Fluorine in PDB 6xox: Cryo-Em of Human Glp-1R Bound to Non-Peptide Agonist LY3502970

Fluorine Binding Sites:

The binding sites of Fluorine atom in the Cryo-Em of Human Glp-1R Bound to Non-Peptide Agonist LY3502970 (pdb code 6xox). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Cryo-Em of Human Glp-1R Bound to Non-Peptide Agonist LY3502970, PDB code: 6xox:
Jump to Fluorine binding site number: 1; 2;

Fluorine binding site 1 out of 2 in 6xox

Go back to Fluorine Binding Sites List in 6xox
Fluorine binding site 1 out of 2 in the Cryo-Em of Human Glp-1R Bound to Non-Peptide Agonist LY3502970


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Cryo-Em of Human Glp-1R Bound to Non-Peptide Agonist LY3502970 within 5.0Å range:
probe atom residue distance (Å) B Occ
R:F501

b:0.9
occ:1.00
F01 R:V6G501 0.0 0.9 1.0
C27 R:V6G501 1.3 0.9 1.0
C28 R:V6G501 2.4 0.9 1.0
C26 R:V6G501 2.4 0.9 1.0
C33 R:V6G501 2.9 0.9 1.0
C32 R:V6G501 2.9 0.9 1.0
CD2 R:LEU144 3.2 0.0 1.0
CG R:LEU144 3.5 0.0 1.0
CD2 R:LEU388 3.6 0.1 1.0
C24 R:V6G501 3.6 0.9 1.0
C25 R:V6G501 3.6 0.9 1.0
CE1 R:TYR148 3.8 96.8 1.0
CD1 R:LEU141 4.0 0.3 1.0
C23 R:V6G501 4.0 0.9 1.0
CD1 R:TYR148 4.3 96.8 1.0
CB R:LEU144 4.4 0.0 1.0
CB R:LEU141 4.4 0.3 1.0
CD1 R:LEU144 4.6 0.0 1.0
CZ R:TYR148 4.7 96.8 1.0
CG R:LEU141 4.8 0.3 1.0
CG R:LEU388 4.8 0.1 1.0
O R:LEU141 4.9 0.3 1.0
C R:LEU144 4.9 0.0 1.0
N R:TYR145 4.9 99.9 1.0
OH R:TYR148 4.9 96.8 1.0
CD1 R:LEU388 4.9 0.1 1.0

Fluorine binding site 2 out of 2 in 6xox

Go back to Fluorine Binding Sites List in 6xox
Fluorine binding site 2 out of 2 in the Cryo-Em of Human Glp-1R Bound to Non-Peptide Agonist LY3502970


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Cryo-Em of Human Glp-1R Bound to Non-Peptide Agonist LY3502970 within 5.0Å range:
probe atom residue distance (Å) B Occ
R:F501

b:0.9
occ:1.00
F02 R:V6G501 0.0 0.9 1.0
C35 R:V6G501 1.3 0.9 1.0
C34 R:V6G501 2.3 0.9 1.0
C39 R:V6G501 2.3 0.9 1.0
N08 R:V6G501 2.7 0.9 1.0
C40 R:V6G501 3.0 0.9 1.0
C30 R:V6G501 3.1 0.9 1.0
CD1 R:TYR145 3.3 99.9 1.0
C29 R:V6G501 3.5 0.9 1.0
C38 R:V6G501 3.6 0.9 1.0
C33 R:V6G501 3.6 0.9 1.0
C36 R:V6G501 3.6 0.9 1.0
CE1 R:TYR145 3.7 99.9 1.0
O04 R:V6G501 4.0 0.9 1.0
C31 R:V6G501 4.1 0.9 1.0
CG R:TYR145 4.1 99.9 1.0
C25 R:V6G501 4.1 0.9 1.0
C37 R:V6G501 4.1 0.9 1.0
OH R:TYR148 4.2 96.8 1.0
C26 R:V6G501 4.2 0.9 1.0
N10 R:V6G501 4.3 0.9 1.0
N07 R:V6G501 4.3 0.9 1.0
CB R:ASP198 4.5 99.7 1.0
N09 R:V6G501 4.5 0.9 1.0
CB R:TYR145 4.5 99.9 1.0
CZ R:TYR145 4.7 99.9 1.0
CD2 R:TYR145 5.0 99.9 1.0

Reference:

T.Kawai, B.Sun, H.Yoshino, D.Feng, Y.Suzuki, M.Fukazawa, S.Nagao, D.B.Wainscott, A.D.Showalter, B.A.Droz, T.S.Kobilka, M.P.Coghlan, F.S.Willard, Y.Kawabe, B.K.Kobilka, K.W.Sloop. Structural Basis For Glp-1 Receptor Activation By LY3502970, An Orally Active Nonpeptide Agonist. Proc.Natl.Acad.Sci.Usa V. 117 29959 2020.
ISSN: ESSN 1091-6490
PubMed: 33177239
DOI: 10.1073/PNAS.2014879117
Page generated: Sun Dec 13 13:37:29 2020

Last articles

Zn in 8WB0
Zn in 8WAX
Zn in 8WAU
Zn in 8WAZ
Zn in 8WAY
Zn in 8WAV
Zn in 8WAW
Zn in 8WAT
Zn in 8W7M
Zn in 8WD3
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy