Fluorine in PDB 6ysn: Human TRPC5 in Complex with PICO145 (Hc-608)

The structure of Human TRPC5 in Complex with PICO145 (Hc-608) also contains other interesting chemical elements:

Chlorine

(Cl)

4 atoms

Pages:

>>> Page 1 <<< Page 2, Binding sites: 11 - 12;

Binding sites:

The binding sites of Fluorine atom in the Human TRPC5 in Complex with PICO145 (Hc-608) (pdb code 6ysn). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 12 binding sites of Fluorine where determined in the Human TRPC5 in Complex with PICO145 (Hc-608), PDB code: 6ysn:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Fluorine binding site 1 out of 12 in the Human TRPC5 in Complex with PICO145 (Hc-608)


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Human TRPC5 in Complex with PICO145 (Hc-608) within 5.0Å range: probe atom residue distance (Å) B Occ A:F901 b:22.5 occ:1.00 F15 A:PJQ901 0.0 22.5 1.0 C14 A:PJQ901 1.4 22.5 1.0 F17 A:PJQ901 2.2 22.5 1.0 O13 A:PJQ901 2.3 22.5 1.0 F16 A:PJQ901 2.3 22.5 1.0 C12 A:PJQ901 2.8 22.5 1.0 C18 A:PJQ901 3.2 22.5 1.0 CE2 A:TYR524 3.3 29.4 1.0 OH A:TYR524 3.5 29.4 1.0 CZ A:TYR524 3.6 29.4 1.0 CD1 A:PHE576 3.6 17.2 1.0 CE1 A:PHE576 3.6 17.2 1.0 C11 A:PJQ901 3.7 22.5 1.0 CD2 A:TYR524 4.1 29.4 1.0 C08 A:PJQ901 4.3 22.5 1.0 CG2 A:VAL579 4.5 24.7 1.0 CE1 A:TYR524 4.5 29.4 1.0 C10 A:PJQ901 4.7 22.5 1.0 CG A:PHE576 4.8 17.2 1.0 CZ A:PHE576 4.8 17.2 1.0 CG2 D:VAL610 4.9 11.7 1.0 C09 A:PJQ901 5.0 22.5 1.0 CG A:TYR524 5.0 29.4 1.0

Fluorine binding site 2 out of 12 in the Human TRPC5 in Complex with PICO145 (Hc-608)


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Human TRPC5 in Complex with PICO145 (Hc-608) within 5.0Å range: probe atom residue distance (Å) B Occ A:F901 b:22.5 occ:1.00 F16 A:PJQ901 0.0 22.5 1.0 C14 A:PJQ901 1.4 22.5 1.0 F17 A:PJQ901 2.2 22.5 1.0 F15 A:PJQ901 2.3 22.5 1.0 O13 A:PJQ901 2.3 22.5 1.0 C12 A:PJQ901 2.9 22.5 1.0 C11 A:PJQ901 3.0 22.5 1.0 CD2 A:TYR524 3.3 29.4 1.0 CE2 A:TYR524 3.3 29.4 1.0 CG A:TYR524 3.8 29.4 1.0 CZ A:TYR524 3.8 29.4 1.0 CD2 A:LEU521 3.9 34.2 1.0 C18 A:PJQ901 4.1 22.5 1.0 C10 A:PJQ901 4.2 22.5 1.0 CD1 A:TYR524 4.2 29.4 1.0 CE1 A:TYR524 4.3 29.4 1.0 OH A:TYR524 4.5 29.4 1.0 CB A:TYR524 4.6 29.4 1.0

Fluorine binding site 3 out of 12 in the Human TRPC5 in Complex with PICO145 (Hc-608)


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Human TRPC5 in Complex with PICO145 (Hc-608) within 5.0Å range: probe atom residue distance (Å) B Occ A:F901 b:22.5 occ:1.00 F17 A:PJQ901 0.0 22.5 1.0 C14 A:PJQ901 1.3 22.5 1.0 F15 A:PJQ901 2.2 22.5 1.0 F16 A:PJQ901 2.2 22.5 1.0 O13 A:PJQ901 2.2 22.5 1.0 C12 A:PJQ901 3.5 22.5 1.0 CG2 D:VAL610 4.0 11.7 1.0 CG2 D:VAL614 4.0 19.3 1.0 CG1 D:VAL610 4.1 11.7 1.0 C11 A:PJQ901 4.3 22.5 1.0 CG1 D:VAL614 4.3 19.3 1.0 C18 A:PJQ901 4.4 22.5 1.0 CE1 A:PHE576 4.5 17.2 1.0 CB D:VAL614 4.5 19.3 1.0 CB D:VAL610 4.6 11.7 1.0 CZ A:PHE580 4.7 19.7 1.0 CE2 A:TYR524 4.9 29.4 1.0

Fluorine binding site 4 out of 12 in the Human TRPC5 in Complex with PICO145 (Hc-608)


