Fluorine in PDB 7a8p: Structure of Human Mitochondrial Rna Polymerase in Complex with Imt Inhibitor.

All present enzymatic activity of Structure of Human Mitochondrial Rna Polymerase in Complex with Imt Inhibitor.:
2.7.7.6;

The structure of Structure of Human Mitochondrial Rna Polymerase in Complex with Imt Inhibitor. also contains other interesting chemical elements:

Chlorine

(Cl)

1 atom

The binding sites of Fluorine atom in the Structure of Human Mitochondrial Rna Polymerase in Complex with Imt Inhibitor. (pdb code 7a8p). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Structure of Human Mitochondrial Rna Polymerase in Complex with Imt Inhibitor., PDB code: 7a8p:

Fluorine binding site 1 out of 1 in the Structure of Human Mitochondrial Rna Polymerase in Complex with Imt Inhibitor.


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Structure of Human Mitochondrial Rna Polymerase in Complex with Imt Inhibitor. within 5.0Å range: probe atom residue distance (Å) B Occ A:F1301 b:27.6 occ:1.00 F13 A:R4Q1301 0.0 27.6 1.0 C12 A:R4Q1301 1.3 27.6 1.0 C14 A:R4Q1301 2.3 27.6 1.0 C11 A:R4Q1301 2.3 27.6 1.0 CG2 A:VAL709 3.1 26.2 1.0 CD1 A:LEU789 3.3 27.9 1.0 CA A:ALA786 3.4 29.4 1.0 C15 A:R4Q1301 3.6 27.6 1.0 C10 A:R4Q1301 3.6 27.6 1.0 CB A:ALA786 3.9 29.4 1.0 CB A:LEU789 3.9 27.9 1.0 N A:ALA786 4.0 29.4 1.0 O A:LEU785 4.0 30.3 1.0 CZ A:PHE794 4.1 19.6 1.0 C09 A:R4Q1301 4.1 27.6 1.0 CZ A:PHE813 4.1 25.8 1.0 CG A:LEU789 4.2 27.9 1.0 C A:LEU785 4.2 30.3 1.0 CE1 A:PHE794 4.3 19.6 1.0 C A:ALA786 4.5 29.4 1.0 O A:ALA786 4.5 29.4 1.0 CB A:VAL709 4.6 26.2 1.0 CE2 A:PHE813 4.7 25.8 1.0 CE2 A:PHE794 4.7 19.6 1.0 CD2 A:LEU825 4.8 23.6 1.0

N.A.Bonekamp, B.Peter, H.S.Hillen, A.Felser, T.Bergbrede, A.Choidas, M.Horn, A.Unger, R.Di Lucrezia, I.Atanassov, X.Li, U.Koch, S.Menninger, J.Boros, P.Habenberger, P.Giavalisco, P.Cramer, M.S.Denzel, P.Nussbaumer, B.Klebl, M.Falkenberg, C.M.Gustafsson, N.G.Larsson. Small-Molecule Inhibitors of Human Mitochondrial Dna Transcription. Nature V. 588 712 2020.
ISSN: ESSN 1476-4687
PubMed: 33328633
DOI: 10.1038/S41586-020-03048-Z