Fluorine in PDB 7axq: Structure of the Cryo-Trapped WDR5:Cs-VIP8 Cocrystal After Illumination at 405 Nm and 180 K

The structure of Structure of the Cryo-Trapped WDR5:Cs-VIP8 Cocrystal After Illumination at 405 Nm and 180 K, PDB code: 7axq was solved by L.Werel, L.-O.Essen, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	44.55 / 1.56
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	47, 47.25, 133.62, 90, 90, 90
R / Rfree (%)	16.7 / 20

The binding sites of Fluorine atom in the Structure of the Cryo-Trapped WDR5:Cs-VIP8 Cocrystal After Illumination at 405 Nm and 180 K (pdb code 7axq). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 4 binding sites of Fluorine where determined in the Structure of the Cryo-Trapped WDR5:Cs-VIP8 Cocrystal After Illumination at 405 Nm and 180 K, PDB code: 7axq:
Jump to Fluorine binding site number: 1; 2; 3; 4;

Fluorine binding site 1 out of 4 in the Structure of the Cryo-Trapped WDR5:Cs-VIP8 Cocrystal After Illumination at 405 Nm and 180 K


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Structure of the Cryo-Trapped WDR5:Cs-VIP8 Cocrystal After Illumination at 405 Nm and 180 K within 5.0Å range: probe atom residue distance (Å) B Occ B:F7 b:32.6 occ:0.84 FA2 B:S7Z7 0.0 32.6 0.8 CA2 B:S7Z7 1.4 28.5 0.9 CA3 B:S7Z7 2.3 28.0 1.0 CA1 B:S7Z7 2.4 33.3 1.0 NA1 B:S7Z7 3.0 34.7 0.6 CA4 B:S7Z7 3.6 21.7 0.9 CA6 B:S7Z7 3.6 31.0 0.8 FB2 B:S7Z7 4.0 33.9 0.9 CA5 B:S7Z7 4.1 24.4 0.9 NB1 B:S7Z7 4.3 32.1 0.8 O B:HOH106 4.7 27.9 1.0 FA6 B:S7Z7 4.8 30.9 0.6 CA B:S7Z7 4.8 24.4 1.0 CB2 B:S7Z7 4.9 28.6 0.9

Fluorine binding site 2 out of 4 in the Structure of the Cryo-Trapped WDR5:Cs-VIP8 Cocrystal After Illumination at 405 Nm and 180 K


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Structure of the Cryo-Trapped WDR5:Cs-VIP8 Cocrystal After Illumination at 405 Nm and 180 K within 5.0Å range: probe atom residue distance (Å) B Occ B:F7 b:30.9 occ:0.57 FA6 B:S7Z7 0.0 30.9 0.6 CA6 B:S7Z7 1.4 31.0 0.8 CA1 B:S7Z7 2.4 33.3 1.0 CA5 B:S7Z7 2.4 24.4 0.9 NA1 B:S7Z7 2.7 34.7 0.6 NB1 B:S7Z7 3.0 32.1 0.8 CB1 B:S7Z7 3.0 27.4 1.0 CB6 B:S7Z7 3.1 29.4 1.0 FB6 B:S7Z7 3.1 30.7 0.6 CE1 B:DPN5 3.4 28.2 0.9 CD1 B:DPN5 3.6 25.9 1.0 CA2 B:S7Z7 3.6 28.5 0.9 CA4 B:S7Z7 3.6 21.7 0.9 CB2 B:S7Z7 3.8 28.6 0.9 CB5 B:S7Z7 4.0 28.8 1.0 CA3 B:S7Z7 4.1 28.0 1.0 CZ B:DPN5 4.2 21.9 0.8 CG B:DPN5 4.4 24.5 0.9 FB2 B:S7Z7 4.4 33.9 0.9 CB3 B:S7Z7 4.6 27.1 1.0 CB4 B:S7Z7 4.6 25.9 1.0 FA2 B:S7Z7 4.8 32.6 0.8 CA B:S7Z7 4.9 24.4 1.0 CE2 B:DPN5 5.0 19.7 0.9

Fluorine binding site 3 out of 4 in the Structure of the Cryo-Trapped WDR5:Cs-VIP8 Cocrystal After Illumination at 405 Nm and 180 K


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Structure of the Cryo-Trapped WDR5:Cs-VIP8 Cocrystal After Illumination at 405 Nm and 180 K within 5.0Å range: probe atom residue distance (Å) B Occ B:F7 b:33.9 occ:0.89 FB2 B:S7Z7 0.0 33.9 0.9 CB2 B:S7Z7 1.3 28.6 0.9 CB1 B:S7Z7 2.3 27.4 1.0 CB3 B:S7Z7 2.4 27.1 1.0 NB1 B:S7Z7 2.7 32.1 0.8 NA1 B:S7Z7 3.2 34.7 0.6 CA1 B:S7Z7 3.4 33.3 1.0 CB6 B:S7Z7 3.6 29.4 1.0 CB4 B:S7Z7 3.6 25.9 1.0 CA2 B:S7Z7 3.9 28.5 0.9 FA2 B:S7Z7 4.0 32.6 0.8 O B:HOH108 4.1 33.6 1.0 CA6 B:S7Z7 4.1 31.0 0.8 CB5 B:S7Z7 4.1 28.8 1.0 FA6 B:S7Z7 4.4 30.9 0.6 FB6 B:S7Z7 4.7 30.7 0.6 CA3 B:S7Z7 4.7 28.0 1.0 CB B:S7Z7 4.9 30.2 1.0 CA5 B:S7Z7 4.9 24.4 0.9

Fluorine binding site 4 out of 4 in the Structure of the Cryo-Trapped WDR5:Cs-VIP8 Cocrystal After Illumination at 405 Nm and 180 K


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of Structure of the Cryo-Trapped WDR5:Cs-VIP8 Cocrystal After Illumination at 405 Nm and 180 K within 5.0Å range: probe atom residue distance (Å) B Occ B:F7 b:30.7 occ:0.58 FB6 B:S7Z7 0.0 30.7 0.6 CB6 B:S7Z7 1.3 29.4 1.0 CB5 B:S7Z7 2.3 28.8 1.0 CB1 B:S7Z7 2.4 27.4 1.0 NB1 B:S7Z7 3.0 32.1 0.8 FA6 B:S7Z7 3.1 30.9 0.6 CB4 B:S7Z7 3.6 25.9 1.0 CB2 B:S7Z7 3.6 28.6 0.9 NA1 B:S7Z7 4.1 34.7 0.6 CB3 B:S7Z7 4.1 27.1 1.0 CA6 B:S7Z7 4.3 31.0 0.8 CE1 B:DPN5 4.6 28.2 0.9 FB2 B:S7Z7 4.7 33.9 0.9 CA1 B:S7Z7 4.7 33.3 1.0 CD1 B:DPN5 4.8 25.9 1.0 CB B:S7Z7 4.8 30.2 1.0 OB B:S7Z7 5.0 32.7 0.9

L.Albert, J.Nagpal, W.Steinchen, L.Zhang, L.Werel, N.Djokovic, D.Ruzic, M.Hoffarth, J.Xu, J.Kaspareit, F.Abendroth, A.Royant, G.Bange, K.Nikolic, S.Ryu, Y.Dou, L.-O.Essen, O.Vazquez. Bistable Photoswitch Allows in Vivo Control of Hematopoiesis To Be Published.