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Fluorine in PDB 7aw0: Mertk Kinase Domain in Complex with Purine InhibitorEnzymatic activity of Mertk Kinase Domain in Complex with Purine Inhibitor
All present enzymatic activity of Mertk Kinase Domain in Complex with Purine Inhibitor:
2.7.10.1; Protein crystallography data
The structure of Mertk Kinase Domain in Complex with Purine Inhibitor, PDB code: 7aw0
was solved by
M.Schimpl,
J.W.M.Nissink,
C.Blackett,
M.Clarke,
J.Disch,
K.Goldberg,
J.Guilinger,
E.J.Hennessy,
R.Jetson,
D.Ginkunja,
E.Hardaker,
A.Keefe,
W.Mccoull,
L.Mcmurray,
O.Collingwood,
R.Overman,
A.Pflug,
M.Preston,
P.Rawlins,
E.Rivers,
P.Smith,
E.Underwood,
C.Truman,
J.Warwicker,
J.Winter,
S.Woodcock,
Y.Zhang,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Mertk Kinase Domain in Complex with Purine Inhibitor
(pdb code 7aw0). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Mertk Kinase Domain in Complex with Purine Inhibitor, PDB code: 7aw0: Jump to Fluorine binding site number: 1; 2; Fluorine binding site 1 out of 2 in 7aw0Go back to Fluorine Binding Sites List in 7aw0
Fluorine binding site 1 out
of 2 in the Mertk Kinase Domain in Complex with Purine Inhibitor
Mono view Stereo pair view
Fluorine binding site 2 out of 2 in 7aw0Go back to Fluorine Binding Sites List in 7aw0
Fluorine binding site 2 out
of 2 in the Mertk Kinase Domain in Complex with Purine Inhibitor
Mono view Stereo pair view
Reference:
J.W.M.Nissink,
C.Blackett,
M.Clarke,
J.Disch,
K.Goldberg,
J.Guilinger,
E.J.Hennessy,
R.Jetson,
D.Ginkunja,
E.Hardaker,
A.Keefe,
W.Mccoull,
L.Mcmurray,
O.Collingwood,
R.Overman,
A.Pflug,
M.Preston,
P.Rawlins,
E.Rivers,
M.Schimpl,
P.Smith,
E.Underwood,
C.Truman,
J.Warwicker,
J.Winter,
S.Woodcock,
Y.Zhang.
Generating Selective Leads For Mer Kinase Inhibitors - Example of A Comprehensive Lead-Generation Strategy J.Med.Chem. 2021.
Page generated: Sat Apr 3 15:06:39 2021
ISSN: ISSN 0022-2623 |
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