Fluorine in PDB 6yu4: Crystal Structure of Mhst in Complex with L-4F-Phenylalanine

The structure of Crystal Structure of Mhst in Complex with L-4F-Phenylalanine, PDB code: 6yu4 was solved by D.Focht, C.Neumann, J.Lyons, A.Eguskiza Bilbao, R.Blunck, L.Malinauskaite, I.O.Schwarz, J.A.Javitch, M.Quick, P.Nissen, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	39.31 / 2.26
Space group	P 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	44.150, 49.850, 109.730, 90.00, 96.08, 90.00
R / Rfree (%)	22.3 / 26.1

The structure of Crystal Structure of Mhst in Complex with L-4F-Phenylalanine also contains other interesting chemical elements:

Sodium

(Na)

2 atoms

The binding sites of Fluorine atom in the Crystal Structure of Mhst in Complex with L-4F-Phenylalanine (pdb code 6yu4). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Crystal Structure of Mhst in Complex with L-4F-Phenylalanine, PDB code: 6yu4:

Fluorine binding site 1 out of 1 in the Crystal Structure of Mhst in Complex with L-4F-Phenylalanine


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Crystal Structure of Mhst in Complex with L-4F-Phenylalanine within 5.0Å range: probe atom residue distance (Å) B Occ A:F703 b:37.2 occ:1.00 F A:PFF703 0.0 37.2 1.0 CZ A:PFF703 1.4 34.2 1.0 CE2 A:PFF703 2.4 33.0 1.0 CE1 A:PFF703 2.4 30.9 1.0 SD A:MET236 2.9 43.3 1.0 CB A:ALA238 3.0 27.6 1.0 CE A:MET236 3.2 41.7 1.0 CG A:MET236 3.4 41.8 1.0 CD2 A:PFF703 3.6 34.2 1.0 CD1 A:PFF703 3.6 27.3 1.0 CD2 A:LEU328 3.7 29.2 1.0 CB A:SER233 4.1 28.2 1.0 CG A:PFF703 4.1 26.6 1.0 O A:SER233 4.1 36.3 1.0 CA A:SER233 4.2 30.1 1.0 C A:SER233 4.3 33.9 1.0 CG A:LEU328 4.3 24.5 1.0 CA A:ALA238 4.4 36.4 1.0 OG A:SER327 4.6 35.4 1.0 CA A:LEU328 4.7 29.8 1.0 N A:ALA238 4.7 34.6 1.0 O A:HOH805 4.8 39.1 1.0 OG A:SER233 4.8 30.6 1.0 CB A:MET236 4.8 31.6 1.0 O A:SER327 4.8 30.0 1.0 CG2 A:VAL331 4.9 37.8 1.0 N A:LEU328 4.9 25.4 1.0

D.Focht, C.Neumann, J.Lyons, A.Eguskiza Bilbao, R.Blunck, L.Malinauskaite, I.O.Schwarz, J.A.Javitch, M.Quick, P.Nissen. Role of A Non-Helical Region of Transmembrane Helix 6 in the Substrate Recognition Mechanism of the Hydrophobic Amino Acid Transporter Mhst. To Be Published.