Atomistry » Fluorine » PDB 6z4d-6zpl » 6zg9
Atomistry »
  Fluorine »
    PDB 6z4d-6zpl »
      6zg9 »

Fluorine in PDB 6zg9: Structure of M1-Star-T4L in Complex with GSK1034702 at 2.5A

Enzymatic activity of Structure of M1-Star-T4L in Complex with GSK1034702 at 2.5A

All present enzymatic activity of Structure of M1-Star-T4L in Complex with GSK1034702 at 2.5A:
3.2.1.17;

Protein crystallography data

The structure of Structure of M1-Star-T4L in Complex with GSK1034702 at 2.5A, PDB code: 6zg9 was solved by P.Rucktooa, R.M.Cooke, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 33.97 / 2.50
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 62.363, 66.571, 153.102, 90, 90, 90
R / Rfree (%) 20.3 / 24.2

Fluorine Binding Sites:

The binding sites of Fluorine atom in the Structure of M1-Star-T4L in Complex with GSK1034702 at 2.5A (pdb code 6zg9). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Structure of M1-Star-T4L in Complex with GSK1034702 at 2.5A, PDB code: 6zg9:

Fluorine binding site 1 out of 1 in 6zg9

Go back to Fluorine Binding Sites List in 6zg9
Fluorine binding site 1 out of 1 in the Structure of M1-Star-T4L in Complex with GSK1034702 at 2.5A


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Structure of M1-Star-T4L in Complex with GSK1034702 at 2.5A within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F1201

b:25.8
occ:1.00
F1 A:QK21201 0.0 25.8 1.0
C5 A:QK21201 1.3 24.1 1.0
C4 A:QK21201 2.4 22.3 1.0
C6 A:QK21201 2.4 23.6 1.0
N1 A:QK21201 3.1 21.7 1.0
CB A:CYS178 3.4 34.5 1.0
CE3 A:TRP91 3.4 38.2 1.0
CZ3 A:TRP91 3.4 39.9 1.0
CD2 A:TYR85 3.5 30.0 1.0
CG A:TYR85 3.5 29.7 1.0
SG A:CYS178 3.6 39.1 1.0
C3 A:QK21201 3.6 16.2 1.0
C1 A:QK21201 3.7 23.7 1.0
O A:CYS178 3.9 34.2 1.0
CE2 A:TYR85 3.9 30.2 1.0
CB A:TYR85 3.9 29.1 1.0
CD1 A:TYR85 4.1 31.5 1.0
C2 A:QK21201 4.2 19.0 1.0
CD2 A:TRP91 4.3 37.1 1.0
CH2 A:TRP91 4.3 40.7 1.0
C7 A:QK21201 4.4 22.7 1.0
CZ A:TYR85 4.4 35.5 1.0
C A:CYS178 4.5 33.6 1.0
CA A:CYS178 4.5 33.3 1.0
CE1 A:TYR85 4.5 31.6 1.0
N2 A:QK21201 4.7 25.2 1.0
CD1 A:TYR82 4.8 32.5 1.0
C18 A:QK21201 4.9 9.8 1.0

Reference:

P.Rucktooa, R.M.Cooke. From Structure to Clinic: the Discovery of Selective M1 Muscarinic Acetylcholine Receptor Agonist For the Treatment of Memory Loss in Alzheimer'S Disease To Be Published.
Page generated: Fri Aug 2 05:12:48 2024

Last articles

Zn in 9JYW
Zn in 9IR4
Zn in 9IR3
Zn in 9GMX
Zn in 9GMW
Zn in 9JEJ
Zn in 9ERF
Zn in 9ERE
Zn in 9EGV
Zn in 9EGW
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy