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Atomistry » Fluorine » PDB 6x3c-6xk0 » 6xic | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 6x3c-6xk0 » 6xic » |
Fluorine in PDB 6xic: PCSK9(Deltacrd) in Complex with Cyclic Peptide 40Protein crystallography data
The structure of PCSK9(Deltacrd) in Complex with Cyclic Peptide 40, PDB code: 6xic
was solved by
P.Orth,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the PCSK9(Deltacrd) in Complex with Cyclic Peptide 40
(pdb code 6xic). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the PCSK9(Deltacrd) in Complex with Cyclic Peptide 40, PDB code: 6xic: Jump to Fluorine binding site number: 1; 2; Fluorine binding site 1 out of 2 in 6xicGo back to![]() ![]()
Fluorine binding site 1 out
of 2 in the PCSK9(Deltacrd) in Complex with Cyclic Peptide 40
![]() Mono view ![]() Stereo pair view
Fluorine binding site 2 out of 2 in 6xicGo back to![]() ![]()
Fluorine binding site 2 out
of 2 in the PCSK9(Deltacrd) in Complex with Cyclic Peptide 40
![]() Mono view ![]() Stereo pair view
Reference:
C.Alleyne,
R.P.Amin,
B.Bhatt,
E.Bianchi,
J.C.Blain,
N.Boyer,
D.Branca,
M.W.Embrey,
S.N.Ha,
K.Jette,
D.G.Johns,
A.D.Kerekes,
K.A.Koeplinger,
D.Laplaca,
N.Li,
B.Murphy,
P.Orth,
A.Ricardo,
S.Salowe,
K.Seyb,
A.Shahripour,
J.R.Stringer,
Y.Sun,
R.Tracy,
C.Wu,
Y.Xiong,
H.Youm,
H.J.Zokian,
T.J.Tucker.
Series of Novel and Highly Potent Cyclic Peptide PCSK9 Inhibitors Derived From An Mrna Display Screen and Optimized Via Structure-Based Design. J.Med.Chem. V. 63 13796 2020.
Page generated: Fri Aug 2 04:06:38 2024
ISSN: ISSN 0022-2623 PubMed: 33170686 DOI: 10.1021/ACS.JMEDCHEM.0C01084 |
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