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Atomistry » Fluorine » PDB 6zqs-7adg » 7a5n | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 6zqs-7adg » 7a5n » |
Fluorine in PDB 7a5n: Structure of DYRK1A in Complex with Compound 34Enzymatic activity of Structure of DYRK1A in Complex with Compound 34
All present enzymatic activity of Structure of DYRK1A in Complex with Compound 34:
2.7.12.1; Protein crystallography data
The structure of Structure of DYRK1A in Complex with Compound 34, PDB code: 7a5n
was solved by
P.Dokurno,
A.E.Surgenor,
R.E.Hubbard,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 7a5n:
The structure of Structure of DYRK1A in Complex with Compound 34 also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Structure of DYRK1A in Complex with Compound 34
(pdb code 7a5n). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 4 binding sites of Fluorine where determined in the Structure of DYRK1A in Complex with Compound 34, PDB code: 7a5n: Jump to Fluorine binding site number: 1; 2; 3; 4; Fluorine binding site 1 out of 4 in 7a5nGo back to Fluorine Binding Sites List in 7a5n
Fluorine binding site 1 out
of 4 in the Structure of DYRK1A in Complex with Compound 34
Mono view Stereo pair view
Fluorine binding site 2 out of 4 in 7a5nGo back to Fluorine Binding Sites List in 7a5n
Fluorine binding site 2 out
of 4 in the Structure of DYRK1A in Complex with Compound 34
Mono view Stereo pair view
Fluorine binding site 3 out of 4 in 7a5nGo back to Fluorine Binding Sites List in 7a5n
Fluorine binding site 3 out
of 4 in the Structure of DYRK1A in Complex with Compound 34
Mono view Stereo pair view
Fluorine binding site 4 out of 4 in 7a5nGo back to Fluorine Binding Sites List in 7a5n
Fluorine binding site 4 out
of 4 in the Structure of DYRK1A in Complex with Compound 34
Mono view Stereo pair view
Reference:
D.Lee Walmsley,
J.B.Murray,
P.Dokurno,
A.J.Massey,
K.Benwell,
A.Fiumana,
N.Foloppe,
S.Ray,
J.Smith,
A.E.Surgenor,
T.Edmonds,
D.Demarles,
M.Burbridge,
F.Cruzalegui,
A.Kotschy,
R.E.Hubbard.
Fragment-Derived Selective Inhibitors of Dual-Specificity Kinases DYRK1A and DYRK1B. J.Med.Chem. 2021.
Page generated: Fri Aug 2 05:30:12 2024
ISSN: ISSN 0022-2623 PubMed: 34143631 DOI: 10.1021/ACS.JMEDCHEM.1C00024 |
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