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Fluorine in PDB 6xk9: Cereblon in Complex with DDB1, Cc-90009, and GSPT1Protein crystallography data
The structure of Cereblon in Complex with DDB1, Cc-90009, and GSPT1, PDB code: 6xk9
was solved by
T.L.Clayton,
E.T.Tran,
J.Zhu,
B.E.Pagarigan,
M.E.Matyskiela,
P.P.Chamberlain,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 6xk9:
The structure of Cereblon in Complex with DDB1, Cc-90009, and GSPT1 also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Cereblon in Complex with DDB1, Cc-90009, and GSPT1
(pdb code 6xk9). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 4 binding sites of Fluorine where determined in the Cereblon in Complex with DDB1, Cc-90009, and GSPT1, PDB code: 6xk9: Jump to Fluorine binding site number: 1; 2; 3; 4; Fluorine binding site 1 out of 4 in 6xk9Go back to Fluorine Binding Sites List in 6xk9
Fluorine binding site 1 out
of 4 in the Cereblon in Complex with DDB1, Cc-90009, and GSPT1
Mono view Stereo pair view
Fluorine binding site 2 out of 4 in 6xk9Go back to Fluorine Binding Sites List in 6xk9
Fluorine binding site 2 out
of 4 in the Cereblon in Complex with DDB1, Cc-90009, and GSPT1
Mono view Stereo pair view
Fluorine binding site 3 out of 4 in 6xk9Go back to Fluorine Binding Sites List in 6xk9
Fluorine binding site 3 out
of 4 in the Cereblon in Complex with DDB1, Cc-90009, and GSPT1
Mono view Stereo pair view
Fluorine binding site 4 out of 4 in 6xk9Go back to Fluorine Binding Sites List in 6xk9
Fluorine binding site 4 out
of 4 in the Cereblon in Complex with DDB1, Cc-90009, and GSPT1
Mono view Stereo pair view
Reference:
C.Surka,
L.Jin,
N.Mbong,
C.C.Lu,
I.S.Jang,
E.Rychak,
D.Mendy,
T.Clayton,
E.A.Tindall,
C.Hsu,
C.Fontanillo,
E.Tran,
A.Contreras,
S.W.Ng,
M.E.Matyskiela,
K.Wang,
P.P.Chamberlain,
B.Cathers,
J.Carmichael,
J.D.Hansen,
J.C.Y.Wang,
M.D.Minden,
J.Fan,
D.W.Pierce,
M.Pourdehnad,
M.Rolfe,
A.Lopez-Girona,
J.E.Dick,
G.Lu.
Cc-90009, A Novel Cereblon E3 Ligase Modulator Targets Acute Myeloid Leukemia Blasts and Leukemia Stem Cells. Blood 2020.
Page generated: Sun Dec 13 13:36:43 2020
ISSN: ESSN 1528-0020 PubMed: 33197925 DOI: 10.1182/BLOOD.2020008676 |
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