Fluorine in PDB 6zcr: Syk Kinase Domain in Complex with Azabenzimidazole Inhibitor 7

All present enzymatic activity of Syk Kinase Domain in Complex with Azabenzimidazole Inhibitor 7:
2.7.10.2;

The structure of Syk Kinase Domain in Complex with Azabenzimidazole Inhibitor 7, PDB code: 6zcr was solved by J.A.Read, J.Patel, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	60.26 / 1.73
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	39.46, 82.791, 87.876, 90, 90, 90
R / Rfree (%)	18.8 / 21.8

The structure of Syk Kinase Domain in Complex with Azabenzimidazole Inhibitor 7 also contains other interesting chemical elements:

Chlorine

(Cl)

1 atom

The binding sites of Fluorine atom in the Syk Kinase Domain in Complex with Azabenzimidazole Inhibitor 7 (pdb code 6zcr). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Syk Kinase Domain in Complex with Azabenzimidazole Inhibitor 7, PDB code: 6zcr:

Fluorine binding site 1 out of 1 in the Syk Kinase Domain in Complex with Azabenzimidazole Inhibitor 7


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Syk Kinase Domain in Complex with Azabenzimidazole Inhibitor 7 within 5.0Å range: probe atom residue distance (Å) B Occ A:F701 b:32.6 occ:1.00 F11 A:5JG701 0.0 32.6 1.0 C6 A:5JG701 1.4 30.5 1.0 C7 A:5JG701 2.3 32.3 1.0 C5 A:5JG701 2.4 27.8 1.0 N13 A:5JG701 2.7 25.1 1.0 O A:ALA451 2.8 28.1 1.0 C12 A:5JG701 2.8 25.3 1.0 O A:GLU452 3.1 26.8 1.0 C A:GLU452 3.4 29.5 1.0 N A:GLY454 3.4 27.1 1.0 CA A:GLY454 3.6 26.2 1.0 C8 A:5JG701 3.6 34.1 1.0 C4 A:5JG701 3.6 28.2 1.0 CA A:GLU452 3.7 26.8 1.0 C A:ALA451 3.8 28.2 1.0 C14 A:5JG701 4.0 24.1 1.0 N A:LEU453 4.1 26.6 1.0 C3 A:5JG701 4.1 31.9 1.0 SD A:MET450 4.1 38.2 1.0 N16 A:5JG701 4.1 21.6 1.0 C A:LEU453 4.2 31.5 1.0 N A:GLU452 4.2 27.3 1.0 CD2 A:LEU377 4.5 30.6 1.0 CA A:LEU453 4.6 26.6 1.0 C15 A:5JG701 4.7 23.2 1.0 O9 A:5JG701 4.8 37.7 1.0 N20 A:5JG701 4.8 25.3 1.0 O A:LEU453 4.9 31.3 1.0

J.A.Read, J.A.Read, J.Patel. N/A N/A.