Fluorine in PDB 6zbt: Structure of 14-3-3 Gamma in Complex with NEDD4-2 14-3-3 Binding Motif SER342
Enzymatic activity of Structure of 14-3-3 Gamma in Complex with NEDD4-2 14-3-3 Binding Motif SER342
All present enzymatic activity of Structure of 14-3-3 Gamma in Complex with NEDD4-2 14-3-3 Binding Motif SER342:
2.3.2.26;
Protein crystallography data
The structure of Structure of 14-3-3 Gamma in Complex with NEDD4-2 14-3-3 Binding Motif SER342, PDB code: 6zbt
was solved by
R.Joshi,
D.Kalabova,
T.Obsil,
V.Obsilova,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Resolution Low / High (Å)
|
27.51 /
1.80
|
Space group
|
H 3
|
Cell size a, b, c (Å), α, β, γ (°)
|
205.857,
205.857,
74.354,
90,
90,
120
|
R / Rfree (%)
|
21 /
24.1
|
Fluorine Binding Sites:
Pages:
>>> Page 1 <<<
Page 2, Binding sites: 11 -
20;
Page 3, Binding sites: 21 -
24;
Binding sites:
The binding sites of Fluorine atom in the Structure of 14-3-3 Gamma in Complex with NEDD4-2 14-3-3 Binding Motif SER342
(pdb code 6zbt). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 24 binding sites of Fluorine where determined in the
Structure of 14-3-3 Gamma in Complex with NEDD4-2 14-3-3 Binding Motif SER342, PDB code: 6zbt:
Jump to Fluorine binding site number:
1;
2;
3;
4;
5;
6;
7;
8;
9;
10;
Fluorine binding site 1 out
of 24 in 6zbt
Go back to
Fluorine Binding Sites List in 6zbt
Fluorine binding site 1 out
of 24 in the Structure of 14-3-3 Gamma in Complex with NEDD4-2 14-3-3 Binding Motif SER342
Mono view
Stereo pair view
|
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Structure of 14-3-3 Gamma in Complex with NEDD4-2 14-3-3 Binding Motif SER342 within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:F301
b:59.9
occ:1.00
|
F7
|
A:CFH301
|
0.0
|
59.9
|
1.0
|
C1
|
A:CFH301
|
1.4
|
61.5
|
1.0
|
F6
|
A:CFH301
|
2.2
|
64.0
|
1.0
|
F5
|
A:CFH301
|
2.2
|
69.4
|
1.0
|
C2
|
A:CFH301
|
2.4
|
54.4
|
1.0
|
O4
|
A:CFH301
|
2.6
|
49.3
|
1.0
|
F6
|
A:CFH302
|
3.0
|
63.5
|
1.0
|
F8
|
A:CFH301
|
3.1
|
47.6
|
1.0
|
C3
|
A:CFH301
|
3.2
|
51.8
|
1.0
|
CE2
|
A:PHE201
|
3.2
|
47.6
|
1.0
|
CD2
|
A:PHE201
|
3.3
|
45.9
|
1.0
|
F10
|
A:CFH302
|
3.3
|
45.0
|
1.0
|
F7
|
A:CFH302
|
3.4
|
51.8
|
1.0
|
F10
|
A:CFH301
|
3.6
|
54.0
|
1.0
|
C1
|
A:CFH302
|
3.7
|
56.9
|
1.0
|
F9
|
A:CFH302
|
3.9
|
54.9
|
1.0
|
C3
|
A:CFH302
|
4.1
|
48.3
|
1.0
|
F9
|
A:CFH301
|
4.4
|
51.5
|
1.0
|
C2
|
A:CFH302
|
4.4
|
54.5
|
1.0
|
CZ
|
A:PHE201
|
4.5
|
42.9
|
1.0
|
CG
|
A:PHE201
|
4.6
