Fluorine in PDB 6x14: Inward-Facing State of the Glutamate Transporter Homologue Gltph in Complex with Tfb-Tboa

The binding sites of Fluorine atom in the Inward-Facing State of the Glutamate Transporter Homologue Gltph in Complex with Tfb-Tboa (pdb code 6x14). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 9 binding sites of Fluorine where determined in the Inward-Facing State of the Glutamate Transporter Homologue Gltph in Complex with Tfb-Tboa, PDB code: 6x14:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9;

Fluorine binding site 1 out of 9 in the Inward-Facing State of the Glutamate Transporter Homologue Gltph in Complex with Tfb-Tboa


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Inward-Facing State of the Glutamate Transporter Homologue Gltph in Complex with Tfb-Tboa within 5.0Å range: probe atom residue distance (Å) B Occ A:F501 b:52.0 occ:1.00 F2 A:7O9501 0.0 52.0 1.0 C13 A:7O9501 1.4 52.0 1.0 F A:7O9501 2.2 52.0 1.0 F1 A:7O9501 2.2 52.0 1.0 C12 A:7O9501 2.3 52.0 1.0 C14 A:7O9501 2.8 52.0 1.0 CZ A:PHE50 3.1 35.6 1.0 CD1 A:ILE16 3.3 48.0 1.0 C11 A:7O9501 3.5 52.0 1.0 CE2 A:PHE50 3.7 35.6 1.0 CB A:ALA205 3.9 40.3 1.0 C15 A:7O9501 4.1 52.0 1.0 CE1 A:PHE50 4.2 35.6 1.0 SD A:MET202 4.5 41.5 1.0 C10 A:7O9501 4.6 52.0 1.0 CG1 A:ILE16 4.7 48.0 1.0 CD1 A:LEU54 4.7 33.2 1.0 CD2 A:LEU387 4.7 42.9 1.0 CE A:MET202 4.8 41.5 1.0 C9 A:7O9501 4.9 52.0 1.0

Fluorine binding site 2 out of 9 in the Inward-Facing State of the Glutamate Transporter Homologue Gltph in Complex with Tfb-Tboa


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Inward-Facing State of the Glutamate Transporter Homologue Gltph in Complex with Tfb-Tboa within 5.0Å range: probe atom residue distance (Å) B Occ A:F501 b:52.0 occ:1.00 F A:7O9501 0.0 52.0 1.0 C13 A:7O9501 1.4 52.0 1.0 F2 A:7O9501 2.2 52.0 1.0 F1 A:7O9501 2.2 52.0 1.0 C12 A:7O9501 2.4 52.0 1.0 C11 A:7O9501 2.7 52.0 1.0 CD1 A:ILE16 3.3 48.0 1.0 CD2 A:LEU387 3.3 42.9 1.0 C14 A:7O9501 3.6 52.0 1.0 CG A:LEU387 3.9 42.9 1.0 C10 A:7O9501 4.1 52.0 1.0 CG1 A:ILE16 4.3 48.0 1.0 CG2 A:VAL209 4.4 39.6 1.0 C15 A:7O9501 4.7 52.0 1.0 CZ A:PHE50 4.7 35.6 1.0 CE2 A:PHE50 4.8 35.6 1.0 CB A:VAL209 4.8 39.6 1.0 CB A:LEU387 4.9 42.9 1.0 C9 A:7O9501 4.9 52.0 1.0 CD1 A:LEU387 5.0 42.9 1.0

Fluorine binding site 3 out of 9 in the Inward-Facing State of the Glutamate Transporter Homologue Gltph in Complex with Tfb-Tboa


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Inward-Facing State of the Glutamate Transporter Homologue Gltph in Complex with Tfb-Tboa within 5.0Å range: probe atom residue distance (Å) B Occ A:F501 b:52.0 occ:1.00 F1 A:7O9501 0.0 52.0 1.0 C13 A:7O9501 1.4 52.0 1.0 F2 A:7O9501 2.2 52.0 1.0 F A:7O9501 2.2 52.0 1.0 C12 A:7O9501 2.4 52.0 1.0 C14 A:7O9501 3.0 52.0 1.0 C11 A:7O9501 3.3 52.0 1.0 CD2 A:LEU387 3.3 42.9 1.0 CB A:ALA360 3.9 39.4 1.0 CD1 A:LEU54 4.0 33.2 1.0 CG A:LEU387 4.1 42.9 1.0 CZ A:PHE50 4.1 35.6 1.0 CE2 A:PHE50 4.2 35.6 1.0 OH A:TYR383 4.2 44.6 1.0 C15 A:7O9501 4.3 52.0 1.0 CD1 A:LEU387 4.5 42.9 1.0 C10 A:7O9501 4.5 52.0 1.0 CA A:ALA360 4.9 39.4 1.0 C9 A:7O9501 4.9 52.0 1.0 CZ A:TYR383 5.0 44.6 1.0

