0 CG1 A:VAL220 3.8 74.5 1.0 CD1 A:PHE90 3.9 73.0 1.0 CG2 A:VAL220 4.0 74.5 1.0 C11 A:R7M401 4.2 80.6 1.0 CB A:ALA93 4.2 76.7 1.0 CZ A:PHE90 4.3 73.0 1.0 N A:PHE94 4.5 79.3 1.0 CB A:VAL220 4.6 74.5 1.0 CE2 A:PHE223 4.7 72.3 1.0 O06 A:R7M401 4.7 80.6 1.0 CB A:PHE94 4.9 79.3 1.0 CD2 A:PHE94 4.9 79.3 1.0 CE1 A:HIS230 4.9 71.2 1.0 CA A:PHE94 4.9 79.3 1.0 C A:ALA93 4.9 76.7 1.0

Fluorine binding site 4 out of 25 in the Cryoem Structure of the Pffnt-Inhibitor Complex


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of Cryoem Structure of the Pffnt-Inhibitor Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:F401 b:80.6 occ:1.00 F04 A:R7M401 0.0 80.6 1.0 C16 A:R7M401 1.4 80.6 1.0 F03 A:R7M401 2.2 80.6 1.0 F05 A:R7M401 2.2 80.6 1.0 C12 A:R7M401 2.4 80.6 1.0 F02 A:R7M401 2.6 80.6 1.0 C11 A:R7M401 2.7 80.6 1.0 C10 A:R7M401 2.9 80.6 1.0 O07 A:R7M401 3.3 80.6 1.0 CE1 A:HIS230 3.3 71.2 1.0 F01 A:R7M401 3.5 80.6 1.0 ND1 A:HIS230 3.8 71.2 1.0 NE2 A:HIS230 4.0 71.2 1.0 C13 A:R7M401 4.0 80.6 1.0 CG2 A:VAL196 4.1 73.1 1.0 CG1 A:VAL196 4.3 73.1 1.0 O06 A:R7M401 4.4 80.6 1.0 O08 A:R7M401 4.5 80.6 1.0 CE2 A:PHE223 4.6 72.3 1.0 CG A:HIS230 4.7 71.2 1.0 CD2 A:LEU104 4.7 75.4 1.0 CD2 A:HIS230 4.8 71.2 1.0 CE1 A:PHE90 4.8 73.0 1.0 CB A:VAL196 4.8 73.1 1.0 C14 A:R7M401 4.9 80.6 1.0 CZ A:PHE223 5.0 72.3 1.0

Fluorine binding site 5 out of 25 in the Cryoem Structure of the Pffnt-Inhibitor Complex


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 5 of Cryoem Structure of the Pffnt-Inhibitor Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:F401 b:80.6 occ:1.00 F05 A:R7M401 0.0 80.6 1.0 C16 A:R7M401 1.4 80.6 1.0 O07 A:R7M401 2.1 80.6 1.0 F03 A:R7M401 2.2 80.6 1.0 F04 A:R7M401 2.2 80.6 1.0 C12 A:R7M401 2.4 80.6 1.0 C10 A:R7M401 2.6 80.6 1.0 F01 A:R7M401 2.9 80.6 1.0 C11 A:R7M401 3.3 80.6 1.0 F02 A:R7M401 3.5 80.6 1.0 CE1 A:HIS230 3.7 71.2 1.0 O06 A:R7M401 4.1 80.6 1.0 CD2 A:LEU104 4.1 75.4 1.0 CE1 A:PHE90 4.2 73.0 1.0 CB A:ALA93 4.3 76.7 1.0 ND1 A:HIS230 4.4 71.2 1.0 CG2 A:VAL54 4.4 72.8 1.0 C13 A:R7M401 4.4 80.6 1.0 CZ A:PHE90 4.7 73.0 1.0 NE2 A:HIS230 4.7 71.2 1.0 CB A:VAL54 4.8 72.8 1.0 CD1 A:ILE97 4.8 78.9 1.0 CD1 A:LEU104 4.9 75.4 1.0

Fluorine binding site 6 out of 25 in the Cryoem Structure of the Pffnt-Inhibitor Complex


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 6 of Cryoem Structure of the Pffnt-Inhibitor Complex within 5.0Å range: probe atom residue distance (Å) B Occ B:F401 b:75.6 occ:1.00 F01 B:R7M401 0.0 75.6 1.0 C12 B:R7M401 1.4 75.6 1.0 F02 B:R7M401 2.2 75.6 1.0 C10 B:R7M401 2.2 75.6 1.0 C16 B:R7M401 2.4 75.6 1.0 O06 B:R7M401 2.6 75.6 1.0 F03 B:R7M401 2.6 75.6 1.0 CB B:PHE94 2.7 76.7 1.0 O07 B:R7M401 2.7 75.6 1.0 F05 B:R7M401 2.9 75.6 1.0 CA B:PHE94 3.0 76.7 1.0 N B:PHE94 3.0 76.7 1.0 CD2 B:PHE94 3.1 76.7 1.0 CG B:PHE94 3.3 76.7 1.0 F04 B:R7M401 3.5 75.6 1.0 C11 B:R7M401 3.7 75.6 1.0 C B:ALA93 4.0 74.3 1.0 C15 B:R7M401 4.0 75.6 1.0 CG2 B:VAL220 4.1 72.6 1.0 CE2 B:PHE94 4.4 76.7 1.0 CB B:ALA93 4.5 74.3 1.0 C B:PHE94 4.5 76.7 1.0 O B:ALA93 4.6 74.3 1.0 CD1 B:PHE94 4.7 76.7 1.0 C13 B:R7M401 4.7 75.6 1.0 CA B:ALA93 4.7 74.3 1.0 C14 B:R7M401 4.7 75.6 1.0 CG1 B:VAL220 4.8 72.6 1.0 CG1 B:VAL216 5.0 77.5 1.0

Fluorine binding site 7 out of 25 in the Cryoem Structure of the Pffnt-Inhibitor Complex


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 7 of Cryoem Structure of the Pffnt-Inhibitor Complex within 5.0Å range: probe atom residue distance (Å) B Occ B:F401 b:75.6 occ:1.00 F02 B:R7M401 0.0 75.6 1.0 C12 B:R7M401 1.4 75.6 1.0 F01 B:R7M401 2.2 75.6 1.0 C10 B:R7M401 2.2 75.6 1.0 C16 B:R7M401 2.4 75.6 1.0 F04 B:R7M401 2.6 75.6 1.0 C11 B:R7M401 2.7 75.6 1.0 O06 B:R7M401 2.8 75.6 1.0 F03 B:R7M401 2.9 75.6 1.0 O07 B:R7M401 3.4 75.6 1.0 CD2 B:PHE94 3.5 76.7 1.0 F05 B:R7M401 3.5 75.6 1.0 C13 B:R7M401 3.7 75.6 1.0 CG1 B:VAL196 3.9 73.5 1.0 C15 B:R7M401 3.9 75.6 1.0 CG2 B:VAL220 4.1 72.6 1.0 C14 B:R7M401 4.1 75.6 1.0 CG2 B:VAL196 4.3 73.5 1.0 CE2 B:PHE94 4.3 76.7 1.0 CB B:PHE94 4.4 76.7 1.0 CG B:PHE94 4.4 76.7 1.0 O08 B:R7M401 4.5 75.6 1.0 CE2 B:PHE223 4.5 72.5 1.0 CB B:VAL196 4.6 73.5 1.0 NE2 B:HIS230 4.7 66.1 1.0 CG1 B:VAL220 4.8 72.6 1.0 CD2 B:HIS230 4.9 66.1 1.0

Fluorine binding site 8 out of 25 in the Cryoem Structure of the Pffnt-Inhibitor Complex


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 8 of Cryoem Structure of the Pffnt-Inhibitor Complex within 5.0Å range: probe atom residue distance (Å) B Occ B:F401 b:75.6 occ:1.00 F03 B:R7M401 0.0 75.6 1.0 C16 B:R7M401 1.4 75.6 1.0 F04 B:R7M401 2.2 75.6 1.0 F05 B:R7M401 2.2 75.6 1.0 C12 B:R7M401 2.4 75.6 1.0 F01 B:R7M401 2.6 75.6 1.0 CE1 B:PHE90 2.9 69.6 1.0 F02 B:R7M401 2.9 75.6 1.0 CD1 B:PHE90 3.5 69.6 1.0 C10 B:R7M401 3.5 75.6 1.0 CG1 B:VAL220 3.7 72.6 1.0 O07 B:R7M401 3.8 75.6 1.0 CZ B:PHE90 4.0 69.6 1.0 CE2 B:PHE223 4.1 72.5 1.0 C11 B:R7M401 4.2 75.6 1.0 CB B:ALA93 4.3 74.3 1.0 CZ B:PHE223 4.4 72.5 1.0 CG2 B:VAL220 4.4 72.6 1.0 N B:PHE94 4.7 76.7 1.0 CB B:VAL220 4.7 72.6 1.0 O06 B:R7M401 4.7 75.6 1.0 CG B:PHE90 4.8 69.6 1.0 CD2 B:HIS230 4.9 66.1 1.0 CG2 B:VAL54 4.9 69.8 1.0 NE2 B:HIS230 4.9 66.1 1.0