|
37.7
|
1.0
|
CB
|
A:ASP202
|
4.8
|
42.4
|
1.0
|
OD1
|
A:ASP202
|
4.9
|
32.7
|
1.0
|
F5
|
A:CFH302
|
4.9
|
58.8
|
1.0
|
|
Fluorine binding site 2 out
of 24 in 6zbt
Go back to
Fluorine Binding Sites List in 6zbt
Fluorine binding site 2 out
of 24 in the Structure of 14-3-3 Gamma in Complex with NEDD4-2 14-3-3 Binding Motif SER342
Mono view
Stereo pair view
|
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Structure of 14-3-3 Gamma in Complex with NEDD4-2 14-3-3 Binding Motif SER342 within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:F301
b:69.4
occ:1.00
|
F5
|
A:CFH301
|
0.0
|
69.4
|
1.0
|
C1
|
A:CFH301
|
1.4
|
61.5
|
1.0
|
F6
|
A:CFH301
|
2.2
|
64.0
|
1.0
|
F7
|
A:CFH301
|
2.2
|
59.9
|
1.0
|
F8
|
A:CFH301
|
2.3
|
47.6
|
1.0
|
C2
|
A:CFH301
|
2.4
|
54.4
|
1.0
|
C3
|
A:CFH301
|
2.8
|
51.8
|
1.0
|
F7
|
A:CFH302
|
3.5
|
51.8
|
1.0
|
F9
|
A:CFH301
|
3.5
|
51.5
|
1.0
|
O4
|
A:CFH301
|
3.5
|
49.3
|
1.0
|
F10
|
A:CFH301
|
3.9
|
54.0
|
1.0
|
F6
|
A:CFH302
|
4.0
|
63.5
|
1.0
|
CE
|
A:LYS198
|
4.2
|
50.9
|
1.0
|
F10
|
A:CFH302
|
4.3
|
45.0
|
1.0
|
C1
|
A:CFH302
|
4.4
|
56.9
|
1.0
|
NZ
|
A:LYS198
|
4.6
|
62.4
|
1.0
|
OD1
|
A:ASP202
|
5.0
|
32.7
|
1.0
|
|
Fluorine binding site 3 out
of 24 in 6zbt
Go back to
Fluorine Binding Sites List in 6zbt
Fluorine binding site 3 out
of 24 in the Structure of 14-3-3 Gamma in Complex with NEDD4-2 14-3-3 Binding Motif SER342
Mono view
Stereo pair view
|
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Structure of 14-3-3 Gamma in Complex with NEDD4-2 14-3-3 Binding Motif SER342 within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:F301
b:64.0
occ:1.00
|
F6
|
A:CFH301
|
0.0
|
64.0
|
1.0
|
C1
|
A:CFH301
|
1.4
|
61.5
|
1.0
|
F7
|
A:CFH301
|
2.2
|
59.9
|
1.0
|
F5
|
A:CFH301
|
2.2
|
69.4
|
1.0
|
C2
|
A:CFH301
|
2.4
|
54.4
|
1.0
|
O4
|
A:CFH301
|
2.9
|
49.3
|
1.0
|
CB
|
A:ASP202
|
3.2
|
42.4
|
1.0
|
OD1
|
A:ASP202
|
3.7
|
32.7
|
1.0
|
C3
|
A:CFH301
|
3.7
|
51.8
|
1.0
|
CG
|
A:ASP202
|
3.8
|
42.8
|
1.0
|
F8
|
A:CFH301
|
4.0
|
47.6
|
1.0
|
CA
|
A:ASP202
|
4.0
|
38.4
|
1.0
|
CG
|
A:LYS198
|
4.2
|
47.8
|
1.0
|
O
|
A:LYS198
|
4.2
|
37.6
|
1.0
|
CD2
|
A:PHE201
|
4.2
|
45.9
|
1.0
|
CE
|
A:LYS198
|
4.3
|
50.9
|
1.0
|
N
|
A:ASP202
|
4.3
|
36.3
|
1.0
|
NZ
|
A:LYS198
|
4.4
|
62.4
|
1.0
|
F9
|
A:CFH301
|
4.4
|
51.5
|
1.0
|
F10
|
A:CFH301
|
4.6
|
54.0
|
1.0
|
CE2
|
A:PHE201
|
4.7
|
47.6
|
1.0
|
F10
|
A:CFH302
|
4.8
|
45.0
|
1.0
|
OD2
|
A:ASP202
|
4.8
|
42.0
|
1.0
|
CD
|
A:LYS198
