Fluorine in PDB 6zfs: Crystal Structure of Bovine Cytochrome BC1 in Complex with Quinolone Inhibitor Wdh-1U-4
Enzymatic activity of Crystal Structure of Bovine Cytochrome BC1 in Complex with Quinolone Inhibitor Wdh-1U-4
All present enzymatic activity of Crystal Structure of Bovine Cytochrome BC1 in Complex with Quinolone Inhibitor Wdh-1U-4:
7.1.1.8;
7.1.1.8;
Protein crystallography data
The structure of Crystal Structure of Bovine Cytochrome BC1 in Complex with Quinolone Inhibitor Wdh-1U-4, PDB code: 6zfs
was solved by
K.Amporndanai,
P.M.O'neill,
W.D.Hong,
R.K.Amewu,
C.Pidathala,
N.G.Berry,
G.A.Biagini,
S.C.Leung,
S.S.Hasnain,
S.V.Antonyuk,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 90.74 / 3.50 |
| Space group | P 65 2 2 |
| Cell size a, b, c (Å), α, β, γ (°) | 209.56, 209.56, 343.348, 90, 90, 120 |
| R / Rfree (%) | 21.7 / 24.6 |
Other elements in 6zfs:
The structure of Crystal Structure of Bovine Cytochrome BC1 in Complex with Quinolone Inhibitor Wdh-1U-4 also contains other interesting chemical elements:
| Iron | (Fe) | 5 atoms |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of Bovine Cytochrome BC1 in Complex with Quinolone Inhibitor Wdh-1U-4
(pdb code 6zfs). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the Crystal Structure of Bovine Cytochrome BC1 in Complex with Quinolone Inhibitor Wdh-1U-4, PDB code: 6zfs:
Jump to Fluorine binding site number: 1; 2; 3;
In total 3 binding sites of Fluorine where determined in the Crystal Structure of Bovine Cytochrome BC1 in Complex with Quinolone Inhibitor Wdh-1U-4, PDB code: 6zfs:
Jump to Fluorine binding site number: 1; 2; 3;
Fluorine binding site 1 out of 3 in 6zfs
Go back to
Fluorine Binding Sites List in 6zfs
Fluorine binding site 1 out
of 3 in the Crystal Structure of Bovine Cytochrome BC1 in Complex with Quinolone Inhibitor Wdh-1U-4
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Crystal Structure of Bovine Cytochrome BC1 in Complex with Quinolone Inhibitor Wdh-1U-4 within 5.0Å range:
|
Fluorine binding site 2 out of 3 in 6zfs
Go back to
Fluorine Binding Sites List in 6zfs
Fluorine binding site 2 out
of 3 in the Crystal Structure of Bovine Cytochrome BC1 in Complex with Quinolone Inhibitor Wdh-1U-4
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Crystal Structure of Bovine Cytochrome BC1 in Complex with Quinolone Inhibitor Wdh-1U-4 within 5.0Å range:
|
Fluorine binding site 3 out of 3 in 6zfs
Go back to
Fluorine Binding Sites List in 6zfs
Fluorine binding site 3 out
of 3 in the Crystal Structure of Bovine Cytochrome BC1 in Complex with Quinolone Inhibitor Wdh-1U-4
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Crystal Structure of Bovine Cytochrome BC1 in Complex with Quinolone Inhibitor Wdh-1U-4 within 5.0Å range:
|
Reference:
K.Amporndanai,
P.M.O'neill,
W.D.Hong,
R.K.Amewu,
C.Pidathala,
N.Berry,
G.A.Biangini,
S.C.Leung,
S.S.Hasnain,
S.V.Antonyuk.
Targeting the Ubiquinol-Reduction (Qi) Site of the Mitochondrial Cytochrome BC1 Complex For the Development of Next Generation Quinolone Antimalarials To Be Published.
Page generated: Sat Jul 10 13:56:54 2021
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