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of Human TRPC5 in Complex with PICO145 (Hc-608) within 5.0Å range: probe atom residue distance (Å) B Occ B:F901 b:23.9 occ:1.00 F15 B:PJQ901 0.0 23.9 1.0 C14 B:PJQ901 1.4 23.9 1.0 F17 B:PJQ901 2.2 23.9 1.0 O13 B:PJQ901 2.3 23.9 1.0 F16 B:PJQ901 2.3 23.9 1.0 C12 B:PJQ901 2.8 23.9 1.0 C18 B:PJQ901 3.2 23.9 1.0 CE2 B:TYR524 3.3 27.4 1.0 OH B:TYR524 3.5 27.4 1.0 CD1 B:PHE576 3.6 18.1 1.0 CE1 B:PHE576 3.6 18.1 1.0 CZ B:TYR524 3.6 27.4 1.0 C11 B:PJQ901 3.7 23.9 1.0 CD2 B:TYR524 4.1 27.4 1.0 C08 B:PJQ901 4.4 23.9 1.0 CG2 B:VAL579 4.5 26.6 1.0 CE1 B:TYR524 4.6 27.4 1.0 C10 B:PJQ901 4.7 23.9 1.0 CG B:PHE576 4.8 18.1 1.0 CZ B:PHE576 4.8 18.1 1.0 CG2 A:VAL610 4.9 16.1 1.0 C09 B:PJQ901 5.0 23.9 1.0

Fluorine binding site 5 out of 12 in the Human TRPC5 in Complex with PICO145 (Hc-608)


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 5 of Human TRPC5 in Complex with PICO145 (Hc-608) within 5.0Å range: probe atom residue distance (Å) B Occ B:F901 b:23.9 occ:1.00 F16 B:PJQ901 0.0 23.9 1.0 C14 B:PJQ901 1.4 23.9 1.0 F17 B:PJQ901 2.2 23.9 1.0 F15 B:PJQ901 2.3 23.9 1.0 O13 B:PJQ901 2.4 23.9 1.0 C12 B:PJQ901 2.9 23.9 1.0 C11 B:PJQ901 3.0 23.9 1.0 CD2 B:TYR524 3.3 27.4 1.0 CE2 B:TYR524 3.3 27.4 1.0 CG B:TYR524 3.8 27.4 1.0 CZ B:TYR524 3.8 27.4 1.0 CD2 B:LEU521 4.0 33.0 1.0 C18 B:PJQ901 4.1 23.9 1.0 C10 B:PJQ901 4.2 23.9 1.0 CD1 B:TYR524 4.2 27.4 1.0 CE1 B:TYR524 4.2 27.4 1.0 OH B:TYR524 4.5 27.4 1.0 CB B:TYR524 4.6 27.4 1.0

Fluorine binding site 6 out of 12 in the Human TRPC5 in Complex with PICO145 (Hc-608)


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 6 of Human TRPC5 in Complex with PICO145 (Hc-608) within 5.0Å range: probe atom residue distance (Å) B Occ B:F901 b:23.9 occ:1.00 F17 B:PJQ901 0.0 23.9 1.0 C14 B:PJQ901 1.3 23.9 1.0 F15 B:PJQ901 2.2 23.9 1.0 F16 B:PJQ901 2.2 23.9 1.0 O13 B:PJQ901 2.2 23.9 1.0 C12 B:PJQ901 3.5 23.9 1.0 CG2 A:VAL614 4.0 21.5 1.0 CG2 A:VAL610 4.0 16.1 1.0 CG1 A:VAL610 4.1 16.1 1.0 CG1 A:VAL614 4.3 21.5 1.0 C11 B:PJQ901 4.3 23.9 1.0 C18 B:PJQ901 4.4 23.9 1.0 CB A:VAL614 4.5 21.5 1.0 CE1 B:PHE576 4.5 18.1 1.0 CB A:VAL610 4.6 16.1 1.0 CZ B:PHE580 4.7 21.0 1.0 CE2 B:TYR524 5.0 27.4 1.0

Fluorine binding site 7 out of 12 in the Human TRPC5 in Complex with PICO145 (Hc-608)


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 7 of Human TRPC5 in Complex with PICO145 (Hc-608) within 5.0Å range: probe atom residue distance (Å) B Occ C:F901 b:21.7 occ:1.00 F15 C:PJQ901 0.0 21.7 1.0 C14 C:PJQ901 1.4 21.7 1.0 F17 C:PJQ901 2.2 21.7 1.0 O13 C:PJQ901 2.3 21.7 1.0 F16 C:PJQ901 2.3 21.7 1.0 C12 C:PJQ901 2.8 21.7 1.0 C18 C:PJQ901 3.2 21.7 1.0 CE2 C:TYR524 3.3 26.7 1.0 OH C:TYR524 3.5 26.7 1.0 CZ C:TYR524 3.6 26.7 1.0 CD1 C:PHE576 3.6 17.3 1.0 CE1 C:PHE576 3.6 17.3 1.0 C11 C:PJQ901 3.7 21.7 1.0 CD2 C:TYR524 4.1 26.7 1.0 C08 C:PJQ901 4.3 21.7 1.0 CG2 C:VAL579 4.5 30.3 1.0 CE1 C:TYR524 4.6 26.7 1.0 C10 C:PJQ901 4.7 21.7 1.0 CG C:PHE576 4.8 17.3 1.0 CZ C:PHE576 4.8 17.3 1.0 CG2 B:VAL610 4.9 15.0 1.0 C09 C:PJQ901 5.0 21.7 1.0 CG C:TYR524 5.0 26.7 1.0