|
4.8
|
51.9
|
1.0
|
|
Fluorine binding site 4 out
of 24 in 6zbt
Go back to
Fluorine Binding Sites List in 6zbt
Fluorine binding site 4 out
of 24 in the Structure of 14-3-3 Gamma in Complex with NEDD4-2 14-3-3 Binding Motif SER342
Mono view
Stereo pair view
|
A full contact list of Fluorine with other atoms in the F binding
site number 4 of Structure of 14-3-3 Gamma in Complex with NEDD4-2 14-3-3 Binding Motif SER342 within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:F301
b:54.0
occ:1.00
|
F10
|
A:CFH301
|
0.0
|
54.0
|
1.0
|
C3
|
A:CFH301
|
1.4
|
51.8
|
1.0
|
F9
|
A:CFH301
|
2.2
|
51.5
|
1.0
|
F8
|
A:CFH301
|
2.2
|
47.6
|
1.0
|
C2
|
A:CFH301
|
2.4
|
54.4
|
1.0
|
O4
|
A:CFH301
|
2.4
|
49.3
|
1.0
|
C1
|
A:CFH301
|
3.5
|
61.5
|
1.0
|
F7
|
A:CFH301
|
3.6
|
59.9
|
1.0
|
F5
|
A:CFH301
|
3.9
|
69.4
|
1.0
|
F6
|
A:CFH302
|
4.0
|
63.5
|
1.0
|
F6
|
A:CFH301
|
4.6
|
64.0
|
1.0
|
OD1
|
A:ASP202
|
4.7
|
32.7
|
1.0
|
CG2
|
A:ILE205
|
4.9
|
40.4
|
1.0
|
|
Fluorine binding site 5 out
of 24 in 6zbt
Go back to
Fluorine Binding Sites List in 6zbt
Fluorine binding site 5 out
of 24 in the Structure of 14-3-3 Gamma in Complex with NEDD4-2 14-3-3 Binding Motif SER342
Mono view
Stereo pair view
|
A full contact list of Fluorine with other atoms in the F binding
site number 5 of Structure of 14-3-3 Gamma in Complex with NEDD4-2 14-3-3 Binding Motif SER342 within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:F301
b:47.6
occ:1.00
|
F8
|
A:CFH301
|
0.0
|
47.6
|
1.0
|
C3
|
A:CFH301
|
1.4
|
51.8
|
1.0
|
F10
|
A:CFH301
|
2.2
|
54.0
|
1.0
|
F9
|
A:CFH301
|
2.2
|
51.5
|
1.0
|
F5
|
A:CFH301
|
2.3
|
69.4
|
1.0
|
C2
|
A:CFH301
|
2.4
|
54.4
|
1.0
|
C1
|
A:CFH301
|
2.7
|
61.5
|
1.0
|
F7
|
A:CFH301
|
3.1
|
59.9
|
1.0
|
O4
|
A:CFH301
|
3.4
|
49.3
|
1.0
|
F6
|
A:CFH302
|
3.5
|
63.5
|
1.0
|
F7
|
A:CFH302
|
3.7
|
51.8
|
1.0
|
F6
|
A:CFH301
|
4.0
|
64.0
|
1.0
|
C1
|
A:CFH302
|
4.1
|
56.9
|
1.0
|
F5
|
A:CFH302
|
4.4
|
58.8
|
1.0
|
|
Fluorine binding site 6 out
of 24 in 6zbt
Go back to
Fluorine Binding Sites List in 6zbt
Fluorine binding site 6 out
of 24 in the Structure of 14-3-3 Gamma in Complex with NEDD4-2 14-3-3 Binding Motif SER342
Mono view
Stereo pair view
|
A full contact list of Fluorine with other atoms in the F binding
site number 6 of Structure of 14-3-3 Gamma in Complex with NEDD4-2 14-3-3 Binding Motif SER342 within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:F301
b:51.5
occ:1.00
|
F9
|
A:CFH301
|
0.0
|
51.5
