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Atomistry » Fluorine » PDB 6z4d-6zpl » 6z9b » |
Fluorine in PDB 6z9b: Human Ecto-5'-Nucleotidase (CD73) in Complex with Aopcp Derivative A830 (Compound 16 in Publication) in the Closed Form (Crystal Form III)Enzymatic activity of Human Ecto-5'-Nucleotidase (CD73) in Complex with Aopcp Derivative A830 (Compound 16 in Publication) in the Closed Form (Crystal Form III)
All present enzymatic activity of Human Ecto-5'-Nucleotidase (CD73) in Complex with Aopcp Derivative A830 (Compound 16 in Publication) in the Closed Form (Crystal Form III):
3.1.3.5; Protein crystallography data
The structure of Human Ecto-5'-Nucleotidase (CD73) in Complex with Aopcp Derivative A830 (Compound 16 in Publication) in the Closed Form (Crystal Form III), PDB code: 6z9b
was solved by
N.Strater,
E.Scaletti,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 6z9b:
The structure of Human Ecto-5'-Nucleotidase (CD73) in Complex with Aopcp Derivative A830 (Compound 16 in Publication) in the Closed Form (Crystal Form III) also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Human Ecto-5'-Nucleotidase (CD73) in Complex with Aopcp Derivative A830 (Compound 16 in Publication) in the Closed Form (Crystal Form III)
(pdb code 6z9b). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Human Ecto-5'-Nucleotidase (CD73) in Complex with Aopcp Derivative A830 (Compound 16 in Publication) in the Closed Form (Crystal Form III), PDB code: 6z9b: Fluorine binding site 1 out of 1 in 6z9bGo back to![]() ![]()
Fluorine binding site 1 out
of 1 in the Human Ecto-5'-Nucleotidase (CD73) in Complex with Aopcp Derivative A830 (Compound 16 in Publication) in the Closed Form (Crystal Form III)
![]() Mono view ![]() Stereo pair view
Reference:
K.V.Lawson,
J.Kalisiak,
E.A.Lindsey,
E.T.Newcomb,
M.R.Leleti,
L.Debien,
B.R.Rosen,
D.H.Miles,
E.U.Sharif,
J.L.Jeffrey,
J.B.L.Tan,
A.Chen,
S.Zhao,
G.Xu,
L.Fu,
L.Jin,
T.W.Park,
W.Berry,
S.Moschutz,
E.Scaletti,
N.Strater,
N.P.Walker,
S.W.Young,
M.J.Walters,
U.Schindler,
J.P.Powers.
Discovery of AB680: A Potent and Selective Inhibitor of CD73. J.Med.Chem. V. 63 11448 2020.
Page generated: Fri Aug 2 05:02:18 2024
ISSN: ISSN 0022-2623 PubMed: 32614585 DOI: 10.1021/ACS.JMEDCHEM.0C00525 |
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