Fluorine in PDB 6xox: Cryo-Em of Human Glp-1R Bound to Non-Peptide Agonist LY3502970

The binding sites of Fluorine atom in the Cryo-Em of Human Glp-1R Bound to Non-Peptide Agonist LY3502970 (pdb code 6xox). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Cryo-Em of Human Glp-1R Bound to Non-Peptide Agonist LY3502970, PDB code: 6xox:
Jump to Fluorine binding site number: 1; 2;

Fluorine binding site 1 out of 2 in the Cryo-Em of Human Glp-1R Bound to Non-Peptide Agonist LY3502970


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Cryo-Em of Human Glp-1R Bound to Non-Peptide Agonist LY3502970 within 5.0Å range: probe atom residue distance (Å) B Occ R:F501 b:0.9 occ:1.00 F01 R:V6G501 0.0 0.9 1.0 C27 R:V6G501 1.3 0.9 1.0 C28 R:V6G501 2.4 0.9 1.0 C26 R:V6G501 2.4 0.9 1.0 C33 R:V6G501 2.9 0.9 1.0 C32 R:V6G501 2.9 0.9 1.0 CD2 R:LEU144 3.2 0.0 1.0 CG R:LEU144 3.5 0.0 1.0 CD2 R:LEU388 3.6 0.1 1.0 C24 R:V6G501 3.6 0.9 1.0 C25 R:V6G501 3.6 0.9 1.0 CE1 R:TYR148 3.8 96.8 1.0 CD1 R:LEU141 4.0 0.3 1.0 C23 R:V6G501 4.0 0.9 1.0 CD1 R:TYR148 4.3 96.8 1.0 CB R:LEU144 4.4 0.0 1.0 CB R:LEU141 4.4 0.3 1.0 CD1 R:LEU144 4.6 0.0 1.0 CZ R:TYR148 4.7 96.8 1.0 CG R:LEU141 4.8 0.3 1.0 CG R:LEU388 4.8 0.1 1.0 O R:LEU141 4.9 0.3 1.0 C R:LEU144 4.9 0.0 1.0 N R:TYR145 4.9 99.9 1.0 OH R:TYR148 4.9 96.8 1.0 CD1 R:LEU388 4.9 0.1 1.0

Fluorine binding site 2 out of 2 in the Cryo-Em of Human Glp-1R Bound to Non-Peptide Agonist LY3502970


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Cryo-Em of Human Glp-1R Bound to Non-Peptide Agonist LY3502970 within 5.0Å range: probe atom residue distance (Å) B Occ R:F501 b:0.9 occ:1.00 F02 R:V6G501 0.0 0.9 1.0 C35 R:V6G501 1.3 0.9 1.0 C34 R:V6G501 2.3 0.9 1.0 C39 R:V6G501 2.3 0.9 1.0 N08 R:V6G501 2.7 0.9 1.0 C40 R:V6G501 3.0 0.9 1.0 C30 R:V6G501 3.1 0.9 1.0 CD1 R:TYR145 3.3 99.9 1.0 C29 R:V6G501 3.5 0.9 1.0 C38 R:V6G501 3.6 0.9 1.0 C33 R:V6G501 3.6 0.9 1.0 C36 R:V6G501 3.6 0.9 1.0 CE1 R:TYR145 3.7 99.9 1.0 O04 R:V6G501 4.0 0.9 1.0 C31 R:V6G501 4.1 0.9 1.0 CG R:TYR145 4.1 99.9 1.0 C25 R:V6G501 4.1 0.9 1.0 C37 R:V6G501 4.1 0.9 1.0 OH R:TYR148 4.2 96.8 1.0 C26 R:V6G501 4.2 0.9 1.0 N10 R:V6G501 4.3 0.9 1.0 N07 R:V6G501 4.3 0.9 1.0 CB R:ASP198 4.5 99.7 1.0 N09 R:V6G501 4.5 0.9 1.0 CB R:TYR145 4.5 99.9 1.0 CZ R:TYR145 4.7 99.9 1.0 CD2 R:TYR145 5.0 99.9 1.0

T.Kawai, B.Sun, H.Yoshino, D.Feng, Y.Suzuki, M.Fukazawa, S.Nagao, D.B.Wainscott, A.D.Showalter, B.A.Droz, T.S.Kobilka, M.P.Coghlan, F.S.Willard, Y.Kawabe, B.K.Kobilka, K.W.Sloop. Structural Basis For Glp-1 Receptor Activation By LY3502970, An Orally Active Nonpeptide Agonist. Proc.Natl.Acad.Sci.Usa V. 117 29959 2020.
ISSN: ESSN 1091-6490
PubMed: 33177239
DOI: 10.1073/PNAS.2014879117