Fluorine binding site 9 out of 25 in the Cryoem Structure of the Pffnt-Inhibitor Complex


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 9 of Cryoem Structure of the Pffnt-Inhibitor Complex within 5.0Å range: probe atom residue distance (Å) B Occ B:F401 b:75.6 occ:1.00 F04 B:R7M401 0.0 75.6 1.0 C16 B:R7M401 1.4 75.6 1.0 F05 B:R7M401 2.2 75.6 1.0 F03 B:R7M401 2.2 75.6 1.0 C12 B:R7M401 2.4 75.6 1.0 F02 B:R7M401 2.6 75.6 1.0 C11 B:R7M401 2.7 75.6 1.0 NE2 B:HIS230 2.8 66.1 1.0 C10 B:R7M401 2.9 75.6 1.0 CD2 B:HIS230 3.0 66.1 1.0 O07 B:R7M401 3.4 75.6 1.0 F01 B:R7M401 3.5 75.6 1.0 CE1 B:HIS230 3.8 66.1 1.0 C13 B:R7M401 4.1 75.6 1.0 CG B:HIS230 4.1 66.1 1.0 CE1 B:PHE90 4.3 69.6 1.0 CD1 B:LEU104 4.3 69.9 1.0 CZ B:PHE223 4.3 72.5 1.0 O06 B:R7M401 4.4 75.6 1.0 CE2 B:PHE223 4.4 72.5 1.0 ND1 B:HIS230 4.5 66.1 1.0 O08 B:R7M401 4.6 75.6 1.0 CG2 B:VAL54 4.6 69.8 1.0 CG2 B:VAL196 4.8 73.5 1.0 CZ B:PHE90 4.9 69.6 1.0 C14 B:R7M401 4.9 75.6 1.0

Fluorine binding site 10 out of 25 in the Cryoem Structure of the Pffnt-Inhibitor Complex


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 10 of Cryoem Structure of the Pffnt-Inhibitor Complex within 5.0Å range: probe atom residue distance (Å) B Occ B:F401 b:75.6 occ:1.00 F05 B:R7M401 0.0 75.6 1.0 C16 B:R7M401 1.4 75.6 1.0 O07 B:R7M401 2.1 75.6 1.0 F04 B:R7M401 2.2 75.6 1.0 F03 B:R7M401 2.2 75.6 1.0 C12 B:R7M401 2.4 75.6 1.0 C10 B:R7M401 2.6 75.6 1.0 F01 B:R7M401 2.9 75.6 1.0 C11 B:R7M401 3.3 75.6 1.0 CG2 B:VAL54 3.5 69.8 1.0 F02 B:R7M401 3.5 75.6 1.0 CB B:ALA93 3.6 74.3 1.0 CE1 B:PHE90 3.9 69.6 1.0 O06 B:R7M401 4.1 75.6 1.0 CD1 B:LEU104 4.1 69.9 1.0 CB B:VAL54 4.3 69.8 1.0 N B:PHE94 4.4 76.7 1.0 CD1 B:ILE97 4.4 77.0 1.0 C B:ALA93 4.4 74.3 1.0 CZ B:PHE90 4.5 69.6 1.0 NE2 B:HIS230 4.6 66.1 1.0 C13 B:R7M401 4.6 75.6 1.0 CA B:ALA93 4.6 74.3 1.0 CD1 B:PHE90 4.9 69.6 1.0 O B:ALA93 4.9 74.3 1.0 CA B:PHE94 4.9 76.7 1.0 C15 B:R7M401 5.0 75.6 1.0

M.Lyu, C.C.Su, J.W.Kazura, E.W.Yu. Structural Basis of Transport and Inhibition of the Plasmodium Falciparum Transporter Pffnt. Embo Rep. 51628 2021.
ISSN: ESSN 1469-3178
PubMed: 33471955
DOI: 10.15252/EMBR.202051628