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Atomistry » Fluorine » PDB 6zqs-7adg » 7a16 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 6zqs-7adg » 7a16 » |
Fluorine in PDB 7a16: Crystal Structure of Human Methionine Aminopeptidase-2 in Complex with An Inhibitor GSK2229238A (Compound 43)Enzymatic activity of Crystal Structure of Human Methionine Aminopeptidase-2 in Complex with An Inhibitor GSK2229238A (Compound 43)
All present enzymatic activity of Crystal Structure of Human Methionine Aminopeptidase-2 in Complex with An Inhibitor GSK2229238A (Compound 43):
3.4.11.18; Protein crystallography data
The structure of Crystal Structure of Human Methionine Aminopeptidase-2 in Complex with An Inhibitor GSK2229238A (Compound 43), PDB code: 7a16
was solved by
J.H.Thorpe,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 7a16:
The structure of Crystal Structure of Human Methionine Aminopeptidase-2 in Complex with An Inhibitor GSK2229238A (Compound 43) also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of Human Methionine Aminopeptidase-2 in Complex with An Inhibitor GSK2229238A (Compound 43)
(pdb code 7a16). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Crystal Structure of Human Methionine Aminopeptidase-2 in Complex with An Inhibitor GSK2229238A (Compound 43), PDB code: 7a16: Jump to Fluorine binding site number: 1; 2; Fluorine binding site 1 out of 2 in 7a16Go back to Fluorine Binding Sites List in 7a16
Fluorine binding site 1 out
of 2 in the Crystal Structure of Human Methionine Aminopeptidase-2 in Complex with An Inhibitor GSK2229238A (Compound 43)
Mono view Stereo pair view
Fluorine binding site 2 out of 2 in 7a16Go back to Fluorine Binding Sites List in 7a16
Fluorine binding site 2 out
of 2 in the Crystal Structure of Human Methionine Aminopeptidase-2 in Complex with An Inhibitor GSK2229238A (Compound 43)
Mono view Stereo pair view
Reference:
D.J.Hirst,
M.Brandt,
G.Bruton,
E.Christodoulou,
L.Cutler,
N.Deeks,
J.D.Goodacre,
T.Jack,
M.Lindon,
A.Miah,
K.Page,
N.Parr,
L.Shukla,
M.Sims,
P.Thomas,
J.Thorpe,
D.S.Holmes.
Structure-Based Optimisation of Orally Active & Reversible Metap-2 Inhibitors Maintaining A Tight 'Molecular Budget'. Bioorg.Med.Chem.Lett. V. 30 27533 2020.
Page generated: Fri Aug 2 05:29:02 2024
ISSN: ESSN 1464-3405 PubMed: 32919012 DOI: 10.1016/J.BMCL.2020.127533 |
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