Fluorine binding site 4 out of 9 in the Inward-Facing State of the Glutamate Transporter Homologue Gltph in Complex with Tfb-Tboa


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of Inward-Facing State of the Glutamate Transporter Homologue Gltph in Complex with Tfb-Tboa within 5.0Å range: probe atom residue distance (Å) B Occ B:F501 b:52.0 occ:1.00 F2 B:7O9501 0.0 52.0 1.0 C13 B:7O9501 1.4 52.0 1.0 F B:7O9501 2.2 52.0 1.0 F1 B:7O9501 2.2 52.0 1.0 C12 B:7O9501 2.3 52.0 1.0 C14 B:7O9501 2.8 52.0 1.0 CZ B:PHE50 3.1 35.6 1.0 CD1 B:ILE16 3.3 48.0 1.0 C11 B:7O9501 3.5 52.0 1.0 CE2 B:PHE50 3.7 35.6 1.0 CB B:ALA205 3.9 40.3 1.0 C15 B:7O9501 4.1 52.0 1.0 CE1 B:PHE50 4.2 35.6 1.0 SD B:MET202 4.5 41.5 1.0 C10 B:7O9501 4.6 52.0 1.0 CG1 B:ILE16 4.7 48.0 1.0 CD1 B:LEU54 4.7 33.2 1.0 CD2 B:LEU387 4.7 42.9 1.0 CE B:MET202 4.8 41.5 1.0 C9 B:7O9501 4.9 52.0 1.0

Fluorine binding site 5 out of 9 in the Inward-Facing State of the Glutamate Transporter Homologue Gltph in Complex with Tfb-Tboa


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 5 of Inward-Facing State of the Glutamate Transporter Homologue Gltph in Complex with Tfb-Tboa within 5.0Å range: probe atom residue distance (Å) B Occ B:F501 b:52.0 occ:1.00 F B:7O9501 0.0 52.0 1.0 C13 B:7O9501 1.4 52.0 1.0 F2 B:7O9501 2.2 52.0 1.0 F1 B:7O9501 2.2 52.0 1.0 C12 B:7O9501 2.4 52.0 1.0 C11 B:7O9501 2.7 52.0 1.0 CD1 B:ILE16 3.3 48.0 1.0 CD2 B:LEU387 3.3 42.9 1.0 C14 B:7O9501 3.6 52.0 1.0 CG B:LEU387 3.9 42.9 1.0 C10 B:7O9501 4.1 52.0 1.0 CG1 B:ILE16 4.3 48.0 1.0 CG2 B:VAL209 4.4 39.6 1.0 C15 B:7O9501 4.7 52.0 1.0 CZ B:PHE50 4.7 35.6 1.0 CE2 B:PHE50 4.8 35.6 1.0 CB B:VAL209 4.8 39.6 1.0 CB B:LEU387 4.9 42.9 1.0 C9 B:7O9501 4.9 52.0 1.0 CD1 B:LEU387 5.0 42.9 1.0

Fluorine binding site 6 out of 9 in the Inward-Facing State of the Glutamate Transporter Homologue Gltph in Complex with Tfb-Tboa


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 6 of Inward-Facing State of the Glutamate Transporter Homologue Gltph in Complex with Tfb-Tboa within 5.0Å range: probe atom residue distance (Å) B Occ B:F501 b:52.0 occ:1.00 F1 B:7O9501 0.0 52.0 1.0 C13 B:7O9501 1.4 52.0 1.0 F2 B:7O9501 2.2 52.0 1.0 F B:7O9501 2.2 52.0 1.0 C12 B:7O9501 2.4 52.0 1.0 C14 B:7O9501 3.0 52.0 1.0 C11 B:7O9501 3.3 52.0 1.0 CD2 B:LEU387 3.3 42.9 1.0 CB B:ALA360 3.9 39.4 1.0 CD1 B:LEU54 4.0 33.2 1.0 CG B:LEU387 4.1 42.9 1.0 CZ B:PHE50 4.1 35.6 1.0 CE2 B:PHE50 4.2 35.6 1.0 OH B:TYR383 4.2 44.6 1.0 C15 B:7O9501 4.3 52.0 1.0 CD1 B:LEU387 4.5 42.9 1.0 C10 B:7O9501 4.5 52.0 1.0 CA B:ALA360 4.9 39.4 1.0 C9 B:7O9501 4.9 52.0 1.0 CZ B:TYR383 5.0 44.6 1.0

Fluorine binding site 7 out of 9 in the Inward-Facing State of the Glutamate Transporter Homologue Gltph in Complex with Tfb-Tboa


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 7 of Inward-Facing State of the Glutamate Transporter Homologue Gltph in Complex with Tfb-Tboa within 5.0Å range: probe atom residue distance (Å) B Occ C:F501 b:52.0 occ:1.00 F2 C:7O9501 0.0 52.0 1.0 C13 C:7O9501 1.4 52.0 1.0 F C:7O9501 2.2 52.0 1.0 F1 C:7O9501 2.2 52.0 1.0 C12 C:7O9501 2.3 52.0 1.0 C14 C:7O9501 2.8 52.0 1.0 CZ C:PHE50 3.1 35.6 1.0 CD1 C:ILE16 3.3 48.0 1.0 C11 C:7O9501 3.5 52.0 1.0 CE2 C:PHE50 3.7 35.6 1.0 CB C:ALA205 3.9 40.3 1.0 C15 C:7O9501 4.1 52.0 1.0 CE1 C:PHE50 4.2 35.6 1.0 SD C:MET202 4.5 41.5 1.0 C10 C:7O9501 4.6 52.0 1.0 CG1 C:ILE16 4.7 48.0 1.0 CD1 C:LEU54 4.7 33.2 1.0 CD2 C:LEU387 4.7 42.9 1.0 CE C:MET202 4.8 41.5 1.0 C9 C:7O9501 4.9 52.0 1.0

Fluorine binding site 8 out of 9 in the Inward-Facing State of the Glutamate Transporter Homologue Gltph in Complex with Tfb-Tboa


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 8 of Inward-Facing State of the Glutamate Transporter Homologue Gltph in Complex with Tfb-Tboa within 5.0Å range: probe atom residue distance (Å) B Occ C:F501 b:52.0 occ:1.00 F C:7O9501 0.0 52.0 1.0 C13 C:7O9501 1.4 52.0 1.0 F2 C:7O9501 2.2 52.0 1.0 F1 C:7O9501 2.2 52.0 1.0 C12 C:7O9501 2.4 52.0 1.0 C11 C:7O9501 2.7 52.0 1.0 CD1 C:ILE16 3.3 48.0 1.0 CD2 C:LEU387 3.3 42.9 1.0 C14 C:7O9501 3.6 52.0 1.0 CG C:LEU387 3.9 42.9 1.0 C10 C:7O9501 4.1 52.0 1.0 CG1 C:ILE16 4.3 48.0 1.0 CG2 C:VAL209 4.4 39.6 1.0 C15 C:7O9501 4.7 52.0 1.0 CZ C:PHE50 4.7 35.6 1.0 CE2 C:PHE50 4.8 35.6 1.0 CB C:VAL209 4.8 39.6 1.0 CB C:LEU387 4.9 42.9 1.0 C9 C:7O9501 4.9 52.0 1.0 CD1 C:LEU387 5.0 42.9 1.0

Fluorine binding site 9 out of 9 in the Inward-Facing State of the Glutamate Transporter Homologue Gltph in Complex with Tfb-Tboa


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 9 of Inward-Facing State of the Glutamate Transporter Homologue Gltph in Complex with Tfb-Tboa within 5.0Å range: probe atom residue distance (Å) B Occ C:F501 b:52.0 occ:1.00 F1 C:7O9501 0.0 52.0 1.0 C13 C:7O9501 1.4 52.0 1.0 F2 C:7O9501 2.2 52.0 1.0 F C:7O9501 2.2 52.0 1.0 C12 C:7O9501 2.4 52.0 1.0 C14 C:7O9501 3.0 52.0 1.0 C11 C:7O9501 3.3 52.0 1.0 CD2 C:LEU387 3.3 42.9 1.0 CB C:ALA360 3.9 39.4 1.0 CD1 C:LEU54 4.0 33.2 1.0 CG C:LEU387 4.1 42.9 1.0 CZ C:PHE50 4.1 35.6 1.0 CE2 C:PHE50 4.2 35.6 1.0 OH C:TYR383 4.2 44.6 1.0 C15 C:7O9501 4.3 52.0 1.0 CD1 C:LEU387 4.5 42.9 1.0 C10 C:7O9501 4.5 52.0 1.0 CA C:ALA360 4.9 39.4 1.0 C9 C:7O9501 4.9 52.0 1.0 CZ C:TYR383 5.0 44.6 1.0

X.Wang, O.Boudker. Large Domain Movements Through the Lipid Bilayer Mediate Substrate Release and Inhibition of Glutamate Transporters. Elife V. 9 2020.
ISSN: ESSN 2050-084X
PubMed: 33155546
DOI: 10.7554/ELIFE.58417