|
1.0
|
C3
|
A:CFH301
|
1.4
|
51.8
|
1.0
|
F10
|
A:CFH301
|
2.2
|
54.0
|
1.0
|
F8
|
A:CFH301
|
2.2
|
47.6
|
1.0
|
C2
|
A:CFH301
|
2.4
|
54.4
|
1.0
|
O4
|
A:CFH301
|
3.3
|
49.3
|
1.0
|
C1
|
A:CFH301
|
3.5
|
61.5
|
1.0
|
F5
|
A:CFH301
|
3.5
|
69.4
|
1.0
|
OD1
|
A:ASP202
|
4.2
|
32.7
|
1.0
|
F7
|
A:CFH301
|
4.4
|
59.9
|
1.0
|
F6
|
A:CFH301
|
4.4
|
64.0
|
1.0
|
|
Fluorine binding site 7 out
of 24 in 6zbt
Go back to
Fluorine Binding Sites List in 6zbt
Fluorine binding site 7 out
of 24 in the Structure of 14-3-3 Gamma in Complex with NEDD4-2 14-3-3 Binding Motif SER342
Mono view
Stereo pair view
|
A full contact list of Fluorine with other atoms in the F binding
site number 7 of Structure of 14-3-3 Gamma in Complex with NEDD4-2 14-3-3 Binding Motif SER342 within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:F302
b:51.8
occ:1.00
|
F7
|
A:CFH302
|
0.0
|
51.8
|
1.0
|
C1
|
A:CFH302
|
1.4
|
56.9
|
1.0
|
F6
|
A:CFH302
|
2.2
|
63.5
|
1.0
|
F5
|
A:CFH302
|
2.2
|
58.8
|
1.0
|
C2
|
A:CFH302
|
2.4
|
54.5
|
1.0
|
F10
|
A:CFH302
|
2.5
|
45.0
|
1.0
|
C3
|
A:CFH302
|
2.9
|
48.3
|
1.0
|
F7
|
A:CFH301
|
3.4
|
59.9
|
1.0
|
F5
|
A:CFH301
|
3.5
|
69.4
|
1.0
|
O4
|
A:CFH302
|
3.6
|
53.9
|
1.0
|
F8
|
A:CFH301
|
3.7
|
47.6
|
1.0
|
F9
|
A:CFH302
|
3.8
|
54.9
|
1.0
|
F8
|
A:CFH302
|
3.9
|
55.7
|
1.0
|
C1
|
A:CFH301
|
4.1
|
61.5
|
1.0
|
C3
|
A:CFH301
|
4.8
|
51.8
|
1.0
|
|
Fluorine binding site 8 out
of 24 in 6zbt
Go back to
Fluorine Binding Sites List in 6zbt
Fluorine binding site 8 out
of 24 in the Structure of 14-3-3 Gamma in Complex with NEDD4-2 14-3-3 Binding Motif SER342
Mono view
Stereo pair view
|
A full contact list of Fluorine with other atoms in the F binding
site number 8 of Structure of 14-3-3 Gamma in Complex with NEDD4-2 14-3-3 Binding Motif SER342 within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:F302
b:58.8
occ:1.00
|
F5
|
A:CFH302
|
0.0
|
58.8
|
1.0
|
C1
|
A:CFH302
|
1.4
|
56.9
|
1.0
|
F6
|
A:CFH302
|
2.2
|
63.5
|
1.0
|
F7
|
A:CFH302
|
2.2
|
51.8
|
1.0
|
C2
|
A:CFH302
|
2.4
|
54.5
|
1.0
|
O4
|
A:CFH302
|
2.8
|
53.9
|
1.0
|
C3
|
A:CFH302
|
3.8
|
48.3
|
1.0
|
F10
|
A:CFH302
|
4.1
|
45.0
|
1.0
|
F8
|
A:CFH301
|
4.4
|
47.6
|
1.0
|
F9
|
A:CFH302
|
4.5
|
54.9
|
1.0
|
F8
|
A:CFH302
|
4.6
|
55.7
|
1.0
|
F7
|
A:CFH301
|
4.9
|
59.9
|
1.0
|
|
Fluorine binding site 9 out
of 24 in 6zbt
Go back to
Fluorine Binding Sites List in 6zbt
Fluorine binding site 9 out
of 24 in the Structure of 14-3-3 Gamma in Complex with NEDD4-2 14-3-3 Binding Motif SER342
