Fluorine in PDB 6x19: Non Peptide Agonist Chu-128, Bound to Glucagon-Like Peptide-1 (Glp-1) Receptor

The binding sites of Fluorine atom in the Non Peptide Agonist Chu-128, Bound to Glucagon-Like Peptide-1 (Glp-1) Receptor (pdb code 6x19). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Non Peptide Agonist Chu-128, Bound to Glucagon-Like Peptide-1 (Glp-1) Receptor, PDB code: 6x19:
Jump to Fluorine binding site number: 1; 2;

Fluorine binding site 1 out of 2 in the Non Peptide Agonist Chu-128, Bound to Glucagon-Like Peptide-1 (Glp-1) Receptor


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Non Peptide Agonist Chu-128, Bound to Glucagon-Like Peptide-1 (Glp-1) Receptor within 5.0Å range: probe atom residue distance (Å) B Occ R:F501 b:50.9 occ:1.00 F10 R:UK1501 0.0 50.9 1.0 C06 R:UK1501 1.4 50.9 1.0 C01 R:UK1501 2.4 50.9 1.0 C05 R:UK1501 2.4 50.9 1.0 C08 R:UK1501 3.0 50.9 1.0 C09 R:UK1501 3.0 50.9 1.0 CG R:LEU144 3.3 53.4 1.0 CD2 R:LEU144 3.4 53.4 1.0 CE2 R:TYR148 3.6 43.5 1.0 CB R:LEU141 3.6 59.3 1.0 C04 R:UK1501 3.7 50.9 1.0 C02 R:UK1501 3.7 50.9 1.0 CB R:LEU144 3.8 53.4 1.0 O R:LEU141 3.9 59.3 1.0 CD1 R:LEU141 4.1 59.3 1.0 N R:TYR145 4.2 50.0 1.0 C R:LEU144 4.2 53.4 1.0 C03 R:UK1501 4.3 50.9 1.0 CD2 R:TYR148 4.3 43.5 1.0 CG R:LEU141 4.3 59.3 1.0 OH R:TYR148 4.4 43.5 1.0 CA R:TYR145 4.4 50.0 1.0 CZ R:TYR148 4.5 43.5 1.0 O R:HOH613 4.5 44.2 1.0 CD1 R:LEU144 4.5 53.4 1.0 O R:LEU144 4.5 53.4 1.0 CA R:LEU144 4.7 53.4 1.0 C R:LEU141 4.8 59.3 1.0 CA R:LEU141 4.8 59.3 1.0 CB R:TYR145 4.8 50.0 1.0 CD2 R:LEU141 4.9 59.3 1.0

Fluorine binding site 2 out of 2 in the Non Peptide Agonist Chu-128, Bound to Glucagon-Like Peptide-1 (Glp-1) Receptor


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Non Peptide Agonist Chu-128, Bound to Glucagon-Like Peptide-1 (Glp-1) Receptor within 5.0Å range: probe atom residue distance (Å) B Occ R:F501 b:50.9 occ:1.00 F55 R:UK1501 0.0 50.9 1.0 C47 R:UK1501 1.4 50.9 1.0 C46 R:UK1501 2.4 50.9 1.0 C48 R:UK1501 2.4 50.9 1.0 N43 R:UK1501 3.1 50.9 1.0 C52 R:UK1501 3.2 50.9 1.0 O45 R:UK1501 3.5 50.9 1.0 CB R:LEU201 3.5 51.7 1.0 CE2 R:TYR205 3.5 61.2 1.0 C44 R:UK1501 3.6 50.9 1.0 C49 R:UK1501 3.7 50.9 1.0 C51 R:UK1501 3.7 50.9 1.0 CD1 R:LEU201 3.9 51.7 1.0 OE1 R:GLU138 4.0 62.1 1.0 CZ R:TYR205 4.0 61.2 1.0 OH R:TYR205 4.1 61.2 1.0 CB R:GLU138 4.1 62.1 1.0 CD R:GLU138 4.1 62.1 1.0 C42 R:UK1501 4.2 50.9 1.0 C50 R:UK1501 4.2 50.9 1.0 CD2 R:TYR205 4.2 61.2 1.0 CG R:LEU201 4.2 51.7 1.0 CG R:GLU138 4.4 62.1 1.0 N53 R:UK1501 4.5 50.9 1.0 C R:LEU201 4.6 51.7 1.0 OE2 R:GLU138 4.6 62.1 1.0 CA R:LEU201 4.7 51.7 1.0 O R:LEU201 4.7 51.7 1.0 N54 R:UK1501 4.7 50.9 1.0 N15 R:UK1501 4.7 50.9 1.0 CD2 R:LEU201 4.9 51.7 1.0 N R:LYS202 4.9 54.0 1.0

X.Zhang, M.J.Belousoff, P.Zhao, A.J.Kooistra, T.T.Truong, S.Y.Ang, C.R.Underwood, T.Egebjerg, P.Senel, G.D.Stewart, Y.L.Liang, A.Glukhova, H.Venugopal, A.Christopoulos, S.G.B.Furness, L.J.Miller, S.Reedtz-Runge, C.J.Langmead, D.E.Gloriam, R.Danev, P.M.Sexton, D.Wootten. Differential Glp-1R Binding and Activation By Peptide and Non-Peptide Agonists. Mol.Cell V. 80 485 2020.
ISSN: ISSN 1097-2765
PubMed: 33027691
DOI: 10.1016/J.MOLCEL.2020.09.020