Fluorine »
PDB 6zqs-7adg »
6zxi »
Fluorine in PDB 6zxi: Crystal Structure of the Oxa-48 Carbapenem-Hydrolyzing Class D Beta- Lactamase in Complex with the Dbo Inhibitor ANT3310
Enzymatic activity of Crystal Structure of the Oxa-48 Carbapenem-Hydrolyzing Class D Beta- Lactamase in Complex with the Dbo Inhibitor ANT3310
All present enzymatic activity of Crystal Structure of the Oxa-48 Carbapenem-Hydrolyzing Class D Beta- Lactamase in Complex with the Dbo Inhibitor ANT3310:
3.5.2.6;
3.5.2.6;
Protein crystallography data
The structure of Crystal Structure of the Oxa-48 Carbapenem-Hydrolyzing Class D Beta- Lactamase in Complex with the Dbo Inhibitor ANT3310, PDB code: 6zxi
was solved by
J.D.Docquier,
C.Pozzi,
F.De Luca,
M.Benvenuti,
S.Mangani,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 52.61 / 1.85 |
| Space group | P 2 21 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 44.798, 105.106, 125.426, 90, 90, 90 |
| R / Rfree (%) | 17.2 / 21.8 |
Other elements in 6zxi:
The structure of Crystal Structure of the Oxa-48 Carbapenem-Hydrolyzing Class D Beta- Lactamase in Complex with the Dbo Inhibitor ANT3310 also contains other interesting chemical elements:
| Chlorine | (Cl) | 1 atom |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of the Oxa-48 Carbapenem-Hydrolyzing Class D Beta- Lactamase in Complex with the Dbo Inhibitor ANT3310
(pdb code 6zxi). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Crystal Structure of the Oxa-48 Carbapenem-Hydrolyzing Class D Beta- Lactamase in Complex with the Dbo Inhibitor ANT3310, PDB code: 6zxi:
Jump to Fluorine binding site number: 1; 2;
In total 2 binding sites of Fluorine where determined in the Crystal Structure of the Oxa-48 Carbapenem-Hydrolyzing Class D Beta- Lactamase in Complex with the Dbo Inhibitor ANT3310, PDB code: 6zxi:
Jump to Fluorine binding site number: 1; 2;
Fluorine binding site 1 out of 2 in 6zxi
Go back to
Fluorine Binding Sites List in 6zxi
Fluorine binding site 1 out
of 2 in the Crystal Structure of the Oxa-48 Carbapenem-Hydrolyzing Class D Beta- Lactamase in Complex with the Dbo Inhibitor ANT3310
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Crystal Structure of the Oxa-48 Carbapenem-Hydrolyzing Class D Beta- Lactamase in Complex with the Dbo Inhibitor ANT3310 within 5.0Å range:
|
Fluorine binding site 2 out of 2 in 6zxi
Go back to
Fluorine Binding Sites List in 6zxi
Fluorine binding site 2 out
of 2 in the Crystal Structure of the Oxa-48 Carbapenem-Hydrolyzing Class D Beta- Lactamase in Complex with the Dbo Inhibitor ANT3310
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Crystal Structure of the Oxa-48 Carbapenem-Hydrolyzing Class D Beta- Lactamase in Complex with the Dbo Inhibitor ANT3310 within 5.0Å range:
|
Reference:
D.T.Davies,
S.Leiris,
N.Sprynski,
J.Castandet,
C.Lozano,
J.Bousquet,
M.Zalacain,
F.Marcoccia,
M.Benvenuti,
C.Pozzi,
S.Mangani,
J.D.Docquier,
M.Lemonnier,
M.Everett.
Discovery of Sodium (2R,5R)-2-Fluoro-7-Oxo-1,6-Diazabicyclo[3.2.1]Octan-6-Yl Sulphate (ANT3310), A Novel Broad-Spectrum Serine Beta-Lactamase Inhibitor of the Diazabicyclooctane Class, Differentiated By Additional Activity in Combination with Meropenem Against the Who Priority Pathogens Carbapenem Resistant Acinetobacter Baumannii (Crab) To Be Published.
Page generated: Fri Aug 2 05:27:09 2024
Last articles
Zn in 9JPJZn in 9JP7
Zn in 9JPK
Zn in 9JPL
Zn in 9GN6
Zn in 9GN7
Zn in 9GKU
Zn in 9GKW
Zn in 9GKX
Zn in 9GL0