Mono view
Stereo pair view
|
A full contact list of Fluorine with other atoms in the F binding
site number 9 of Structure of 14-3-3 Gamma in Complex with NEDD4-2 14-3-3 Binding Motif SER342 within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:F302
b:63.5
occ:1.00
|
F6
|
A:CFH302
|
0.0
|
63.5
|
1.0
|
C1
|
A:CFH302
|
1.4
|
56.9
|
1.0
|
F5
|
A:CFH302
|
2.2
|
58.8
|
1.0
|
F7
|
A:CFH302
|
2.2
|
51.8
|
1.0
|
C2
|
A:CFH302
|
2.4
|
54.5
|
1.0
|
O4
|
A:CFH302
|
2.7
|
53.9
|
1.0
|
F7
|
A:CFH301
|
3.0
|
59.9
|
1.0
|
C3
|
A:CFH302
|
3.1
|
48.3
|
1.0
|
F9
|
A:CFH302
|
3.2
|
54.9
|
1.0
|
F10
|
A:CFH302
|
3.2
|
45.0
|
1.0
|
F8
|
A:CFH301
|
3.5
|
47.6
|
1.0
|
C1
|
A:CFH301
|
4.0
|
61.5
|
1.0
|
CE2
|
A:PHE201
|
4.0
|
47.6
|
1.0
|
F10
|
A:CFH301
|
4.0
|
54.0
|
1.0
|
F5
|
A:CFH301
|
4.0
|
69.4
|
1.0
|
C3
|
A:CFH301
|
4.1
|
51.8
|
1.0
|
F8
|
A:CFH302
|
4.4
|
55.7
|
1.0
|
C2
|
A:CFH301
|
4.4
|
54.4
|
1.0
|
O4
|
A:CFH301
|
4.5
|
49.3
|
1.0
|
CZ
|
A:PHE201
|
4.6
|
42.9
|
1.0
|
CD2
|
A:PHE201
|
4.8
|
45.9
|
1.0
|
|
Fluorine binding site 10 out
of 24 in 6zbt
Go back to
Fluorine Binding Sites List in 6zbt
Fluorine binding site 10 out
of 24 in the Structure of 14-3-3 Gamma in Complex with NEDD4-2 14-3-3 Binding Motif SER342
Mono view
Stereo pair view
|
A full contact list of Fluorine with other atoms in the F binding
site number 10 of Structure of 14-3-3 Gamma in Complex with NEDD4-2 14-3-3 Binding Motif SER342 within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:F302
b:45.0
occ:1.00
|
F10
|
A:CFH302
|
0.0
|
45.0
|
1.0
|
C3
|
A:CFH302
|
1.4
|
48.3
|
1.0
|
F8
|
A:CFH302
|
2.2
|
55.7
|
1.0
|
F9
|
A:CFH302
|
2.2
|
54.9
|
1.0
|
C2
|
A:CFH302
|
2.4
|
54.5
|
1.0
|
F7
|
A:CFH302
|
2.5
|
51.8
|
1.0
|
C1
|
A:CFH302
|
2.8
|
56.9
|
1.0
|
F6
|
A:CFH302
|
3.2
|
63.5
|
1.0
|
F7
|
A:CFH301
|
3.3
|
59.9
|
1.0
|
O4
|
A:CFH302
|
3.5
|
53.9
|
1.0
|
F5
|
A:CFH302
|
4.1
|
58.8
|
1.0
|
CD1
|
A:LEU230
|
4.1
|
39.5
|
1.0
|
CE2
|
A:PHE201
|
4.3
|
47.6
|
1.0
|
F5
|
A:CFH301
|
4.3
|
69.4
|
1.0
|
C1
|
A:CFH301
|
4.3
|
61.5
|
1.0
|
CD2
|
A:PHE201
|
4.3
|
45.9
|
1.0
|
F6
|
A:CFH301
|
4.8
|
64.0
|
1.0
|
|
Reference:
P.Pohl,
R.Joshi,
D.Kalabova,
T.Obsil,
V.Obsilova.
14-3-3-Protein Regulates NEDD4-2 By Modulating Interactions Between Hect and Ww Domains Commun Biol 2021.
ISSN: ESSN 2399-3642
DOI: 10.1038/S42003-021-02419-0
Page generated: Fri Aug 2 05:03:08 2024
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