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Fluorine in PDB 6xuq: Human Ecto-5'-Nucleotidase (CD73) in Complex with A1618 (Compound 1B in Publication) in the Closed State in Crystal Form IVEnzymatic activity of Human Ecto-5'-Nucleotidase (CD73) in Complex with A1618 (Compound 1B in Publication) in the Closed State in Crystal Form IV
All present enzymatic activity of Human Ecto-5'-Nucleotidase (CD73) in Complex with A1618 (Compound 1B in Publication) in the Closed State in Crystal Form IV:
3.1.3.5; Protein crystallography data
The structure of Human Ecto-5'-Nucleotidase (CD73) in Complex with A1618 (Compound 1B in Publication) in the Closed State in Crystal Form IV, PDB code: 6xuq
was solved by
N.Strater,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 6xuq:
The structure of Human Ecto-5'-Nucleotidase (CD73) in Complex with A1618 (Compound 1B in Publication) in the Closed State in Crystal Form IV also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Human Ecto-5'-Nucleotidase (CD73) in Complex with A1618 (Compound 1B in Publication) in the Closed State in Crystal Form IV
(pdb code 6xuq). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Human Ecto-5'-Nucleotidase (CD73) in Complex with A1618 (Compound 1B in Publication) in the Closed State in Crystal Form IV, PDB code: 6xuq: Fluorine binding site 1 out of 1 in 6xuqGo back to Fluorine Binding Sites List in 6xuq
Fluorine binding site 1 out
of 1 in the Human Ecto-5'-Nucleotidase (CD73) in Complex with A1618 (Compound 1B in Publication) in the Closed State in Crystal Form IV
Mono view Stereo pair view
Reference:
J.W.Beatty,
E.A.Lindsey,
R.Thomas-Tran,
L.Debien,
D.Mandal,
J.L.Jeffrey,
A.T.Tran,
J.Fournier,
S.D.Jacob,
X.Yan,
S.L.Drew,
E.Ginn,
A.Chen,
A.T.Pham,
S.Zhao,
L.Jin,
S.W.Young,
N.P.Walker,
M.R.Leleti,
S.Moschutz,
N.Strater,
J.P.Powers,
K.V.Lawson.
Discovery of Potent and Selective Non-Nucleotide Small Molecule Inhibitors of CD73. J.Med.Chem. 2020.
Page generated: Sun Dec 13 13:37:57 2020
ISSN: ISSN 0022-2623 PubMed: 32212732 DOI: 10.1021/ACS.JMEDCHEM.9B01713 |
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