Fluorine in PDB 6w4y: Structure of Full-Length Human Lambda-6A Light Chain Jto in Complex with Hydantoin Stabilizer

The structure of Structure of Full-Length Human Lambda-6A Light Chain Jto in Complex with Hydantoin Stabilizer, PDB code: 6w4y was solved by N.L.Yan, G.J.Morgan, J.W.Kelly, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	44.65 / 1.91
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	63.713, 82.341, 95.912, 90.00, 90.00, 90.00
R / Rfree (%)	18.1 / 23.2

The binding sites of Fluorine atom in the Structure of Full-Length Human Lambda-6A Light Chain Jto in Complex with Hydantoin Stabilizer (pdb code 6w4y). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the Structure of Full-Length Human Lambda-6A Light Chain Jto in Complex with Hydantoin Stabilizer, PDB code: 6w4y:
Jump to Fluorine binding site number: 1; 2; 3;

Fluorine binding site 1 out of 3 in the Structure of Full-Length Human Lambda-6A Light Chain Jto in Complex with Hydantoin Stabilizer


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Structure of Full-Length Human Lambda-6A Light Chain Jto in Complex with Hydantoin Stabilizer within 5.0Å range: probe atom residue distance (Å) B Occ A:F301 b:43.1 occ:1.00 F2 A:7ZW301 0.0 43.1 1.0 C13 A:7ZW301 1.3 39.0 1.0 F A:7ZW301 2.1 41.4 1.0 F1 A:7ZW301 2.2 41.1 1.0 C12 A:7ZW301 2.3 36.2 1.0 C11 A:7ZW301 3.1 31.2 1.0 C14 A:7ZW301 3.3 33.8 1.0 CD2 A:TYR36 3.3 24.0 1.0 CB A:TYR36 3.5 23.1 1.0 CG A:TYR36 3.5 22.9 1.0 CE2 A:PHE98 3.7 39.3 1.0 CZ B:PHE98 4.0 21.6 1.0 CB A:PRO44 4.2 26.2 1.0 CE2 A:TYR36 4.2 25.2 1.0 CE2 B:PHE98 4.2 22.8 1.0 C10 A:7ZW301 4.3 32.3 1.0 CD2 A:PHE98 4.3 36.0 1.0 CG A:PRO44 4.3 26.7 1.0 CB A:TYR87 4.4 24.0 1.0 CD2 A:TYR87 4.4 25.2 1.0 C15 A:7ZW301 4.5 32.5 1.0 CD1 A:TYR36 4.5 23.5 1.0 CG A:TYR87 4.6 24.1 1.0 CZ A:PHE98 4.7 37.6 1.0 C9 A:7ZW301 4.9 34.5 1.0 CZ A:TYR36 5.0 24.3 1.0 CE1 B:PHE98 5.0 21.8 1.0 CA A:TYR36 5.0 23.0 1.0

Fluorine binding site 2 out of 3 in the Structure of Full-Length Human Lambda-6A Light Chain Jto in Complex with Hydantoin Stabilizer


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Structure of Full-Length Human Lambda-6A Light Chain Jto in Complex with Hydantoin Stabilizer within 5.0Å range: probe atom residue distance (Å) B Occ A:F301 b:41.4 occ:1.00 F A:7ZW301 0.0 41.4 1.0 C13 A:7ZW301 1.4 39.0 1.0 F2 A:7ZW301 2.1 43.1 1.0 F1 A:7ZW301 2.2 41.1 1.0 C12 A:7ZW301 2.4 36.2 1.0 C11 A:7ZW301 2.9 31.2 1.0 CG A:PRO44 3.3 26.7 1.0 CG B:PRO44 3.6 35.0 1.0 C14 A:7ZW301 3.6 33.8 1.0 CB A:PRO44 3.7 26.2 1.0 CD2 A:TYR87 3.8 25.2 1.0 CE2 A:TYR87 4.0 25.7 1.0 C10 A:7ZW301 4.2 32.3 1.0 CD B:PRO44 4.3 34.1 1.0 CG A:TYR87 4.4 24.1 1.0 OE1 A:GLN38 4.4 27.2 1.0 CB B:PRO44 4.6 32.8 1.0 CB A:TYR36 4.7 23.1 1.0 CD A:PRO44 4.8 24.8 1.0 CZ A:TYR87 4.8 25.6 1.0 C15 A:7ZW301 4.8 32.5 1.0 CD A:GLN38 4.8 28.2 1.0 CB A:TYR87 4.9 24.0 1.0 CB A:GLN38 4.9 26.2 1.0 CA A:PRO44 4.9 27.0 1.0

Fluorine binding site 3 out of 3 in the Structure of Full-Length Human Lambda-6A Light Chain Jto in Complex with Hydantoin Stabilizer


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Structure of Full-Length Human Lambda-6A Light Chain Jto in Complex with Hydantoin Stabilizer within 5.0Å range: probe atom residue distance (Å) B Occ A:F301 b:41.1 occ:1.00 F1 A:7ZW301 0.0 41.1 1.0 C13 A:7ZW301 1.3 39.0 1.0 F A:7ZW301 2.2 41.4 1.0 F2 A:7ZW301 2.2 43.1 1.0 C12 A:7ZW301 2.4 36.2 1.0 C14 A:7ZW301 2.8 33.8 1.0 CG A:PRO44 3.2 26.7 1.0 CE2 B:PHE98 3.4 22.8 1.0 C11 A:7ZW301 3.6 31.2 1.0 CB A:PRO44 3.7 26.2 1.0 CZ B:PHE98 3.9 21.6 1.0 CD2 B:PHE98 4.2 22.3 1.0 C15 A:7ZW301 4.2 32.5 1.0 CD2 B:TYR36 4.3 25.6 1.0 CG B:PRO44 4.3 35.0 1.0 CG B:TYR36 4.6 23.6 1.0 CD A:PRO44 4.6 24.8 1.0 CE2 B:TYR36 4.6 24.8 1.0 CB B:PRO44 4.6 32.8 1.0 CE2 A:PHE98 4.7 39.3 1.0 C10 A:7ZW301 4.8 32.3 1.0 CB B:TYR36 5.0 22.6 1.0 CE1 B:PHE98 5.0 21.8 1.0

N.L.Yan, D.Santos-Martins, E.Rennella, B.B.Sanchez, J.S.Chen, L.E.Kay, I.A.Wilson, G.J.Morgan, S.Forli, J.W.Kelly. Structural Basis For the Stabilization of Amyloidogenic Immunoglobulin Light Chains By Hydantoins. Bioorg.Med.Chem.Lett. V. 30 27356 2020.
ISSN: ESSN 1464-3405
PubMed: 32631553
DOI: 10.1016/J.BMCL.2020.127356