Fluorine in PDB 7aap: NSP7-NSP8-NSP12 Sars-COV2 Rna-Dependent Rna Polymerase in Complex with Template:Primer Dsrna and Favipiravir-Rtp

Enzymatic activity of NSP7-NSP8-NSP12 Sars-COV2 Rna-Dependent Rna Polymerase in Complex with Template:Primer Dsrna and Favipiravir-Rtp

All present enzymatic activity of NSP7-NSP8-NSP12 Sars-COV2 Rna-Dependent Rna Polymerase in Complex with Template:Primer Dsrna and Favipiravir-Rtp:
2.7.7.48; 3.4.19.12; 3.4.22.69; 3.6.4.12; 3.6.4.13;

Other elements in 7aap:

The structure of NSP7-NSP8-NSP12 Sars-COV2 Rna-Dependent Rna Polymerase in Complex with Template:Primer Dsrna and Favipiravir-Rtp also contains other interesting chemical elements:

Magnesium (Mg) 3 atoms
Zinc (Zn) 2 atoms

Fluorine Binding Sites:

The binding sites of Fluorine atom in the NSP7-NSP8-NSP12 Sars-COV2 Rna-Dependent Rna Polymerase in Complex with Template:Primer Dsrna and Favipiravir-Rtp (pdb code 7aap). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the NSP7-NSP8-NSP12 Sars-COV2 Rna-Dependent Rna Polymerase in Complex with Template:Primer Dsrna and Favipiravir-Rtp, PDB code: 7aap:

Fluorine binding site 1 out of 1 in 7aap

Go back to Fluorine Binding Sites List in 7aap
Fluorine binding site 1 out of 1 in the NSP7-NSP8-NSP12 Sars-COV2 Rna-Dependent Rna Polymerase in Complex with Template:Primer Dsrna and Favipiravir-Rtp


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of NSP7-NSP8-NSP12 Sars-COV2 Rna-Dependent Rna Polymerase in Complex with Template:Primer Dsrna and Favipiravir-Rtp within 5.0Å range:
probe atom residue distance (Å) B Occ
T:F1601

b:79.7
occ:1.00
 F01 T:GE61601 0.0 79.7 1.0
C07 T:GE61601 1.3 79.7 1.0
N03 T:GE61601 2.3 79.7 1.0
C06 T:GE61601 2.4 79.7 1.0
C08 T:GE61601 3.5 79.7 1.0
C5 P:U20 3.5 14.0 1.0
N02 T:GE61601 3.6 79.7 1.0
C4 P:U20 3.6 14.0 1.0
O07 T:GE61601 3.7 79.7 1.0
NZ A:LYS545 3.7 85.2 1.0
C6 P:U20 3.8 14.0 1.0
N3 P:U20 3.9 14.0 1.0
O4 P:U20 4.0 14.0 1.0
C10 T:GE61601 4.1 79.7 1.0
O06 T:GE61601 4.1 79.7 1.0
N1 P:U20 4.1 14.0 1.0
O13 T:GE61601 4.2 79.7 1.0
C2 P:U20 4.2 14.0 1.0
P01 T:GE61601 4.5 79.7 1.0
P02 T:GE61601 4.5 79.7 1.0
C09 T:GE61601 4.7 79.7 1.0
O08 T:GE61601 4.7 79.7 1.0
C2' P:U20 4.7 14.0 1.0
O04 T:GE61601 4.8 79.7 1.0
C03 T:GE61601 4.9 79.7 1.0
O01 T:GE61601 4.9 79.7 1.0

Reference:

K.Naydenova, K.W.Muir, L.F.Wu, Z.Zhang, F.Coscia, M.Peet, P.Castro-Hartman, P.Qian, K.Sader, K.Dent, D.Kimanius, J.D.Sutherland, J.Loewe, D.Barford, C.J.Russo. NSP7-NSP8-NSP12 Sars-COV2 Rna-Dependent Rna Polymerase in Complex with Template:Primer Dsrna and Favipiravir-Rtp To Be Published.
Page generated: Sun Dec 13 13:47:53 2020

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