Fluorine binding site 8 out of 12 in the Human TRPC5 in Complex with PICO145 (Hc-608)


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 8 of Human TRPC5 in Complex with PICO145 (Hc-608) within 5.0Å range: probe atom residue distance (Å) B Occ C:F901 b:21.7 occ:1.00 F16 C:PJQ901 0.0 21.7 1.0 C14 C:PJQ901 1.4 21.7 1.0 F17 C:PJQ901 2.2 21.7 1.0 F15 C:PJQ901 2.3 21.7 1.0 O13 C:PJQ901 2.3 21.7 1.0 C12 C:PJQ901 2.9 21.7 1.0 C11 C:PJQ901 3.0 21.7 1.0 CD2 C:TYR524 3.3 26.7 1.0 CE2 C:TYR524 3.3 26.7 1.0 CG C:TYR524 3.8 26.7 1.0 CZ C:TYR524 3.8 26.7 1.0 CD2 C:LEU521 4.0 33.4 1.0 C18 C:PJQ901 4.1 21.7 1.0 C10 C:PJQ901 4.2 21.7 1.0 CD1 C:TYR524 4.2 26.7 1.0 CE1 C:TYR524 4.3 26.7 1.0 OH C:TYR524 4.5 26.7 1.0 CB C:TYR524 4.6 26.7 1.0

Fluorine binding site 9 out of 12 in the Human TRPC5 in Complex with PICO145 (Hc-608)


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 9 of Human TRPC5 in Complex with PICO145 (Hc-608) within 5.0Å range: probe atom residue distance (Å) B Occ C:F901 b:21.7 occ:1.00 F17 C:PJQ901 0.0 21.7 1.0 C14 C:PJQ901 1.3 21.7 1.0 F15 C:PJQ901 2.2 21.7 1.0 F16 C:PJQ901 2.2 21.7 1.0 O13 C:PJQ901 2.2 21.7 1.0 C12 C:PJQ901 3.5 21.7 1.0 CG2 B:VAL610 4.0 15.0 1.0 CG2 B:VAL614 4.0 22.1 1.0 CG1 B:VAL610 4.1 15.0 1.0 C11 C:PJQ901 4.3 21.7 1.0 CG1 B:VAL614 4.3 22.1 1.0 C18 C:PJQ901 4.4 21.7 1.0 CE1 C:PHE576 4.5 17.3 1.0 CB B:VAL614 4.5 22.1 1.0 CB B:VAL610 4.6 15.0 1.0 CZ C:PHE580 4.7 21.0 1.0 CE2 C:TYR524 5.0 26.7 1.0

Fluorine binding site 10 out of 12 in the Human TRPC5 in Complex with PICO145 (Hc-608)


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 10 of Human TRPC5 in Complex with PICO145 (Hc-608) within 5.0Å range: probe atom residue distance (Å) B Occ D:F801 b:21.7 occ:1.00 F15 D:PJQ801 0.0 21.7 1.0 C14 D:PJQ801 1.4 21.7 1.0 F17 D:PJQ801 2.2 21.7 1.0 O13 D:PJQ801 2.3 21.7 1.0 F16 D:PJQ801 2.3 21.7 1.0 C12 D:PJQ801 2.8 21.7 1.0 C18 D:PJQ801 3.2 21.7 1.0 CE2 D:TYR524 3.3 25.9 1.0 OH D:TYR524 3.5 25.9 1.0 CD1 D:PHE576 3.6 17.1 1.0 CE1 D:PHE576 3.6 17.1 1.0 CZ D:TYR524 3.6 25.9 1.0 C11 D:PJQ801 3.7 21.7 1.0 CD2 D:TYR524 4.1 25.9 1.0 C08 D:PJQ801 4.4 21.7 1.0 CG2 D:VAL579 4.5 21.1 1.0 CE1 D:TYR524 4.6 25.9 1.0 C10 D:PJQ801 4.7 21.7 1.0 CG D:PHE576 4.8 17.1 1.0 CZ D:PHE576 4.8 17.1 1.0 CG2 C:VAL610 4.9 12.0 1.0 C09 D:PJQ801 5.0 21.7 1.0 CG D:TYR524 5.0 25.9 1.0

D.J.Wright, K.J.Simmons, R.M.Johnson, D.J.Beech, S.P.Muench, R.S.Bon. Human TRPC5 Structures Reveal Interaction of A Xanthine-Based TRPC1/4/5 Inhibitor with A Conserved Lipid Binding Site. Commun Biol V. 3 704 2020.
ISSN: ESSN 2399-3642
PubMed: 33230284
DOI: 10.1038/S42003-020-01437-8